Personalized adhesives for inner healing -- now tailored just for you

Professor Hyung Joon Cha from the Department of Chemical Engineering and the School of Convergence Science and Technology at Pohang University of Science and Technology (POSTECH), along with PhD candidate Jang Woo Yang (Department of Chemical Engineering, POSTECH), senior researcher Hwa Hui Shin from the Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDI Hub), and Professor Kang-Il Song from the Division of Smart Healthcare at Pukyong National University (PKNU), have garnered attention by using mussel-derived adhesive proteins to develop customized underwater bio-adhesive patches (CUBAP). This research will be featured as a frontispiece in the upcoming issue of Advanced Materials and has secured both domestic and international patents.

These patches are crucial in effectively sealing internal wounds, leaks, and perforations in the body's organs, aiding in healing and tissue regeneration. As research in internal transplant devices expands, there is a growing need for adhesives that can securely hold these devices in place. The biomedical adhesives used in such applications need to maintain strong adhesion underwater while minimizing side effects. The ability to customize features like biodegradation time is also essential, considering the unique biological environments of different organs.

Professor Hyung Joon Cha's research team members, pioneers in applying mussel adhesive proteins for medical adhesives, have taken a step further with the development of CUBAP. This adhesive is not only excellent in underwater adhesion but is also made from natural materials, ensuring safety and biocompatibility within the human body. The team has produced customized patches (CUBAP) by combining mussel adhesive protein with polyacrylic acid and polymethacrylic acid, and these are currently undergoing clinical evaluation for minimizing scarring in skin closures.

In its dry state, the patch is non-adhesive, but in the human body or other humid environments, it exhibits strong adhesive properties. Furthermore, researchers can control the degradation time and mechanical hardness by adjusting the polyacrylic acid and polymethacrylic acid ratios. This enables a customized adhesive system, considering the diverse structural and biological needs of different organs.

The research team created three types of customized adhesive patches and applied them in animal treatments and implants. These patches maintained high adhesion even in highly mobile organs such as the heart and bladder. They also conducted successful experiments in adjusting biodegradation times and flexibility during the transplantation of muscle regeneration electronic devices.

Professor Cha, the lead researcher, emphasized, "This research paves the way for personalized medical applications. We plan to enhance and refine the process through subsequent studies, with the goal of effective applications in diverse biomedical fields." Senior Researcher Hwa Hui Shin from K-MEDI Hub shared, "Our study has confirmed the effectiveness and versatility of the developed bio-adhesive patches. We look forward to their evolving into commercial products, meeting the demands of the healthcare sector."

This research was supported by the Mid-Career Research Program, the Young Research Program, and the Nano Material Technology Development Program through the National Research Foundation of Korea.