Obstructive sleep apnea's damage evident after one month

The model and its findings are the result of efforts undertaken by Randy F. Crossland, David J. Durgan, Eric E. Lloyd, Sharon C. Phillips, Sean P. Marrelli and Robert M. Bryan, Baylor College of Medicine, Houston, Tex. An abstract of their study entitled, "Cerebrovascular Consequences of Obstructive Sleep Apnea," will be discussed at the meeting Experimental Biology 2012 being held April 21-25 at the San Diego Convention Center. The abstract is sponsored by the American Physiological Society (APS), one of six scientific societies sponsoring the conference which last year attracted some 14,000 attendees.

New Model, New Findings

The most common animal model used to study OSA today is intermittent hypoxia (IH) which relies solely on exposing animals to a decrease in blood oxygen levels. The new model incorporates all physiological consequences involved in OSA by inducing true apnea (closure of the airway). The revised model creates a more complete picture of the apnea process and one that more accurately mimics how OSA unfolds in humans.

Using their model the researchers induced 30 apneas (10 seconds duration) per hour in animals for 8-hours during the sleep cycle for up to one month. After one month of apnea, cerebral vessel dilatory function was reduced by up to 22 percent. This finding correlates with studies that show similar cell dysfunction in arteries and an increased risk of stroke in OSA patients. Damage to the vascular wall in brain arteries could be a factor predisposing an individual with OSA to stroke.

"There are two important findings in these results," according to researcher Randy Crossland. "The first is the model itself. The new model allows us to study the complete disease and better understand how repetitive exposure to apnea affects the body. The second is that only one month of moderate OSA produces altered cerebrovascular function which could result in a stroke. A finding that highlights the detrimental impact OSA can have on the body."

OSA Prevalence Expected to Rise

According to Mr. Crossland, some researchers estimate that up to 85 percent of patients with clinically significant sleep apnea have not been diagnosed. Obesity and aging are strongly associated with OSA. "As the prevalence of obesity is rising, and the population continues aging, we expect the rates of OSA to rise. It should also be noted that non-obese individuals and even children can have OSA," he said. And while OSA is seen more often in men than in women for unknown reasons some researchers believe that the true rate in females has been underestimated.

The common signs and symptoms of OSA include: habitual snoring, daytime sleepiness, enlarged neck size, morning headache, sexual dysfunction, and mood and behavioral changes. "OSA can have a detrimental impact on a person's body and their life. It is a serious, yet treatable, disorder that should not be taken lightly," according to Mr. Crossland.