Neuronal Conduction Of Excitation Without Action Potentials Based On Ceramide Production

This new mechanism involves molecules known to play a role in numerous mechanisms of cell functioning, but not hitherto in conduction of excitation. To elucidate this mechanism, the teams have used a model of integrated physiology on an in vitro preparation in the mammal. This study has been performed using neuropharmacological and biochemical techniques.

This study, reporting the first discovery of conduction of excitation without action potentials, opens up new perspectives for research by breaking away from the classic concept of neuronal functioning. The neurons would thus be fitted with two modes of conduction of excitation, fast and slow, which might be used in different circumstances. This would have important consequences in the fields of physiological research and clinical practice.

Researchers are as follows: from the Laboratoire de Physiologie Neurovégétative (CNRS-INRA-Université Paul Cézanne), the Laboratoire de Chimie Biologique Appliquée (INRA-Université Paul Cézanne) and from the Département Lipoprotéines et Médiateurs Lipidiques (INSERM, Hopital Purpan Toulouse), and in particular Professor Jean-Pierre Miolan, Dr Jean-Pierre Niel, Directeur de Recherche CNRS, Dr François Tercé, Chargé de Recherche INSERM, Dr Abel Hiol Maître de conférence and Dr Caroline Fasano.

Citation: Fasano C, Tercé F, Niel J, Nguyen HTT, Hiol A, et al. (2007) Neuronal Conduction of Excitation without Action Potentials Based on Ceramide Production. PLoS One 2(7): e612. doi:10.1371/journal.pone.0000612).