Researchers Consider Possible Mechanistic Links Between Obesity And Asthma

In the May issue of the Journal of Allergy and Clinical Immunology, researchers from the Physiology Program at the Harvard School of Public Health describe factors that may contribute to this link between obesity and asthma. In obese people the lungs are under-expanded and the size of breaths is smaller. These factors make it more likely that their airways will narrow. In addition, there is chronic low grade systemic inflammation in the obese. This systemic inflammation appears to originate in fat tissue. Inflammation can affect the smooth muscle in the airways causing the airways to narrow excessively.

There are also changes in the blood levels of hormones derived from fat tissue in the obese that may affect the airways. One of these hormones, leptin, is pro-inflammatory and obese individuals have higher leptin levels than lean individuals. Leptin is found at higher levels among asthmatics regardless of the extent of obesity. In contrast, blood levels of another hormone, adiponectin, which has anti-inflammatory properties, are actually lower among obese individuals.

Jeffrey Fredberg, a co-author of the study and professor of bioengineering and physiology at the Harvard School of Public Health commented, "Obesity has the capacity to impact lung function in a variety of ways. None of them are good and all of them are poorly understood. More research is needed to explain the relationship between asthma and obesity."

Research on the link between obesity and asthma in the authors' labs is supported through grants from the National Institutes of Health and the National Institute of Environmental Health Sciences.

Harvard School of Public Health is dedicated to advancing the public's health through learning, discovery, and communication. More than 300 faculty members are engaged in teaching and training the 900-plus student body in a broad spectrum of disciplines crucial to the health and well being of individuals and populations around the world. Programs and projects range from the molecular biology of AIDS vaccines to the epidemiology of cancer; from risk analysis to violence prevention; from maternal and children's health to quality of care measurement; from health care management to international health and human rights. For more information on the school visit: www.hsph.harvard.edu