Breast MRI after mammography may identify additional aggressive cancers

Breast MRI is the most sensitive technique for the detection of breast cancer, with widespread application in the screening of high-risk patients and pre-surgical planning. In younger women and women with dense breasts, MRI is effective in the detection of what are known as multicentric cancers, meaning breast cancers involving two or more distinct primary tumors, usually in different quadrants of the breast. However, there has been some debate about the clinical significance of multicentric cancers found with MRI.

"Patients with clinically insignificant cancers undergoing potential overtreatment versus patients who may be undertreated is at the heart of the controversy surrounding breast MRI," said the study's lead author Chiara Iacconi, M.D., from the Breast Unit at USL1 Massa-Carrara in Carrara, Italy.

To learn more, Dr. Iacconi and colleagues reviewed records from 2,021 patients with newly diagnosed breast cancer who underwent biopsy after preoperative MRI. Of the 2,021 patients, 285, or 14 percent, had additional cancer detected on MRI that was hidden from view on mammography.

In 73 of those 285 patients, or 25.6 percent, MRI identified at least one additional cancer in a different quadrant of the breast than the index cancer, or the cancer detected by mammography and/or breast palpation.

These multicentric cancers were larger than the known index cancer in 17 of the 73 patients, or 23.3 percent. In addition, the MRI-detected multicentric cancers were greater than 1 centimeter in size in 25 percent of the 73 patients.

"We believe invasive cancer larger than 1 centimeter is clinically relevant disease," Dr. Iacconi said. "In general, it is accepted that radiation can likely treat invasive cancer less than 1 centimeter, but lesions larger than 1 centimeter, especially invasive carcinomas, may not be reliably treated with conservation."

The additional MRI-detected multicentric cancers were found mostly in patients with heterogeneously dense or extremely dense breasts. However, MRI also detected additional disease in 19 percent of patients with fatty or scattered fibroglandular tissue.

"The results show that multicentric cancer detected on breast MRI after mammography appears to represent a larger tumor burden in approximately a quarter of patients and can result in potential changes to cancer grade and treatment," Dr. Iacconi said.