Delicate magnolia-jasmine scent activates human pheromone receptor

Hedione activates pheromone receptor in olfactory epithelium

Using genetic-analysis approaches, the researchers from Bochum confirmed the pheromone receptor's existence in human olfactory mucosa. Subsequently, they transferred the genetic code for the receptor into cell cultures and, using these cells, demonstrated that Hedione activates the receptor. Hedione -- derived from the Greek word "hedone," for fun, pleasure, lust -- has a pleasant fresh jasmine-magnolia scent and is utilized in many perfumes. It is also called the scent of success.

Sex-specific brain activation may be related to the release of sex hormones

Together with the team headed by Prof Dr med Thomas Hummel from the University Hospital Dresden, the group from Bochum analysed what happens in the brain when a person smells Hedione. They compared the results with the effects triggered by phenylethyl alcohol, a traditional floral fragrance. Hedione activated brain areas in the limbic system significantly more strongly than phenylethyl alcohol. The limbic system is associated with emotions, memory and motivation. In addition, Hedione activated a specific hypothalamic region, in women more strongly than in men. This activation pattern is typical for controlling sexual behaviour via the endocrine system.

Next steps are in progress

"In the next stage, we want to find out which physiological and psychological parameters are affected when Hedione activates the pheromone receptor," explains Hanns Hatt. "We have already launched the relevant studies. But we also have to search for scent molecules in bodily secretions, which resemble Hedione and activate the receptor. With its help, humans could actually communicate with each other."

Pheromone receptors in humans and animals

Pheromones are substances that facilitate chemical communication between members of the same species. They trigger a homogenous, repeatable reaction. In the animal kingdom, this kind of communication is very widespread. Mice have approx. 300 different genes for pheromone receptors; in humans, probably only five of them are still functional. Most mammals have a special organ located at the base of the nasal septum, i.e. the vomeronasal organ. According to contemporary research this organ fulfills no function in humans anymore. However, researchers at RUB and other institutes have demonstrated in the recent years that pheromone receptors may also occur in the olfactory epithelium in humans and in mice.