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May 10, 2023 Scientists have released a draft of the first human pangenome -- a new, usable reference for genomics that combines the genetic material of 47 individuals from different ancestral backgrounds to ...
Feb. 20, 2024 For many genetic diseases, disabling or editing a gene using CRISPR is insufficient to overcome the effects of the underlying genetic mutation. A corrective gene needs to be added to the genome to ...
Oct. 23, 2023 A team of researchers has developed a software tool that provides a way for the safer design of genome editing in all organisms with a transcriptome. For about a decade, researchers have used the ...
May 4, 2023 A major challenge in human genetics is understanding which parts of the genome drive specific traits or contribute to disease risk. This challenge is even greater for genetic variants found in the ...
Mar. 23, 2023 Damage in the human genome can be repaired. But this works better in germ cells, sperm and eggs, than in normal body cells. Responsible for this is the DREAM protein complex, which prevents the ...
Dec. 19, 2024 Mutational signatures etched into the cells' genome by an anti-cancer drug called temozolomide (TMZ) uncover an Achilles' heel for TMZ chemotherapy resistance, according to new ...
Oct. 22, 2024 A team of scientists has discovered surprising connections among gene activity, genome packing, and genome-wide motions, revealing aspects of the genome's organization that directly affect gene ...
Feb. 11, 2025 A new study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in eliciting damages to neurons that are most vulnerable in Huntington's disease and ...
Nov. 28, 2023 Researchers discovered a mechanism for repairing damaged nerves during peripheral neuropathy in mice, wherein the protein Mitf orchestrates nerve repair after both trauma-induced and chronic nerve ...
Dec. 4, 2024 CRISPR’s promise of curing diseases hit a setback when researchers discovered that AZD7648, a molecule designed to improve precision, also caused catastrophic hidden damage to DNA. Instead of ...