Potential vaccine to prevent gastritis, ulcer disease, gastric cancer

Because the colonization of H. pylori has far-reaching health consequences, it represents a significant public health challenge. Current treatments use multiple antibiotics in combination with acid suppression medications to eradicate it. Due to an increase in antibiotic resistance, it is now more difficult to eliminate, and the development of a vaccine as an alternative therapy is of increased interest.

Steven Moss, M.D., is a gastroenterologist at Rhode Island Hospital and lead author of the paper. Moss, who is also a professor of medicine at the Warren Alpert Medical School of Brown University, says, "Normal immune mechanisms fail to eradicate H.pylori, but some prophylactic and therapeutic vaccine strategies using a wide variety of H. pylori antigens have been reported to be successful. The literature, however, does not define the optimal choice of antigen or the best delivery method."

Through an animal model study, Moss and his colleagues utilized a gene-to-vaccine approach, incorporating multiple epitopes (a part of an antigen that is recognized by the immune system) and administered them both intranasally and intramuscularly. The results of the study suggest that when the vaccine was delivered intranasally it was more effective. Moss says, "We found that the multi-epitope vaccine induced a broad immune response that led to a significant reduction in H. pylori colonization."

Anne S. De Groot, M.D., initiated the HelicoVax research program in 2005 in her company, EpiVax, Inc., with funding from a National Institutes of Health small business research award. De Groot comments, "This project illustrates the power of persistence and collaboration between the biotech industry and academe, especially when it comes to emerging infectious disease vaccines."

Moss concludes, "These encouraging, though preliminary, results suggest that further development of an epitope-based mucosal vaccine against H. pylori can potentially lead to a novel approach to prevent H. pylori-associated diseases such as peptic ulcer disease and gastric cancer in humans. We are now receiving further NIH funding to continue this collaboration with URI and EpiVax and are starting to translate this approach from mice to human subjects."

Other researchers involved in the study with Moss include Dong Soo Lee, Woojin Kim, and Songhua Zhang of Rhode Island Hospital and Alpert Medical School; Anne S. De Groot (University of Rhode Island, EpiVax Inc. and Alpert Medical School), Leonard Moise (University of Rhode Island, and EpiVax Inc.) William Martin, of EpiVax, Inc.; Jinhee Lee of the University of Massachusetts Medical School; and Arlin Rogers of the University of North Carolina, Chapel Hill. EpiVax, Inc. is a privately owned vaccine development company in Providence, RI.