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Jan. 3, 2024 Mutations of the tumor suppressor p53 not only have a growth-promoting effect on the cancer cells themselves, but also influence the cells in the tumor's microenvironment. Scientists have now ...
Apr. 5, 2021 Scientists has illuminated the functions of mysterious structures in cells called 'nuclear speckles,' showing that they can work in partnership with a key protein to enhance the activities ...
Feb. 21, 2024 Researchers have revealed the mechanism of the drug valemetostat shown to be effective in treating certain types of cancer by targeting a protein modification (histone methylation) silencing the ...
Mar. 27, 2024 Scientists reversed an aggressive cancer, reverting malignant cells towards a more normal state. Rhabdoid tumors are an aggressive cancer which is missing a key tumor suppressor protein. Scientists ...
Sep. 16, 2021 In a surprising new finding in mice, researchers have discovered that many genes linked to human cancer block the body's natural defense against ...
Oct. 12, 2021 The immune system protects the body from cancer. To protect healthy body cells from its own immune system, they have developed a protective shield: the protein CD47 is a so called 'don't ...
Nov. 2, 2023 Researchers have identified a signaling pathway by which aspirin can inhibit colorectal ...
Feb. 9, 2022 mRNA nanoparticles effectively and safely restored the function of the p53 tumor-suppressor gene in hepatocellular carcinoma models. When used in combination with immune checkpoint blockade, the mRNA ...
Feb. 13, 2023 New research illuminates the mechanisms at work that prevent the p53 gene from triggering effective cancer cell ...
Aug. 3, 2023 Scientists have developed a nanoengineered bioink with improved bonding and cross-linking capabilities for 3D bioprinted tumor models. These capabilities are enabled by the addition of Laponite, ...