University Of Pittsburgh Studies Broccoli-derived Chemicals To Prevent Prostate Cancer

UPCI researcher Shivendra Singh, Ph.D., professor of pharmacology and urology at the University of Pittsburgh School of Medicine, has received a $1.7 million grant from the National Cancer Institute to study prostate cancer prevention by phytochemicals found in broccoli called isothiocyanates (ITCs).

"Clearly, what we eat has an effect on the development of diseases such as cancer," said Dr. Singh, also co-leader of UPCI's cancer biochemoprevention program. "However, we know little about the mechanisms by which certain edible plants like broccoli help our bodies fight prostate cancer and other diseases. Our goal with this study is to better understand the function and relationship of substances in broccoli that appear to be linked to inhibiting prostate cancer growth."

ITCs are substances in vegetables that are generated when vegetables are either cut or chewed. Previous research has demonstrated that ITCs are highly effective in affording protection against cancer in animal models induced by carcinogens including those in tobacco smoke. Epidemiological research also has shown that increased consumption of vegetables that contain ITCs significantly reduces the risk for prostate cancer.

Dr. Singh's laboratory has found that some naturally occurring ITCs are highly effective in suppressing the growth of human prostate cancer cells at concentrations that are achievable through dietary intake of cruciferous vegetables such as watercress and broccoli. In his current study, Dr. Singh seeks to further define the mechanisms by which ITCs induce apoptosis, or cancer cell death, to provide insights into the key structural relationships between ITCs and cell processes and to identify potential biomarkers that could be useful for future intervention trials involving ITCs.

"The knowledge we gain from this study will help guide us in formulating practical and effective nutritional strategies for the prevention and treatment of prostate cancer," said Dr. Singh. In addition to studies involving broccoli, Dr. Singh also is examining the effect of garlic on prostate cancer prevention.

In the United States, only 23 percent of adults eat five or more fruits and vegetables per day.