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Feb. 20, 2024 For many genetic diseases, disabling or editing a gene using CRISPR is insufficient to overcome the effects of the underlying genetic mutation. A corrective gene needs to be added to the genome to ...
Oct. 23, 2023 A team of researchers has developed a software tool that provides a way for the safer design of genome editing in all organisms with a transcriptome. For about a decade, researchers have used the ...
Dec. 19, 2024 Mutational signatures etched into the cells' genome by an anti-cancer drug called temozolomide (TMZ) uncover an Achilles' heel for TMZ chemotherapy resistance, according to new ...
Oct. 22, 2024 A team of scientists has discovered surprising connections among gene activity, genome packing, and genome-wide motions, revealing aspects of the genome's organization that directly affect gene ...
Feb. 11, 2025 A new study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in eliciting damages to neurons that are most vulnerable in Huntington's disease and ...
Nov. 28, 2023 Researchers discovered a mechanism for repairing damaged nerves during peripheral neuropathy in mice, wherein the protein Mitf orchestrates nerve repair after both trauma-induced and chronic nerve ...
Dec. 4, 2024 CRISPR’s promise of curing diseases hit a setback when researchers discovered that AZD7648, a molecule designed to improve precision, also caused catastrophic hidden damage to DNA. Instead of ...
Aug. 24, 2023 Researchers have uncovered a connection between the topography of the human genome and the presence of mutations in human cancer. Just as different terrains on Earth foster distinct ecosystems, ...
Apr. 14, 2025 Researchers have uncovered answers that provide the detail to explain two specific DNA repair processes that have long been in ...
June 13, 2024 Cancer genomes are the result of diverse mutation processes that have often accumulated over decades. Scientists have analyzed the molecular evolution of tumors after exposure to mutagenic chemicals. ...