Gene that influences receptive joint attention in chimpanzees gives insight into autism

The study results, which are published in Scientific Reports, give researchers insight into the biology of disorders in which receptive joint attention is compromised, such as autism spectrum disorders (ASD), and may ultimately lead to new diagnosis and treatment strategies.

According to Yerkes researchers Larry Young, PhD, and Bill Hopkins, PhD, co-authors of the study, receptive joint attention is important for developing complex cognitive processes, including language and theory of mind, and poor joint attention abilities may be a core feature in children with or at risk of developing ASD.

Young is division chief of Behavioral Neuroscience and Psychiatric Disorders at Yerkes, director of the Center for Translational Social Neuroscience (CTSN) at Emory and William P. Timmie Professor in the Emory University School of Medicine Department of Psychiatry and Behavioral Sciences. Yerkes researcher Hopkins is also a core faculty member in the Neuroscience Institute of Georgia State University and newly named science director of the Iowa Primate Learning Sanctuary.

Young and Hopkins led a collaborative team of researchers from Yerkes, the CTSN, the Neuroscience Institute at Georgia State University and the University of Texas M.D. Anderson Cancer Center. They studied chimpanzees to determine the extent to which the animals follow gaze or pointing by a human.

"We used chimpanzees in this behavioral study because their receptive joint attention abilities are well documented and their closeness to humans makes the study results the most likely to be generalizable to humans," says Hopkins.

Young's previous research in which he showed the vasopressin receptor gene was necessary for remembering individuals (or social memories) and for social bonding in male rodents was key to designing the current study. According to Young, variation in the length of a stretch of repetitive DNA, known as junk DNA, in the control region of the vasopressin receptor gene predicted if a male prairie vole was likely to form monogamous bonds with a mate. Human-based studies suggest that a similar repetitive element, referred to as RS3, in the control region of the human vasopressin receptor gene predicts romantic relationship quality and generosity.

The current research team discovered about two-thirds of chimpanzees are completely missing the RS3 element that seems to influence social relationships in humans, while the remaining one third has the human-like sequence.

"Male chimpanzees with the human-like RS3 sequence displayed higher levels of joint attention and, therefore, needed fewer social cues to elicit an orienting response in the same direction as the experimenter than those missing the sequence," says Hopkins. "There was no effect of this gene in female chimpanzees, consistent with the vole and human studies in which the vasopressin gene specifically affects male social behaviors," Young adds.

A previous study by Hopkins and his M.D. Anderson-based colleagues found male chimpanzees with the human-like RS3 sequence were more dominant than males lacking the RS3. Hopkins and Young speculate this dominance may be achieved because the males with RS3 are more socially competent at reading communicative cues of others. "They are more socially savvy and, thus, may be more likely to negotiate social hierarchies more efficiently," says Hopkins.

"The unusual genetic variation in the RS3 of chimpanzee vasopressin receptor gene makes chimpanzees an excellent animal model for exploring the role of the vasopressin receptor on social behaviors and, hopefully, translating our findings to humans," says Young. "We can provide insights into the evolution of human social behaviors, and because of the similarities between chimpanzees and humans, we can work toward better understanding the role of biological mechanisms and how they influence cognitive and communicative abilities of primates, including humans," Young continues.

The team's continuing work will include more sophisticated behavioral studies as well as exploration of the contribution of the oxytocin receptor gene on social behavior and cognition in chimpanzees.