https://www.sciencedaily.com/news/mind_brain/huntington's_disease/ Read the latest research news on Huntington's Disease. Learn about genetic risks, potential new treatments and more. en-us Mon, 09 Mar 2026 00:38:16 EDT Mon, 09 Mar 2026 00:38:16 EDT 60 https://www.sciencedaily.com/images/scidaily-logo-rss.png https://www.sciencedaily.com/news/mind_brain/huntington's_disease/ For more science news, visit ScienceDaily. https://www.sciencedaily.com/releases/2026/03/260306145621.htm Researchers have discovered a new way to increase a key brain protein damaged in Rett syndrome, a rare genetic disorder that affects thousands of children worldwide. Early studies in mice and patient-derived cells show the approach can restore normal brain cell function, raising hopes for future therapies. Fri, 06 Mar 2026 21:18:09 EST https://www.sciencedaily.com/releases/2026/03/260306145621.htm https://www.sciencedaily.com/releases/2026/01/260116035348.htm Researchers have identified OTULIN, an immune-regulating enzyme, as a key trigger of tau buildup in the brain. When OTULIN was disabled, tau vanished from neurons and brain cells remained healthy. The findings challenge long-held assumptions about tau’s necessity and highlight a promising new path for fighting Alzheimer’s and brain aging. Scientists now believe OTULIN may act as a master switch for inflammation and age-related brain decline. Fri, 16 Jan 2026 03:53:48 EST https://www.sciencedaily.com/releases/2026/01/260116035348.htm https://www.sciencedaily.com/releases/2026/01/260106001913.htm Many people with multiple sclerosis struggle with balance and coordination, and this study uncovers a hidden reason why. Researchers found that inflammation in the brain disrupts the energy supply of vital movement-controlling neurons. As their mitochondria fail, these cells weaken and eventually die, worsening motor problems over time. Protecting brain energy systems could open the door to slowing these symptoms. Tue, 06 Jan 2026 03:18:40 EST https://www.sciencedaily.com/releases/2026/01/260106001913.htm https://www.sciencedaily.com/releases/2025/12/251222080119.htm New research suggests Alzheimer’s may start far earlier than previously thought, driven by a hidden toxic protein in the brain. Scientists found that an experimental drug, NU-9, blocks this early damage in mice and reduces inflammation linked to disease progression. The treatment was given before symptoms appeared, targeting the disease at its earliest stage. Researchers say this approach could reshape how Alzheimer’s is prevented and treated. Mon, 22 Dec 2025 08:11:02 EST https://www.sciencedaily.com/releases/2025/12/251222080119.htm https://www.sciencedaily.com/releases/2025/11/251126095023.htm Spermine, a small but powerful molecule in the body, helps neutralize harmful protein accumulations linked to Alzheimer’s and Parkinson’s. It encourages these misfolded proteins to gather into manageable clumps that cells can more efficiently dispose of through autophagy. Experiments in nematodes show that spermine also enhances longevity and cellular energy production. These insights open the door to targeted therapies powered by polyamines and advanced AI-driven molecular design. Thu, 27 Nov 2025 07:35:52 EST https://www.sciencedaily.com/releases/2025/11/251126095023.htm https://www.sciencedaily.com/releases/2025/11/251106213552.htm Scientists have discovered a surprising benefit of the acne drug doxycycline: it may lower the risk of schizophrenia. Teens prescribed the antibiotic were about one-third less likely to develop the condition as adults. The effect could stem from the drug’s ability to reduce brain inflammation. Researchers say the findings highlight an unexpected new direction in mental health prevention. Thu, 06 Nov 2025 21:44:15 EST https://www.sciencedaily.com/releases/2025/11/251106213552.htm https://www.sciencedaily.com/releases/2025/10/251020092828.htm Scientists at UCSF have uncovered evidence that multiple sclerosis silently damages the brain years before diagnosis. By studying proteins in blood samples, they identified early immune signals and markers of nerve damage. The findings point to IL-3 and MOG as crucial early indicators — and open the door to new diagnostic blood tests and preventive strategies. Tue, 21 Oct 2025 03:14:36 EDT https://www.sciencedaily.com/releases/2025/10/251020092828.htm https://www.sciencedaily.com/releases/2025/10/251014014312.htm Researchers have synthesized enhanced vitamin K analogues that outperform natural vitamin K in promoting neuron growth. The new compounds, which combine vitamin K with retinoic acid, activate the mGluR1 receptor to drive neurogenesis. They also efficiently cross the blood-brain barrier and show stability in vivo. This discovery could pave the way for regenerative treatments for Alzheimer’s and related diseases. Tue, 14 Oct 2025 11:08:36 EDT https://www.sciencedaily.com/releases/2025/10/251014014312.htm https://www.sciencedaily.com/releases/2025/10/251011102259.htm Researchers have identified two compounds, K102 and K110, that could repair the nerve damage from multiple sclerosis. These drugs help regenerate the protective myelin sheath and balance immune responses. Licensed by Cadenza Bio, the discovery represents a leap from lab research to potential clinical therapy. If successful, it could transform how neurodegenerative diseases are treated. Sat, 11 Oct 2025 10:22:59 EDT https://www.sciencedaily.com/releases/2025/10/251011102259.htm https://www.sciencedaily.com/releases/2025/09/250922074952.htm A new study has revealed that TSPO, a protein linked to brain inflammation, rises long before Alzheimer’s symptoms appear. Researchers tracked the protein in genetically engineered mice and confirmed the results in human brain tissue from Colombian families with a known Alzheimer’s mutation. They found unusually high levels of TSPO in microglia clustered around plaques, particularly in women. This discovery not only deepens our understanding of the disease but also sparks the possibility of using TSPO to detect and treat Alzheimer’s far earlier than ever before. Mon, 22 Sep 2025 23:03:39 EDT https://www.sciencedaily.com/releases/2025/09/250922074952.htm https://www.sciencedaily.com/releases/2025/08/250811104227.htm Scientists have discovered a direct cause-and-effect link between faulty mitochondria and the memory loss seen in neurodegenerative diseases. By creating a novel tool to boost mitochondrial activity in mouse models, researchers restored memory performance, suggesting mitochondria could be a powerful new target for treatments. The findings not only shed light on the early drivers of brain cell degeneration but also open possibilities for slowing or even preventing diseases like Alzheimer’s. Tue, 12 Aug 2025 04:02:29 EDT https://www.sciencedaily.com/releases/2025/08/250811104227.htm https://www.sciencedaily.com/releases/2025/05/250528131846.htm Researchers have developed a way to edit the genetic sequences at the root of Huntington's disease and Friedreich's ataxia. If longer than a certain threshold length, these sequences grow in length uncontrollably and lead to brain cell death in Huntington's disease, and the breakdown of nerve fibers in Friedreich's ataxia. There are no treatments that stop the progression of these diseases. Using base editing, the team introduced single-letter changes into the middle of the repeated stretch of DNA, interrupting the sequence in patient cells and mouse models of Huntington's disease and Friedreich's ataxia. They found that the edited DNA tracts stayed the same in length or even became shorter over time. Wed, 28 May 2025 13:18:46 EDT https://www.sciencedaily.com/releases/2025/05/250528131846.htm https://www.sciencedaily.com/releases/2025/05/250528131549.htm Scientists found that stabilizing stress granules suppresses the effects of ALS-causing mutations, correcting previous models that imply stress granules promote amyloid formation. Wed, 28 May 2025 13:15:49 EDT https://www.sciencedaily.com/releases/2025/05/250528131549.htm https://www.sciencedaily.com/releases/2025/05/250514111342.htm In many neurodegenerative diseases, proteins misfold and clump together in brain tissue. Scientists developed a new therapy made of peptides and a sugar that naturally occurs in plants. The therapeutic molecules self-assemble into nanofibers, which bond to the neuron-killing proteins. Now trapped, the toxic proteins can no longer enter neurons and instead harmlessly degrade. Wed, 14 May 2025 11:13:42 EDT https://www.sciencedaily.com/releases/2025/05/250514111342.htm https://www.sciencedaily.com/releases/2025/05/250505171020.htm Researchers found that inhibiting GSK-3 led to less defects in the axonal transport process and less neuronal cell death, while inhibiting ERK1 led to more transport problems and more cell death. Mon, 05 May 2025 17:10:20 EDT https://www.sciencedaily.com/releases/2025/05/250505171020.htm https://www.sciencedaily.com/releases/2025/04/250428220427.htm Prions transmit their abnormally folded shape onto other proteins. Researchers designed a synthetic fragment of the tau protein that exhibits prion-like behavior. Misfolded tau proteins are the hallmark of many neurodegenerative diseases, including Alzheimer's disease and frontotemporal dementia. Study revealed crucial role of water organization in the tau misfolding process. Mon, 28 Apr 2025 22:04:27 EDT https://www.sciencedaily.com/releases/2025/04/250428220427.htm https://www.sciencedaily.com/releases/2025/04/250410130914.htm Marathon runners experience reversible changes in their brain myelin. These findings indicate that myelin (a substance that surrounds the neurons) exhibits behavior that was previously unknown, and that it contributes towards the brain's energy metabolism when other sources of energy are running low. Understanding how myelin in the runners recovers quickly may provide clues for developing treatments for demyelinating diseases such as multiple sclerosis. Thu, 10 Apr 2025 13:09:14 EDT https://www.sciencedaily.com/releases/2025/04/250410130914.htm https://www.sciencedaily.com/releases/2025/04/250408121324.htm Experimental drug NU-9 -- a small molecule compound approved by the U.S. Food and Drug Administration (FDA) for clinical trials for the treatment of amyotrophic lateral sclerosis (ALS) -- improves neuron health in animal models of Alzheimer's disease, according to a new study. Tue, 08 Apr 2025 12:13:24 EDT https://www.sciencedaily.com/releases/2025/04/250408121324.htm https://www.sciencedaily.com/releases/2025/04/250407114004.htm New research shows that the adult brain can generate new neurons that integrate into key motor circuits, findings that may point to a new way to treat neurogenerative disorders. Mon, 07 Apr 2025 11:40:04 EDT https://www.sciencedaily.com/releases/2025/04/250407114004.htm https://www.sciencedaily.com/releases/2025/02/250227165417.htm Using an animal model of multiple sclerosis (MS), researchers have created a four-dimensional brain map that reveals how lesions similar to those seen in human MS form. These findings provide a window into the early disease state and could help identify potential targets for MS treatments and brain tissue repair. Thu, 27 Feb 2025 16:54:17 EST https://www.sciencedaily.com/releases/2025/02/250227165417.htm https://www.sciencedaily.com/releases/2025/02/250211134140.htm A new study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in eliciting damages to neurons that are most vulnerable in Huntington's disease and triggering downstream pathologies and motor impairment, shedding light on disease mechanisms and potential new ways to develop therapies. Tue, 11 Feb 2025 13:41:40 EST https://www.sciencedaily.com/releases/2025/02/250211134140.htm https://www.sciencedaily.com/releases/2025/01/250124191819.htm Researchers have found a promising drug candidate that could help restore vision in individuals with multiple sclerosis (MS) and other neurological conditions that damage neurons. Fri, 24 Jan 2025 19:18:19 EST https://www.sciencedaily.com/releases/2025/01/250124191819.htm https://www.sciencedaily.com/releases/2025/01/250124151345.htm A new study sheds light on one of the most severe consequences of stroke: damage to the brain's 'cables'-- the so-called nerve fibers -- which leads to permanent impairments. Fri, 24 Jan 2025 15:13:45 EST https://www.sciencedaily.com/releases/2025/01/250124151345.htm https://www.sciencedaily.com/releases/2025/01/250117112227.htm Subtle changes in the brain, detectable through advanced imaging, blood and spinal fluid analysis, happen approximately twenty years before a clinical motor diagnosis in people with Huntington's disease, finds a new study. Fri, 17 Jan 2025 11:22:27 EST https://www.sciencedaily.com/releases/2025/01/250117112227.htm https://www.sciencedaily.com/releases/2025/01/250116133442.htm Scientists have discovered a surprising mechanism by which the inherited genetic mutation known to cause Huntington's disease leads to the death of brain cells. The findings change the understanding of the fatal neurodegenerative disorder and suggest potential ways to delay or even prevent it. For 30 years, researchers have known that Huntington's is caused by an inherited mutation in the Huntingtin (HTT) gene, but they didn't know how the mutation causes brain cell death. A new study reveals that the inherited mutation doesn't itself harm cells. Rather, the mutation is innocuous for decades but slowly morphs into a highly toxic form that then quickly kills the cell. Thu, 16 Jan 2025 13:34:42 EST https://www.sciencedaily.com/releases/2025/01/250116133442.htm https://www.sciencedaily.com/releases/2025/01/250115165148.htm Researchers have described the neurodegeneration that occurs in the nervous system of the bowel in Batten disease, a rare and fatal genetic condition. In their latest study, a team showed that gene therapy to the bowel in mice modeling Batten disease reduced symptoms and extended lifespan. Wed, 15 Jan 2025 16:51:48 EST https://www.sciencedaily.com/releases/2025/01/250115165148.htm https://www.sciencedaily.com/releases/2025/01/250108143733.htm Unstable proteins are the main drivers of many different heritable diseases, according to a new study, including genetic disorders responsible for the formation of cataracts, and different types of rare neurological, developmental and muscle-wasting diseases. Unstable proteins are more likely to misfold and degrade, causing them to stop working or accumulate in harmful amounts inside cells. Wed, 08 Jan 2025 14:37:33 EST https://www.sciencedaily.com/releases/2025/01/250108143733.htm https://www.sciencedaily.com/releases/2024/12/241204113640.htm New research identifies an association between glyphosate exposure in mice and symptoms of neuroinflammation, as well as accelerated Alzheimer's disease-like pathology. This study tracks both the presence and impact of glyphosate's byproducts in the brain long after exposure ends, showing an array of persistent, damaging effects on brain health. The findings suggest the brain may be much more susceptible to the damaging effects of the herbicide than previously thought. Glyphosate is one of the most pervasive herbicides used in the U.S. and worldwide. Wed, 04 Dec 2024 11:36:40 EST https://www.sciencedaily.com/releases/2024/12/241204113640.htm https://www.sciencedaily.com/releases/2024/12/241203154345.htm Theta burst stimulation (TBS) is a non-invasive brain stimulation technique known for modifying human behavior and treating neurological diseases. A group of scientists conducted a systematic review and network meta-analysis to determine the effective TBS protocols for addressing schizophrenia symptoms and cognitive impairment. Their findings suggest that intermittent TBS over the left dorsolateral prefrontal cortex may offer a promising alternative to antipsychotic drug-based treatment. Tue, 03 Dec 2024 15:43:45 EST https://www.sciencedaily.com/releases/2024/12/241203154345.htm https://www.sciencedaily.com/releases/2024/11/241120121940.htm Researchers have led a clinical trial of a drug that mimics the effects of alcohol in more than 100 patients with laryngeal dystonia, a neurological condition that causes involuntary muscle spasms in the larynx and can have debilitating impacts on a person's voice. The trial was inspired by patient reports that their symptoms improved after consuming alcoholic beverages. Wed, 20 Nov 2024 12:19:40 EST https://www.sciencedaily.com/releases/2024/11/241120121940.htm https://www.sciencedaily.com/releases/2024/11/241113161027.htm The Huntington's disease (HD) mutation eventually causes a fatal brain disease in adulthood, but a new study finds that early in life, children with the HD mutation have bigger brains and higher IQ than children without the mutation. Wed, 13 Nov 2024 16:10:27 EST https://www.sciencedaily.com/releases/2024/11/241113161027.htm https://www.sciencedaily.com/releases/2024/11/241106132506.htm Why do mice have tails? The answer to this is not as simple as you might think. Research has shown that there's more to the humble mouse tail than previously assumed. Using a novel experimental setup involving a tilting platform, high-speed videography and mathematical modelling, scientists have demonstrated how mice swing their tails like a whip to maintain balance -- and these findings can help us better understand balance issues in humans, paving the way for spotting and treating neurodegenerative diseases like multiple sclerosis and Parkinson's disease at earlier stages. Wed, 06 Nov 2024 13:25:06 EST https://www.sciencedaily.com/releases/2024/11/241106132506.htm https://www.sciencedaily.com/releases/2024/10/241031151722.htm A team of doctors and scientists have identified the cause of a rare disorder involving intellectual disability and brain malformations. The team found a link between the child's neurological symptoms and a genetic change that affects how proteins are properly folded within cells, providing the parents with a molecular diagnosis and identifying an entirely new type of genetic disorder. Thu, 31 Oct 2024 15:17:22 EDT https://www.sciencedaily.com/releases/2024/10/241031151722.htm https://www.sciencedaily.com/releases/2024/10/241028131900.htm Researchers have identified a key biochemical mechanism relevant to the development of Huntington's Disease. This discovery opens up the possibility of studying the disease before its clinical onset and eventually stopping its progression. Mon, 28 Oct 2024 13:19:00 EDT https://www.sciencedaily.com/releases/2024/10/241028131900.htm https://www.sciencedaily.com/releases/2024/10/241024131817.htm Researchers describe how a gene called NANOG can improve the regrowth of damaged nerves after traumatic nerve injuries, like those sustained in motor vehicle accidents or gunshot wounds. Thu, 24 Oct 2024 13:18:17 EDT https://www.sciencedaily.com/releases/2024/10/241024131817.htm https://www.sciencedaily.com/releases/2024/10/241021123031.htm New research has revealed a connection between ancient viral DNA embedded in the human genome and the genetic risk for two major diseases that affect the central nervous system. Mon, 21 Oct 2024 12:30:31 EDT https://www.sciencedaily.com/releases/2024/10/241021123031.htm https://www.sciencedaily.com/releases/2024/09/240927173320.htm Researchers have made an important Huntington's disease discovery. They have found that the protein mutated in patients with Huntington's disease doesn't repair DNA as intended, impacting the ability of brain cells to heal themselves. Fri, 27 Sep 2024 17:33:20 EDT https://www.sciencedaily.com/releases/2024/09/240927173320.htm https://www.sciencedaily.com/releases/2024/09/240922232015.htm A new method for relocating proteins that have been misplaced in cells could mean new treatments for cancers and neurodegeneration. Sun, 22 Sep 2024 23:20:15 EDT https://www.sciencedaily.com/releases/2024/09/240922232015.htm https://www.sciencedaily.com/releases/2024/09/240913131127.htm Scientists have developed new potential therapies that selectively remove aggregated tau proteins, which are associated with Alzheimer's disease, and improve symptoms of neurodegeneration in mice. Fri, 13 Sep 2024 13:11:27 EDT https://www.sciencedaily.com/releases/2024/09/240913131127.htm https://www.sciencedaily.com/releases/2024/08/240822125933.htm Researchers have implicated a new gene in the progression of Huntington's disease in a brain organoid model. The gene may contribute to brain abnormalities much earlier than previously thought. Thu, 22 Aug 2024 12:59:33 EDT https://www.sciencedaily.com/releases/2024/08/240822125933.htm https://www.sciencedaily.com/releases/2024/08/240819130520.htm Two new studies are pointing the way toward round-the-clock personalized care for people with Parkinson's disease through an implanted device that can treat movement problems during the day and insomnia at night. Mon, 19 Aug 2024 13:05:20 EDT https://www.sciencedaily.com/releases/2024/08/240819130520.htm https://www.sciencedaily.com/releases/2024/08/240813131928.htm A new study has rewritten the conventionally understood evolutionary history of certain ion channels -- proteins critical for electrical signaling in the nervous system. The study shows that the Shaker family of ion channels were present in microscopic single cell organisms well before the common ancestor of all animals and thus before the origin of the nervous system. Tue, 13 Aug 2024 13:19:28 EDT https://www.sciencedaily.com/releases/2024/08/240813131928.htm https://www.sciencedaily.com/releases/2024/08/240809135936.htm Scientists report that gamma frequency light and sound stimulation preserves myelination in mouse models and reveal molecular mechanisms that may underlie the benefit. Fri, 09 Aug 2024 13:59:36 EDT https://www.sciencedaily.com/releases/2024/08/240809135936.htm https://www.sciencedaily.com/releases/2024/08/240805164413.htm Multiple sclerosis (MS) degrades the protective insulation around nerve cells, leaving their axons, which carry electrical impulses, exposed like bare wires. This can cause devastating problems with movement, balance and vision; and without treatment, it can lead to paralysis, loss of independence and a shortened lifespan. Mon, 05 Aug 2024 16:44:13 EDT https://www.sciencedaily.com/releases/2024/08/240805164413.htm https://www.sciencedaily.com/releases/2024/07/240726113357.htm The brain contains many cell types, from the prominent neurons to the lesser-known microglia. The latter are integral to the brain's immune system and play a crucial role as the brain's cleanup crew. A recent study highlights that microglia establish connections with neurons through tunneling nanotubes. The researchers observed that microglia utilize these tubes to facilitate the clearance of toxic proteins from neurons and to promote neuronal health. Fri, 26 Jul 2024 11:33:57 EDT https://www.sciencedaily.com/releases/2024/07/240726113357.htm https://www.sciencedaily.com/releases/2024/07/240704201424.htm New research details the connection between the neurological symptoms associated with aura and the migraine that follows. The study also identifies new proteins that could be responsible for headaches and may serve as foundation for new migraine drugs. Thu, 04 Jul 2024 20:14:24 EDT https://www.sciencedaily.com/releases/2024/07/240704201424.htm https://www.sciencedaily.com/releases/2024/07/240703183736.htm A recent study found that the way cerebellar neurons communicate with other brain regions is different in various movement disorders. Wed, 03 Jul 2024 18:37:36 EDT https://www.sciencedaily.com/releases/2024/07/240703183736.htm https://www.sciencedaily.com/releases/2024/07/240702135544.htm A class of proteins that regulates cell repair and enhances cell growth-signaling systems could be a promising new target for the treatment of Alzheimer's and other neurodegenerative diseases, according to a new study. They found that disrupting necessary sugar modifications of these proteins promotes cell repair and reverses cellular abnormalities that occur in neurodegenerative diseases. Tue, 02 Jul 2024 13:55:44 EDT https://www.sciencedaily.com/releases/2024/07/240702135544.htm https://www.sciencedaily.com/releases/2024/06/240605162418.htm Scientists have found that the process of adaptive myelination, which helps the brain learn new skills, can also promote addiction to opioids. Wed, 05 Jun 2024 16:24:18 EDT https://www.sciencedaily.com/releases/2024/06/240605162418.htm https://www.sciencedaily.com/releases/2024/06/240604132249.htm Deep brain stimulation (DBS) has shown promise as a treatment for some symptoms of Parkinson s disease (PD). However, not all symptoms improve equally well with DBS. A better understanding of how different sites of electrical stimulation impact the wide range of motor symptoms associated with PD could help fine-tune treatment. By studying PD patients at five different centers treated with DBS, investigators created an atlas that mapped four major symptoms of PD onto different regions of the brain. Based on these findings, the team created an algorithm capable of generating personalized, symptom-specific DBS treatment plans, which they preliminarily tested in five patients. Tue, 04 Jun 2024 13:22:49 EDT https://www.sciencedaily.com/releases/2024/06/240604132249.htm https://www.sciencedaily.com/releases/2024/05/240528174344.htm Researchers have demonstrated how B cells infected with the Epstein-Barr virus (EBV) can contribute to a pathogenic, inflammatory phenotype that contributes to multiple sclerosis (MS); the group has also shown how these problematic B cells can be selectively targeted in a way that reduces the damaging autoimmune response of multiple sclerosis. Tue, 28 May 2024 17:43:44 EDT https://www.sciencedaily.com/releases/2024/05/240528174344.htm https://www.sciencedaily.com/releases/2024/05/240520122802.htm Researchers have found that increased neuron formation and the subsequent rewiring of neural circuits in the hippocampus through exercise or genetic manipulation helps mice forget traumatic or drug-associated memories. The findings could offer a new approach to treating mental health conditions like post-traumatic stress disorder or drug addiction. Mon, 20 May 2024 12:28:02 EDT https://www.sciencedaily.com/releases/2024/05/240520122802.htm https://www.sciencedaily.com/releases/2024/05/240516160524.htm To date, approaches to treatments for Alzheimer's disease have not addressed the contribution of protein insolubility as a general phenomenon, instead focusing on one or two insoluble proteins. Researchers have recently completed a systematic study in worms that paints an intricate picture of the connections between insoluble proteins in neurodegenerative diseases and aging. Furthermore, the work demonstrated an intervention that could reverse the toxic effects of the aggregates by boosting mitochondrial health. Thu, 16 May 2024 16:05:24 EDT https://www.sciencedaily.com/releases/2024/05/240516160524.htm https://www.sciencedaily.com/releases/2024/05/240516160501.htm In an important step toward more effective gene therapies for brain diseases, researchers have engineered a gene-delivery vehicle that uses a human protein to efficiently cross the blood-brain barrier and deliver a disease-relevant gene to the brain in mice expressing the human protein. Because the vehicle binds to a well-studied protein in the blood-brain barrier, the scientists say it has a good chance at working in patients. Thu, 16 May 2024 16:05:01 EDT https://www.sciencedaily.com/releases/2024/05/240516160501.htm https://www.sciencedaily.com/releases/2024/05/240502141239.htm A breakthrough study appears to overcome difficulties that have long frustrated previous attempts to reverse a form of nerve damage that robs people with MS of motor control and gradually blunts cognitive functions for many people as they age. Thu, 02 May 2024 14:12:39 EDT https://www.sciencedaily.com/releases/2024/05/240502141239.htm https://www.sciencedaily.com/releases/2024/05/240502141226.htm Some neurological disorders can be improved through photobiomodulation, a non-invasive technique based on the application of low-intensity light to stimulate altered functions in specific regions of the body. Now, a study reveals how photobiomodulation applied to the brain-gut axis is effective in recovering some cognitive alterations and sequelae caused by chronic stress. The study opens up new perspectives for applying the technique in future therapies for the treatment of neurological diseases in patients. Thu, 02 May 2024 14:12:26 EDT https://www.sciencedaily.com/releases/2024/05/240502141226.htm https://www.sciencedaily.com/releases/2024/04/240430145616.htm Proteins are the workhorses of life. Organisms use them as building blocks, receptors, processors, couriers and catalysts. A protein's structure is critical to its function. Malformed proteins not only fail to carry out their tasks, they can accumulate and eventually gum up the inner workings of cells. As a result, misfolded proteins cause a variety of degenerative diseases, from Alzheimer's and Parkinson's to the blinding disease retinitis pigmentosa. These disorders are currently incurable. Tue, 30 Apr 2024 14:56:16 EDT https://www.sciencedaily.com/releases/2024/04/240430145616.htm https://www.sciencedaily.com/releases/2024/04/240425131549.htm A newly developed nanomaterial that mimics the behavior of proteins could be an effective tool for treating Alzheimer's and other neurodegenerative diseases. The nanomaterial alters the interaction between two key proteins in brain cells -- with a potentially powerful therapeutic effect. Thu, 25 Apr 2024 13:15:49 EDT https://www.sciencedaily.com/releases/2024/04/240425131549.htm https://www.sciencedaily.com/releases/2024/04/240403170920.htm Scientists have shown that treating mice with an antibody that blocks the interaction between APOE proteins (white) sprinkled within Alzheimer's disease plaques and the LILRB4 receptor on microglia cells (purple) activates them to clean up damaging plaques (blue) in the brain. Wed, 03 Apr 2024 17:09:20 EDT https://www.sciencedaily.com/releases/2024/04/240403170920.htm https://www.sciencedaily.com/releases/2024/03/240328111045.htm Familial Alzheimer's disease can be transferred via bone marrow transplant, researchers show. When the team transplanted bone marrow stem cells from mice carrying a hereditary version of Alzheimer's disease into normal lab mice, the recipients developed Alzheimer's disease -- and at an accelerated rate. Thu, 28 Mar 2024 11:10:45 EDT https://www.sciencedaily.com/releases/2024/03/240328111045.htm