Brain Plasticity: Changes And Resets In Homeostasis

Homeostasis, the body's own mechanism of regulating and maintaining internal balance in the body, is necessary for survival. Precisely how the brain pulls off this tricky balancing act has not been well appreciated.

By examining neural circuits that regulate fluid volume, Jaideep Bains, PhD, and colleagues, Brent Kuzmiski, PhD, and Quentin Pittman, PhD, have demonstrated that multiple forms of synaptic plasticity work to ensure that an effective response to a life-threatening challenge is followed by an immediate recovery of these neural circuits to pre-challenge conditions.

These observations provide the first set of synaptic rules that help us understand how homeostatic setpoints are re-set in vivo. Based on their findings, Bains and colleagues, demonstrate that synaptic plasticity is essential for maintaining stability in a nervous system constantly bombarded by inputs from the outside world.

This research was supported by the Canadian Institutes of Health Research (CIHR) and the Heart and Stroke Foundation of Alberta, Yukon and NWT. Bains is an AHFMR (Alberta Heritage Foundation for Medical Research) senior scholar while Pittman is an AHFMR medical scientist. Bains is an associate professor and Pittman a professor in the Department of Physiology and Biophysics. Both are members of the Hotchkiss Brain Institute in the Faculty of Medicine at the University of Calgary.