Neural Probe Developed That Will Limit Damage To Cells And Biological Tissue

Findings of the project were published in Nanotechnology 2008 and will be included in an upcoming issue of IEEE Transactions on Biomedical Engineering.

The neural probe, made of gold and iridium oxide nanowires grown vertically on a polymer or titanium substrate, will improve the function and reliability of neural prosthetic devices. It has also displayed superior biocompatibility and mechanical strength compared to similar silicon structures.

“Our goal is to develop functional systems that can simultaneously stimulate nerves or muscle cells and record physiological changes in the human body,” said Hargsoon Yoon, research assistant professor in the College of Engineering and lead researcher on the project. “Our approach can minimize cell damage and even provide higher electrode efficiency than commonly used electrodes.”

Needle probes are used as neural prostheses to help improve quality of life for patients with severe impairments. Current clinical applications of neural prosthetics include cochlear and retinal implants, cardiac pacing and defibrillation, restoration of urinary bladder function, functional electrical stimulation in paralyzed individuals and deep brain stimulation for people with Parkinson’s disease and Tourette syndrome.

The research team, based at the university’s Center for Wireless Nano-, Bio- and Info-Tech Sensor and Systems, developed probes that integrate free-standing, “hetero-structured” nanowires. Hetero-structured means the nanowires have an inner core and outer layer. Made of gold, the inner-core nanowires were grown vertically on titanium and polymer substrates. The outer, functional layer, made of iridium oxide, provides charge storage capacity for neural signal sensing and stimulation.

Researchers repeatedly demonstrated an electrical storage capacity of 48.6 Coulombs per square centimeter. Units of electrical charge are measured in Coulombs. Working with different materials, other major research groups, including teams at Stanford University and University of Southern California, have developed probes with less than half the storage capacity of the University of Arkansas probe.

Because storage capacity is directly related to density of electrical current needed to stimulate nerves and muscle cells, the probe can transfer charge into biological cells and tissues using less voltage – and less battery power – and thus can operate longer with less tissue and cell damage.

“Electrodes with low-charge storage capacity require higher stimulating voltage levels,” Yoon said. “It is this higher voltage that can damage biological tissues and the electrode itself.”

Yoon collaborates with Vijay Varadan, distinguished professor of electrical engineering and director of the university’s High Density Electronics Center, to develop a system that will include nanowire electrodes, wireless communication and a power source for bio-packaging. The wireless network will facilitate closed-loop dynamic adjustments of the system and continuous monitoring of patients during stimulation.

Varadan holds the College of Engineering’s Twenty-First Century Endowed Chair in Nano- and Bio-Technologies and Medicine and the college’s Chair in Microelectronics and High Density Electronics. In addition to his position as director of the above center, he directs the university’s High Density Electronics Center. Varadan is also a professor of neurosurgery in the College of Medicine at the University of Arkansas for Medical Sciences in Little Rock, Ark.