Cerebrospinal fluid test can pick up Alzheimer's before symptoms appear

In Alzheimer's disease, a protein fragment called beta-amyloid forms clumps between the nerve cells of the brain, causing the disease's characteristic effects on memory and function. The nerve fibres also become tangled, causing certain proteins to be released into the cerebrospinal fluid (CSF).

Led by Kaj Blennow, one of the world's leading Alzheimer's experts, researchers at the University of Gothenburg's Sahlgrenska Academy have developed a way of measuring these proteins and protein fragments in the CSF so that they can be used as biomarkers -- substances that reflect biological processes in the body and allow more reliable diagnoses in people with cognitive disorders.

Detect at early stage

"We found that levels of these proteins change in the CSF even with early symptoms, and we will probably be able to detect changes in the brain at a very early stage of the disease," says doctoral student Niklas Mattsson, whose thesis builds on the results.

To promote wider use of these new biomarkers, the researchers in Gothenburg have established an international quality control programme for these measurements. Besides facilitating diagnosis, the biomarkers could also be used when new drugs for Alzheimer's are tested.

Thesis.