In utero exposure to diesel exhaust a possible risk factor for obesity

"It is becoming clearer that our environment profoundly affects our health in ways that are little understood," said Jessica L. Bolton, Ph.D., a researcher involved in the work from the Department of Psychology and Neuroscience at Duke University in Durham, NC. "We believe these data have important implications for health disparities as a consequence of socioeconomic conditions, in which low income neighborhoods tend to be disproportionately exposed to high levels of pollution, which we hope will inform policy and regulation decisions."

To make this discovery, Bolton and colleagues used two groups of pregnant female mice, one of which was exposed to diesel exhaust during the latter half of pregnancy. The second group was exposed to filtered air for the same time period. The mice lived in specialized chambers for four hours each day breathing polluted air and then were returned to normal housing after these exposures. Prior to birth, some of the fetal brains of the mice from both groups were analyzed to measure immune proteins and to get a "snap shot" of the fetal brain immune response to the in utero condition. Once the offspring were adults, they were placed on either a low-fat diet (10% saturated fat) or a high-fat diet (45% saturated fat). All other nutritional aspects of the diets were identical.

Scientists measured food intake, body weight and activity levels before putting the mice on their diets, and then weekly throughout the experiment. At the end of six weeks, metabolic hormones were assessed. They found that males from diesel-exposed moms were heavier than the males from clean air-exposed moms regardless of their diet as adults. In contrast, females from diesel-exposed moms were heavier than control females only if they were fed a high-fat diet as adults, and they never developed signs of insulin resistance.

"If you're pregnant and have a long drive into work, you might think twice about opening the car windows," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal. "It's already been established that risk factors for obesity (junk food, high fat-high cholesterol diets, etc.) begin as early as the womb. This important study shows that the air a mother breathes is also one of those risk factors."