New method for simple fabrication of microperforated membranes

In the AIP journal Biomicrofluidics, Hongkai Wu, a chemist at Hong Kong University of Science and Technology, and his colleagues describe a simple new method using just one photolithographic step to fabricate free-standing polymer membranes with neatly patterned holes as small as 10 microns in diameter.

The researchers start by designing the desired pattern on a computer and printing it on a transparency (for holes larger than 20 microns in diameter) or a chrome mask (for those smaller than 20 microns). "Then," Wu says, "we place two spacers on a flat substrate and between them add a few drops of a prepolymer" -- a molecule that can form into a polymer. The prepolymer is covered with the mask, which is pressed down onto the spacers; ultraviolet light is then used to cure the membrane. The mask is then removed to reveal the free-standing, perforated membrane.

"Because our technique can fabricate membranes of pores with accurate sizes and in arbitrary shapes and sizes, and the fabrication is very easy and fast, we expect them to have many potential applications in different fields," says Wu. "These membranes can be directly used as masks to pattern inorganic, organic, and biological materials like proteins and cells, on various surfaces," he says.

"One important application of the membrane is that it makes it very simple to fabricate 3D microfluidic structures with channels running up and down through the membrane, which are difficult to make otherwise."