Defining Complications From Organophosphate Poisoning From Pesticides

Prior to this work, the development of IMS in people who have accidentally or intentionally consumed organophosphates was not well understood, and no predictors of its occurrence existed. In an expert commentary on the new study, Cynthia Aaron of the Children's Hospital of Michigan, Detroit, who was not involved in the study, comments "...there has been tremendous controversy in the toxicology world concerning the true definition and existence of IMS as an isolated entity".

Pradeepa Jayawardane and colleagues studied 78 patients with organophosphate poisoning admitted to the Nuwara Eliya General Hospital and Teaching Hospital, Peradeniya in Sri Lanka. All patients were managed in the clinic according to routine procedures. In addition to standard care, the patients were evaluated using a technique called repetitive nerve stimulation, which allowed the researchers to study changes in nerve transmission.

During the study, 10 of the 78 individuals developed IMS. In these individuals, specific changes were seen in the neuromuscular transmission pattern, often before clinical signs of intermediate syndrome developed. Thirty individuals also developed muscle weakness, but not severe enough to diagnose IMS, and these individuals also developed defined changes in their neuromuscular transmission patterns.

The researchers conclude that IMS is a "spectrum disorder"; that is, the syndrome progresses over time through a series of changes which only result in respiratory failure amongst the most severe cases. The researchers also suggest that the clinical signs of IMS are preceded by changes in nerve transmission, which might therefore provide an indicator of future poor outcome.

However, before these findings can be applied directly to clinical care it is important to verify the changes in an independent group of patients. In her commentary, Aaron notes "If these distinctive electrophysiological changes are subsequently validated in further studies, they should lead to improved diagnostic and prognostic tools for clinical use in organophosphate-poisoned patients".