Greater obesity in offspring of nursing mothers consuming a high-fat diet

The researchers used a method called "cross-fostering" to determine whether prenatal or postnatal exposure to maternal high fat diet has a greater influence on the development of obesity and diabetes in the offspring. Rats were fed either a low fat or high fat diet during pregnancy. After birth, pups born to mothers that consumed either diet were fostered over to different mother rats that ate the same or opposite diet during the nursing period. The researchers found that rat pups nursed by mothers consuming a high fat diet gained more body weight and were obese when weaned a few weeks later, even if the pup's biological mother ate a low fat diet during pregnancy. In addition to being obese, pups nursed by foster mothers on a high fat diet displayed impaired glucose tolerance, an early indicator of diabetes.

According to lead author, Bo Sun, "These results suggest that high fat diet intake by nursing mothers may be more critical to the later development of obesity and diabetes in their offspring than high fat feeding during pregnancy. Therefore, to help prevent obesity and metabolic problems in their offspring, it may be most important for mothers to avoid consuming too much fat in their diet while nursing."

The lead author was Bo Sun of Dept. of Psychiatry & Behavioral Sciences, Johns Hopkins Univ., Baltimore, MD, USA

Co-Authors were R. Purcell, T. Moran and K. Tamashiro of  the Dept. of Psychiatry & Behavioral Sciences, Johns Hopkins Univ., Baltimore, MD, USA,  and J.Q. Yan of the Dept. of Physiology and Pathophysiology, Xi'an Jiaotong University School of Medicine, Xi'an, China.