Poultry vaccination responsible for dramatic fall in Salmonella infections

Salmonella are important food-borne pathogens worldwide, causing diarrhea, vomiting, nausea, fever and abdominal pain. There are currently around 6 million cases of illness from Salmonella across the EU each year, the majority of which are linked to food items such as eggs, chicken, beef, pork, salad vegetables and dairy products.

Between 1981 and 1991, the number of salmonella infections rose by 170% in the UK, driven primarily by an epidemic of Salmonella Enteritidis which peaked in 1993. A raft of control measures were introduced into the poultry industry including movement restrictions, compulsory slaughter and disinfection procedures, as well as a voluntary industry-led vaccination scheme that began in breeding flocks in 1994 and in laying flocks in 1998.

Code of Practice

Legislation requiring compulsory slaughter of poultry infected with Salmonella has now been revoked but the mass vaccination of poultry has continued by those breeders subscribing to the Lion Quality Code of Practice and using the Lion Mark on eggs. The code of practice requires mandatory vaccination of all young hens destined to lay Lion eggs against Salmonella, as well as traceability of hens, eggs and feed, a best-before date stamped on shells and hygiene controls at packing stations. Lion eggs now account for around 85% of the total market.

Sarah O'Brien, Professor of Epidemiology and Zoonoses, from the University's Institute of Infection and Global Health, attributes a dramatic fall in the number of Salmonella cases in humans to this mass vaccination programme in poultry.

Professor O'Brien said: "We have seen a marked decline in the number of incidents of Salmonella infection, shown by two significant studies conducted 10 years apart. These studies found that the number of cases fell from 1.6 cases per 1,000 person years for a study conducted from 1993 to 1996 (1) to 0.2 cases per 1,000 person years for the same study conducted from 2008 to 2009 (2).

"In addition, the number of laboratory-confirmed cases of illness dropped from more than 18,000 in 1993 to just 459 in 2010 (3).

"The nature of public health interventions often means that evaluating their impact is complex as they are often implemented simultaneously. The decrease in laboratory confirmed human cases coincides quite closely with the introduction of vaccination programmes in breeder and laying flocks. It is probable that no single measure contributed to the decline in Salmonella cases but the relationship between vaccination programmes and the reduction in human disease is compelling and suggests these programmes have made a major contribution to improving public health."

The research is published in Clinical Infectious Diseases.

Notes:

1. Tam CC, Rodrigues LC, Viviani L et al. Longitudinal study of infectious intestinal disease in the UK (IID2 study): incidence in the community and presenting to general practice. Gut 2012; 61(1): 69-77.

2. Wheeler JG, Sethi D, Cowden JM et al. Study of infectious intestinal disease in England: rates in the community, presenting to general practice, and reported to national surveillance. The Infectious Intestinal Disease Study Executive. BMJ 1999; 318(7190): 1046-5

3. Laboratory reports of human Salmonella cases in the UK, 1981 to 2010 -- Health Protection Agency; Health Protection Scotland; Public Health Agency of Northern Ireland