New! Sign up for our free email newsletter.
Reference Terms
from Wikipedia, the free encyclopedia

Stress (medicine)

Stress is a medical term for a wide range of strong external stimuli, both physiological and psychological, which can cause a physiological response called the general adaptation syndrome. Historically, it was gradually realized that such concepts as anxiety, antagonism, exhaustion, frustration, distress, despair, overwork, pre-menstrual tension, over-focusing, confusion, mourning, and fear could all come together in a general broad term, stress.

The use of the term stress in serious and recognized cases, such as those of post-traumatic stress disorder and psychosomatic illness, has scarcely helped clear analysis of the generalized "stress" phenomenon. Nonetheless, some varieties of stress from negative life events (distress) and from positive life events (eustress) can clearly have a serious physical impact distinct from the troubles of what psychotherapists call the "worried well." Stress activates the sympathetic branch of the autonomous nervous system and the release of stress hormones including epinephrine, and cortisol.

Sympathetic nervous output produces the fight-or-flight response, causing the body to divert bloodflow to large muscles as the body prepares to run away from or fight something. Less blood flows to the digestive system and other organs that do not assist in fleeing or fighting, producing dry mouth, motor agitation, sweating, pallor, enlarged pupils and over the long term, insomnia. Modern stressors can cause continual sympathetic nervous system activation with very little opportunity for the parasympathetic nervous system to activate. When the parasympathetic system is active, the bowel and other non-muscle organs receive good blood-flow, the pupils constrict, and the glands all function well and secrete their various compounds.

Related Stories
 


Mind & Brain News

July 19, 2026

A low-cost antidepressant may offer new hope for people struggling with long COVID fatigue. In a randomized clinical trial involving 399 adults, fluvoxamine significantly reduced fatigue and improved quality of life compared with a placebo, making ...
Several popular sugar substitutes may not be as harmless as they seem. Adults who consumed the most artificial sweeteners showed substantially faster declines in memory and thinking, especially if they were under 60 or had diabetes. The highest ...
The Mediterranean diet may influence aging through tiny proteins produced inside the cell’s mitochondria. Older adults who followed the diet most closely had higher levels of humanin and SHMOOSE, ...
A drug originally developed for spinal cord injury may offer a fresh approach to treating Alzheimer’s disease. In mouse studies, KCL-286 repaired dangerous DNA damage, reduced inflammation, and targeted multiple disease-related pathways instead of ...
A new experimental treatment may have found a way to outsmart glioblastoma’s toughest defense: the blood-brain barrier. Researchers used sugar-coated nanoparticles to ferry genetic instructions ...
An existing constipation drug may have an unexpected new use: helping clear the "brain fog" that often lingers after depression. In a small clinical trial, people with a history of depression who took the medication prucalopride for about a week ...
Researchers have discovered that a microscopic skeleton inside neurons does much more than hold cells together. It acts as a gatekeeper that controls what brain cells absorb and when they absorb it. ...
Going to the cinema, visiting museums, or attending concerts may do more than entertain. Researchers found that older adults who regularly participated in cultural activities tended to have bodies that functioned like those of people about three ...
A new study suggests the brain begins making decisions much earlier than scientists previously thought. Researchers found that even primary sensory regions are influenced by higher brain areas through rapid feedback loops, rather than simply passing ...
Researchers analyzing data from more than 214,000 people found that dementia risk factors differ widely across countries, challenging the idea of a one-size-fits-all prevention strategy. At the same time, they uncovered surprisingly consistent ...
Researchers found that tau is essential for turning new experiences into lasting memories by helping organize the brain's memory-storing cells. The mouse study also revealed how abnormal tau may contribute to Alzheimer's by disrupting both the ...
Yale scientists discovered two neuron surface proteins that appear to help spread the toxic protein linked to Parkinson’s disease. Blocking these proteins in mice dramatically reduced disease ...

Latest Headlines

updated 12:56 pm ET