Camels to help fight Alzheimer's? New class of antibody from camelids that can cross the blood-brain barrier

"This basic biological investigation opens new pathways toward innovative therapeutic solutions for intractable diseases such as Alzheimer's disease or brain tumors," said Pierre Lafaye, Ph.D., a researcher involved in the work from the Institut Pasteur, PF: Production de Protéines Recombinantes et d'Anticorps -Proteopole in Paris, France. "The importance of this study is the hope that this novel approach may be a useful tool in crossing the blood brain barrier for diagnostic and therapeutic purposes," added Babbette Weksler, MD, Professor of Medicine, Weill Cornell Medical College, New York, NY, another author of the study and editorial board member of The FASEB Journal.

Lafaye and colleagues studied alpacas, a member of the camelid family, and discovered an antibody naturally able to cross the blood brain barrier without chemical modification. Then, additional research showed that after these antibodies entered the brain successfully, they diffused into the brain tissue to reach a target, which in this study was astrocytes. This study shows, for the first time, an antibody penetrated into the brain in vivo, under normal physiological conditions. In addition to the obvious clinical applications of this finding, it opens the doors to new research involving the body's systems for recognizing self v. "nonself."

"Camels may be most famous for helping people travel to the outermost reaches of the desert, but soon they could be also known for helping us reach the innermost parts of our brains," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "It appears that these prized animals are far more capable of helping get to hard-to-reach places than we ever could have imagined."