Science News
from research organizations
Oncology: Fanconi anemia pathway dysregulated in non-FA cancers
- Date:
- April 19, 2010
- Source:
- Journal of Clinical Investigation
- Summary:
- Individuals with the rare human genetic disease Fanconi anemia have an increased incidence of cancer. In many individuals, disease is caused by mutations in any one of 13 known genes (including FANCL) that generate proteins that function in one common signaling pathway that is known as the FA pathway. Whether this pathway has a role in human cancers in individuals who do not have Fanconi anemia has not been clearly determined.
- Share:
-
FULL STORY
Individuals with the rare human genetic disease Fanconi anemia have an increased incidence of cancer. In many individuals, disease is caused by mutations in any one of 13 known genes (including FANCL) that generate proteins that function in one common signaling pathway that is known as the FA pathway. Whether this pathway has a role in human cancers in individuals who do not have Fanconi anemia has not been clearly determined.
But now, Peiwen Fei and colleagues, at the Mayo Clinic, Rochester, have identified a new form of the protein FANCL, which they named FAVL, that dysregulates the FA pathway in non-FA human tumor cells and acts as a tumor-promoting factor.
The authors therefore conclude that impairment of the FA pathway could contribute to the development of cancer in individuals who do not have Fanconia anemia.
The research appears in the Journal of Clinical Investigation.
Story Source:
Materials provided by Journal of Clinical Investigation. Note: Content may be edited for style and length.
Journal Reference:
- Jun Zhang, Deping Zhao, Hwan Ki Park, Hong Wang, Roy B. Dyer, Wanguo Liu, George G. Klee, Mark A. Mcniven, Donald J. Tindall, Julian R. Molina and Peiwen Fei. FAVL elevation in human tumors disrupts Fanconi anemia pathway signaling and promotes genomic instability and tumor growth. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI40908
Cite This Page:
Journal of Clinical Investigation. "Oncology: Fanconi anemia pathway dysregulated in non-FA cancers." ScienceDaily. ScienceDaily, 19 April 2010. <www.sciencedaily.com/releases/2010/04/100419233601.htm>.
Journal of Clinical Investigation. (2010, April 19). Oncology: Fanconi anemia pathway dysregulated in non-FA cancers. ScienceDaily. Retrieved August 12, 2026 from www.sciencedaily.com/releases/2010/04/100419233601.htm
Journal of Clinical Investigation. "Oncology: Fanconi anemia pathway dysregulated in non-FA cancers." ScienceDaily. www.sciencedaily.com/releases/2010/04/100419233601.htm (accessed August 12, 2026).
Explore More
from ScienceDaily
RELATED STORIES
Dec. 3, 2025 Scientists discovered that the first 100 base pairs of human genes are unusually prone to mutations, especially during the earliest stages of embryonic development. These mosaic mutations often go ...
May 9, 2025 Mutations in FANCX appear to cause a lethal form of Fanconi anemia, a finding that sheds light on unexplained pregnancy loss and offers new avenues for genetic ...
Aug. 1, 2024 A new large study suggests incidence rates continued to rise in successively younger generations in 17 of the 34 cancer types, including breast, pancreatic, and gastric cancers. Mortality trends also ...
Sep. 15, 2022 The rare genetic disease cystinosis is caused by mutations in the gene for a protein called cystinosin. A team of scientists has now solved the structure of cystinosin and determined how mutations ...
Sep. 6, 2022 A study reveals that the incidence of early onset cancers (those diagnosed before age 50), including cancers of the breast, colon, esophagus, kidney, liver, and pancreas among others, has ...
June 8, 2022 Occasionally, single-letter misspellings in the genetic code, known as point mutations, occur. Point mutations that alter the resulting protein sequences are called nonsynonymous mutations, while ...
Never-Before-Seen Vortices Are Swirling Across the Sun
Honeybee Queens May Pass Toxic Chemicals to the Next Generation
This Common Amino Acid May Help the Body Fight Cancer and Viruses
Low-Protein “Longevity Diet” Linked to Fat Loss, Muscle Preservation, and Healthy Aging
