Scientists Explore How Complex Organs Develop From A Simple Bud

Key questions within the reviews --pertaining to the maintenance and repair of cells within adult branched organs, the role of cells only transiently associated with adult organs, and the extent to which defects in the growth and development of fetal stage organs can affect organ function after birth -- have important implications for human health.

Two of the reviews in the Journal delve into tubulogenesis – a process that is intimately tied to branching morphogenesis. Another contains research aimed at helping patients whose salivary glands have been injured by radiation therapy or autoimmune rejection. An investigation into the morphogenesis of the prostate gland and seminal vesicles is included, as well as an in-depth look at the genetic and cellular interactions critical to placental development. Research on this process in mouse kidneys generated a real-time tracking procedure which has significant implications for genetic manipulation.

Ultimately, scientists hope analysis of branching morphogenesis will lead to the design of a computer program that is able to virtually reconstruct the complete process of organogenesis –from simple bud to complex organ. The reviews in this special issue of Differentiation are written by top scientists offering fresh ideas and pertinent background information to readers interested in anything from molecular to cellular and developmental biology.

Differentiation is a multidisciplinary journal dealing with all problems relating to cell differentiation, development, cellular structure and function, and cancer. Differentiation of eukaryotes at the molecular level and the use of transgenic and targeted mutagenesis approaches to problems of differentiation are of particular interest to the journal. It publishes full-length articles containing original work in any of these areas, as well as reviews on topics of current interest in the field.