Birch helps wounds heals faster

In the first phase of wound healing, the damaged skin cells release certain substances that lead to a temporary inflammation. They attract phagocytes, which remove foreign bacteria and dead tissue. The Freiburg scientists determined that the birch bark extract, in particular its main ingredient betulin, does in fact temporarily increase the amount of these inflammatory substances. The natural substance activates proteins that extend the half-life of the messenger ribonucleic acid (mRNA). A gene must first be translated into mRNA for the blueprint of a protein to be read by the genome. The substance triples the time in which the mRNA of a particular messenger remains stable. This messenger enables more of the protein in question, in this case the inflammatory substances, to be produced. In addition, the birch bark extract and betulin also stabilize the mRNA of further messengers.

In the second phase of wound healing the skin cells migrate and close the wound. The natural substance aids in this process: The birch cork extract and its components betulin and lupeol activate proteins that are involved in the restructuring of the actin cytoskeleton, which gives the cell its shape with the help of the structural protein actin. In this way, the substances from the birch cause keratinocytes -- the most common type of cell in the outermost layer of skin -- to migrate more quickly into the wound and close it.