Asymptomatic Peripheral Artery Disease Prevalence Is Rising

"We were interested in seeing if the prevalence of peripheral artery disease in the general U.S. population is increasing, specifically among people who don't have known coronary artery disease," said Andrew D. Sumner, M.D., lead author of the study and a cardiologist and medical director of the Heart Station and Cardiac Prevention at Lehigh Valley Hospital in Allentown, Pa.

Researchers hypothesized that the prevalence of asymptomatic PAD is increasing and the escalation is associated with a rise in the prevalence of other common cardiovascular risk factors, including diabetes, smoking, obesity and hypertension.

Sumner and colleagues analyzed data from three successive National Health and Nutrition Examination Surveys (NHANES), conducted in two-year increments between 1999 and 2004. They identified PAD prevalence by identifying people with an ankle-brachial index of less than 0.9.

"The ankle-brachial index measures the ratio of the blood pressure in the arms and legs, and if it is less than 0.9, people by definition have PAD," he said.

The researchers then examined the prevalence of associated cardiac risk factors of obesity, diabetes, hypertension and smoking in 5,376 participants, age 40 and older, with no prior history of cardiovascular disease. They found that PAD prevalence among asymptomatic adults 40 years and older significantly increased from 3.7 percent in the 1999-2000 survey to 4.2 percent in the 2001-02 survey and 4.6 percent in the 2003-04 survey.

"PAD prevalence was highest among those age 70 and older," Sumner said. "But there also was an increase in the prevalence in each adult age group, including 40 to 49, 50 to 69 and greater than 70 years." The authors said prevalence of obesity, diabetes, hypertension and smoking also increased over these three surveys.

"PAD is affecting more people in the United States and will continue to do so because the prevalence of this problem increases as we get older, and we have an aging population," Sumner said. "And this increase is associated with an increase in common cardiac risk factors."

Consumers should be aware that while they might not have symptoms, they could have PAD and should discuss risk factors and the possibility of screening with their doctors, Sumner said.

Doctors, on the other hand, should note that PAD prevalence is rising and that many of the accompanying risk factors, such as hypertension, can be treated.

"Doctors need to be looking for PAD in asymptomatic patients," he said. "And we need to more aggressively address the risk factors associated with this increase in prevalence."

The next step, from a public health perspective, is to reassess the protocols and systems that exist for evaluating PAD in asymptomatic people, he said.

Co-authors are Sherrine Eid, M.P.H.; Allison Parks, B.A.; Bree Edris, B.A.; and James F. Reed, III, Ph.D.