New Catalysts Promise Faster, Cleaner And More Efficient Research Platform

The new catalysts can be easily prepared and possess unique features never before utilized by chemists, according to findings from a team led by Boston College Prof. Amir H. Hoveyda and MIT Prof. and Nobel laureate Richard Schrock, who shared the 2005 prize in Chemistry for early discoveries of catalytic olefin metathesis. The team's findings are reported in the current online edition of the journal Nature.

"In order for chemists to gain access to molecules that can enhance the quality of human life, we need reliable, highly efficient, selective and environmentally friendly chemical reactions," said Hoveyda, the Joseph T. and Patricia Vanderslice Millennium Professor and Chemistry Department chairman at BC. "Discovering catalysts that promote these transformations is one of the great challenges of modern chemistry."

Catalytic olefin metathesis transforms simple molecules into complex ones. But a chief challenge has been developing catalysts to this organic chemical reaction that are practical and offer exceptional selectivity for a significantly broader range of reactions.

Schrock, the Frederick G. Keyes Professor of Chemistry at MIT, said the unprecedented level of control the new class of catalysts provides will advance research across multiple fields.

"We expect this highly flexible palette of catalysts to be useful for a wide variety of catalytic reactions that are catalyzed by a high oxidation state alkylidene species, and to be able to design catalytic metathesis reactions with a control that has rarely if ever been observed before," Schrock said.

Highly versatile molecules that contain carbon–carbon double bonds, alkenes, or olefins, are ubiquitous in medicinally relevant and biologically active molecules. Tetrahedral in constitution, the new catalysts are the first to exploit a metal with four different ligands – molecules that bond to the central metal – which in turn dictate the catalysts' high level of reactivity and selectivity.

"For the first time these catalysts take advantage of the configuration of a metal with four different ligands attached to it, an untested situation that has long been predicted to be a strong director of asymmetric catalytic reactions that take place at the metal center," said Schrock.

Unique to this catalyst is the metal molybdenum as a source of chirality, also known as "handedness." Like the mirror image of left hand and right, molecules can come in two variations, one a reflection of the other. But these two variations often function in entirely different ways – sometimes one proves harmful, while the other is benign.

With molybdenum at its core, the new catalyst gives chemists a simple, unique and efficient way to produce one form of the molecule or the other in order to yield the desired reactions.

The new catalysts are also structurally flexible, a relatively unconventional attribute that lends them exceptional chemical activity. The discovery of catalysts with stable configurations and flexible structures is expected to allow chemists to design, prepare and develop new chemical transformations that furnish unprecedented levels of reactivity and selectivity, according to the co-authors, which include BC researchers Steven J. Malcolmson, Simon J. Meek, and Elizabeth S. Sattely.

The findings mark the latest discovery from the long-standing collaboration between the Hoveyda and Schrock labs, work that has been supported by more than $3.5 million in funding from the National Institutes of Health for nearly a decade.