HIV reservoirs remain obstacles to cure

In a new perspective article, National Institute of Allergy and Infectious Diseases (NIAID) Director Anthony S. Fauci, M.D., and colleagues describe how persistent HIV reservoirs form in the human body and why they pose formidable challenges to achieving a cure.

Additionally, the authors discuss the current therapeutic research strategies aimed at eliminating or controlling the virus without daily ART, including making CD4+ T cells resistant to HIV and enhancing host immunity against infection. A better understanding of persistent viral reservoirs and the impact of therapeutic interventions on these reservoirs is essential to the development of successful therapeutic strategies aimed at the long-term control of HIV infection, according to the authors.

While recent scientific advances and increased funding aimed at developing therapeutic strategies toward an HIV cure have yielded valuable insights into the pathogenesis of HIV-related disease, achieving an HIV cure remains extremely challenging, the authors note. However, recent advances give cause for hope. Attaining a cure will require strong and sustained efforts to better understand the establishment, composition, maintenance, and renewal of HIV reservoirs, according to the authors.