High dietary sodium, potassium may worsen chronic kidney disease

Chronic kidney disease (CKD) is a major public health challenge because it is common, frequently progresses to kidney failure, and increases risk of heart disease and premature death. Diet may play an important role in CKD progression, but little is known about the role of certain dietary components such as sodium and potassium.

To investigate, Jiang He, MD, PhD (Tulane University) and his colleagues collected yearly urine samples from 3939 patient with CKD to estimate the patients' dietary sodium and potassium intake. The researchers found that high urinary excretion levels of both sodium and potassium were linked with faster disease progression. In addition, the study's participants consumed an average of 3700 mg of sodium per day, which is much higher than the recommended 2400 mg per day limit.

"These data warrant future clinical trials to test the effect of a moderate reduction in dietary sodium and potassium intake on CKD progression in patients with high dietary sodium or potassium intake," said Dr. He. "The findings could ultimately impact dietary recommendations for patients with CKD to slow disease progression."