Probiotics reduce piglet pathogens

"We found a clear reduction of E. coli strains possessing typical genes for extra-intestinal pathogenic E. coli (ExPEC)," says Bednorz. The reduction was particularly noticeable in strains that adhere to the intestinal mucosa (and less so in the feces), which was "very interesting," she says, because "ExPEC typically harbor a lot of adhesion genes that promote colonization of the mucosa."

Antimicrobials are thought to promote growth in industrially grown livestock because without them, the rationale goes, in such close quarters, a surfeit of pathogens would slow growth. "Our data suggest that the feeding of probiotics could substitute for antimicrobials as growth promoters," says Bednorz. "This could help to reduce the burden of antimicrobial resistance," she adds.

In previous studies, the working groups from the Institute of Microbiology and Epizootics at Freie Universitat Berlin found that feeding E. faecium probiotic did not change the general swine intestinal microbiota, but reduced infections by Chlamydia spp. and pathogenic E. coli, according to the report.

In the study, Bednorz and her collaborators compared piglets fed with E. faecium to those in a control group. They collected more than 1,400 samples of E. coli from piglets of different ages, and from different parts of the intestine.

While a number of strains of E. coli are pathogenic, non-pathogenic E. coli "contributes to the maintenance of the microbial gut balance," according to the report. These were relatively unaffected by the feeding of E. faecium, which "did not influence the overall intestinal E. coli diversity, corroborating previous data," according to the report. Thus, the researchers conclude, the results suggest that E. faecium inhibits pathogenic E. coli from becoming attached to the intestinal mucosa.