Loss of key estrogen regulator may lead to metabolic syndrome and atherosclerosis

This early preclinical study in female mice demonstrated that removing estrogen regulator alpha alone was enough to reduce the immune system's protective process and promote increased fat accumulation and accelerate atherosclerosis development. Without this protein, the mice developed additional aspects of metabolic syndrome such as glucose intolerance, insulin resistance and inflammation.

This estrogen receptor is also expressed in many other non-reproductive tissues such as fat, muscle and liver and can also act independent of the hormone estrogen. However, little is known about the receptor's actions in these tissues that are involved in blood-sugar regulation, which plays an integral role in metabolic syndrome.

Researchers hope that these early findings may provide insight into the development of metabolic syndrome, which affects millions of people worldwide. A better understanding of the activity of this receptor may lead to improved future therapies.

"Impairment of this receptor's function could also play a role in the heightened incidence of metabolic syndrome being seen in younger women," said senior author Andrea Hevener, Ph.D., associate professor of endocrinology, diabetes and hypertension, David Geffen School of Medicine at UCLA. "We may find that action of this estrogen receptor is just as important as that of circulating estrogen, which is key in multiple therapies such as HRT."

Hevener notes that her team will next study the status of this estrogen receptor in pre and postmenopausal women.

The research was funded by the National Institutes of Health -- NIDDK, the Iris Cantor-UCLA Women's Health Foundation, and the UCLA Department of Medicine.

The study will appear in the early edition of the Proceedings of the National Academy of Sciences (PNAS) during the week of Sept. 5.