Neurotoxins in shark fins: A human health concern

"Shark fins are primarily derived through finning, a practice where by shark fins are removed at sea and the rest of the mutilated animal is thrown back in the water to die," said co-author Dr. Neil Hammerschlag, research assistant professor of Marine Affairs & Policy and director of the RJ Dunlap Marine Conservation Program (RJD) at UM. "Estimates suggest that fins from as many as 70 million sharks end up in soup. As a result, many shark species are on the road to extinction. Because sharks play important roles in maintaining balance in the oceans, not only is shark fin soup injurious to the marine environment, but our study suggests that it is likely harmful to the people who are consuming them."

Seven species of shark were tested for this study: blacknose, blacktip, bonnethead, bull, great hammerhead, lemon, and nurse sharks. Samples were collected from live animals in waters throughout South Florida.

"The concentrations of BMAA in the samples are a cause for concern, not only in shark fin soup, but also in dietary supplements and other forms ingested by humans," says study co-author Prof. Deborah Mash, Director of the UM Miami Brain Endowment Bank. The Bank supports basic and clinical research and holds one of the world's largest collection of postmortem human brains encompassing a wide range of neurological disorders. In 2009, Mash and her co-authors published a study in the journal Acta Neurological Scandinavica, demonstrating that patients dying with diagnoses of Alzheimer's Disease and ALS had unusually high levels of BMAA in their brains, up to 256 ng/mg, whereas normal healthy aged people had no BMAA or only trace quantities of the toxin present. "BMAA was first linked to neurodegenerative diseases in Guam, which resulted in the progressive loss of structure and function of neurons."

The shark study found a similar range and even higher BMAA in the fins tested, levels of between 144 and 1836 ng/mg of BMAA, which overlapped the levels measured in the brains of the Alzheimer's and ALS victims. Coincidentally, this level fits with the BMAA levels in fruit bats examined by Paul Cox in Guam, animals which concentrate BMAA from their diet of cycad seeds. He linked ingestion of fruit bats to the severe ALS/Parkinsonism dementia that afflicted local indigenous people.

"Not only does this work provide important information on one probable route of human exposure to BMAA, it may lead to a lowering of the demand for shark fin soup and consumption of shark products, which will aid ocean conservation efforts," added Hammerschlag.

The project was funded through a donation from the Herbert W. Hoover Foundation. Established in 1990, the foundation takes a leadership role in supporting unique opportunities that provide solutions to issues related to the community, education, and the environment.