Antioxidant In Substance From Honeybees May Protect Athletes From Overheating

Honeybee propolis, or bee glue, has been widely used as a folk medicine. An active ingredient in propolis known as caffeic acid phenethyl ester, or CAPE, has a broad spectrum of biological activities including antioxidant, anti-inflammatory and antiviral. Hyperthermia, or heat stress, is considered to be the main factor underlying the early fatigue and dehydration seen during prolonged exercise in the heat.

“Since hyperthermia and free radical generation are related to exercise-induced physical damage, it is reasonable to test whether an antioxidant can prevent or reduce hyperthermia-induced free radical generation and damage,” says lead researcher Yu-Jen Chen of Chinese Culture University in Taiwan.

Researchers examined blood from 30 competitive cyclists who engaged in endurance training for two to four years prior to the investigation. None participated in any competitions or intensive training or had any clinical illness or medical or surgical treatments four months prior to the study.

“CAPE rescued mononuclear cells from hyperthermia-induced cell death,” writes Yu-Jen Chen. “This implies that CAPE might not only promote athletic performance but also prevent injury secondary to endurance-exercise-induced hyperthermia.” In addition, researchers indicated that further human studies need to be conducted to solidify their findings.