Light exercise may prevent osteoarthritis, study suggests

"According to the results of our study, participating in a high-impact activity, such as running, more than one hour per day at least three times a week appears associated with more degenerated cartilage and potentially a higher risk for development of osteoarthritis," said the study's senior author Thomas M. Link, M.D., professor of radiology and chief of musculoskeletal imaging at the University of California, San Francisco (UCSF). "On the other hand, engaging in light exercise and refraining from frequent knee-bending activities may protect against the onset of the disease."

Osteoarthritis is a degenerative joint disease that causes pain, swelling and stiffness. According to the National Institute of Arthritis and Musculoskeletal and Skin Diseases, osteoarthritis is the most common form of arthritis and affects an estimated 27 million Americans over the age of 25.

For the study, the researchers recruited 132 asymptomatic participants at risk for knee osteoarthritis who were enrolled in the National Institutes of Health Osteoarthritis Initiative, as well as 33 age- and body mass index-matched controls. Study participants included 99 women and 66 men between the ages of 45 and 55. The participants were separated into three exercise and strength-training levels, based on their responses to the Physical Activity Scale for the Elderly (PASE) questionnaire. Exercise levels included sedentary, light exercisers and moderate to strenuous exercisers, strength-training groups included none, minimal and frequent. Knee-bending activities were also analyzed.

MRI exams revealed that light exercisers had the healthiest knee cartilage among all exercise levels, and patients with minimal strength training had healthier cartilage than patients with either no strength training or frequent strength training.

Moderate to strenuous exercise in women who did any amount of strength training was associated with higher water content and more degenerated collagen architecture in the knee.

"The results for this group indicate that moderate to strenuous exercise may accelerate cartilage degeneration, putting these women at even greater risk of developing osteoarthritis," said study coauthor Keegan K. Hovis, B.S., R.N., research associate in the Department of Radiology at UCSF.

In addition, the findings showed that frequent knee-bending activities, such as climbing up at least 10 flights of stairs a day, lifting objects weighing more than 25 pounds, or squatting, kneeling or deep knee bending for at least 30 minutes per day, were associated with higher water content and cartilage abnormalities.

According to Dr. Link, known risk factors for cartilage degeneration include excess weight, knee injuries, frequent knee bending and severe or strenuous physical activity.

"People can reduce their risk for osteoarthritis by maintaining a healthy weight and avoiding risky activities and strenuous exercise," he said. "Lower-impact sports, such as walking, swimming or using an elliptical trainer are likely more beneficial than high-impact sports, such as running or tennis."

"Our findings indicate that light exercise, particularly frequent walking, is a safer choice in maintaining healthy cartilage," Hovis added.

Other coauthors are Christoph Stehling, M.D., Jean-Baptiste Pialat, M.D., Michael C. Nevitt, Ph.D., M.P.H., and Charles E. McCulloch, Ph.D.