Molecular imaging offers insight into chemo-brain

CRCI describes a clinical condition characterized by memory and concentration impairment, difficulties with information processing and executive functioning, and mood and anxiety disorders. While CRCI has been widely investigated from a clinical perspective, little is known about the underlying biological mechanisms that cause chemo-brain.

"Nuclear medicine techniques can be used to investigate different physiopathological phenomena related to CRCI, such as cortical metabolism, dopamine transporter integrity, and neuroinflammation, with specific imaging probes," said Agostino Chiaravalloti, MD, PhD, professor of nuclear medicine and nuclear medicine physician in the Department of Biomedicine and Prevention at University Tor Vergata in Rome, Italy. "However, nuclear medicine tests are not commonly considered in the work-up of patients with CRCI-related manifestations."

To understand the current landscape of nuclear medicine and molecular imaging for chemo-brain, researchers undertook an extensive literature review. Following the PRISMA guidelines for literature searches, the researchers identified 22 relevant studies on two topics: 1) the effects of the most commonly used chemotherapy drugs on cognitive function and 2) the results of SPECT and PET examinations of CRCI. The findings confirmed the impact of chemotherapy drugs on cognitive function, such as impaired executive function, anxiety and trouble sleeping. They also highlighted the utility of various SPECT and PET imaging techniques to visualize glucose consumption, blood flow, or expression of receptors, all of which may play a role in CRCI.

In this context, nuclear medicine offers several instruments for the detailed evaluation of the physiopathological processes that underlie CRCI. "The findings presented could lead to a better understanding of the potential role of molecular imaging in the assessment of subtle changes in the brain after treatment and, possibly, in the monitoring of brain functions in patients treated with chemotherapy," stated Chiaravalloti.

This study was made available online in February 2023.