Genome of aggressive lymphoma sequenced

The authors analyzed the genome of tumor cells at the onset of the disease and within several years after treatment, when the relapses occur. Thus, it has been possible to evaluate the genomic modifications associated with disease progression. These analyses have discovered the implication of several genes in the progression of these lymphomas and some mechanisms generating resistance to chemotherapy. They also defined a group of patients with very rapid progression of the disease with mutations in NOTCH1 and NOTCH2 genes. These mutations could become therapeutic targets because there are already drugs blocking the activity of these genes which may be useful in complicated cases of mantle cell lymphoma. Researchers also identified a group of patients with a small number of mutations in the tumor whose disease progression was very slow. Thus, knowledge around the genome of these lymphomas might guide the selection of appropriate treatments for each patient.

This work was carried out with funding from the Association for International Cancer Research (United Kingdom), the Lymphoma Research Foundation (USA) and the Instituto de Salud Carlos III (Spain), and illustrates how new genome sequencing technologies are revolutionizing the study of different types of cancer. During the last three years the Spanish Consortium for the Study of the Genome of the Chronic Lymphatic Leukemia, where the researchers of the present study already collaborate, has sequenced the genome of hundreds of patients with the more common leukemia in our society, identifying new mechanisms of tumor progression and new therapeutic targets. These studies should allow the application of genomic studies in clinical practice to improve the diagnosis and treatment of cancer patients.