Shutting off blood supply to extremity to protect heart

The research group wanted to see how the muscle of the left chamber of the heart was affected by a technique, called RIPC (remote ischemic preconditioning), during cardiac surgery.

RIPC works by shutting off the blood supply to an arm or a leg before heart surgery. The goal is to reduce risk during cardiac surgery in the future. The technique is not new, but its effects have never before been tested directly on the left chamber of the heart.

"During heart surgery we have to stop the blood supply to the heart to be able to operate on it. After some time without fresh blood, the heart will reduce its ability to produce energy because it doesn't get oxygen. When we shut off the bloodflow to another large muscle, such as an arm or a leg, the body prepares for an upcoming challenge by mobilizing its defense system," says the first author of the study, Katrine Hordnes Slagsvold, a PhD candidate at NTNU and medical doctor at St. Olavs Hospital.

The researchers investigated cardiac tissue from 60 patients who had coronary bypass surgery at St. Olavs Hospital in Trondheim. The patients were randomized to either undergo RIPC, or to a control group. Patients who were treated with RIPC underwent brief periods without blood supply to the arm before surgery, by inflating a blood pressure cuff for five minutes three times.

"The heart muscle of the patients who had restricted blood flow to their arm before surgery were able to maintain the same level of energy production during the whole operation, while heart muscle from the other patients' hearts was not. This may be important because heart tissue is dependent on energy to survive, as well as to repair injuries the cells may have endured during surgery," Slagsvold says.

The researchers also found that a protein called Akt was activated after RIPC, and believe that activation of this protein may be key in inducing the protective effect on the heart.