https://www.sciencedaily.com/news/health_medicine/ovarian_cancer/ Information about ovarian cancer symptoms and treatments. Explore the latest medical research on ovarian cysts and ovarian cancer including including stages of the disease and new treatment options. en-us Wed, 11 Mar 2026 06:26:07 EDT Wed, 11 Mar 2026 06:26:07 EDT 60 https://www.sciencedaily.com/images/scidaily-logo-rss.png https://www.sciencedaily.com/news/health_medicine/ovarian_cancer/ For more science news, visit ScienceDaily. https://www.sciencedaily.com/releases/2026/02/260209064254.htm Scientists have discovered why ovarian cancer spreads so rapidly through the abdomen. Cancer cells enlist normally protective abdominal cells, forming mixed groups that work together to invade new tissue. These helper cells lead the way, allowing cancer to spread faster and resist chemotherapy. The findings uncover a critical weakness that future treatments may target. Mon, 09 Feb 2026 06:51:03 EST https://www.sciencedaily.com/releases/2026/02/260209064254.htm https://www.sciencedaily.com/releases/2026/02/260206012229.htm Colorectal cancer has long baffled scientists because, unlike most tumors, patients often do better when their cancers are packed with immune-suppressing regulatory T cells. New research finally explains why. Scientists discovered that these T cells aren’t all the same: one subtype actually helps keep tumors in check, while another shields cancer from immune attack. The balance between these “good” and “bad” cells can determine whether a tumor grows or shrinks. Fri, 06 Feb 2026 11:03:34 EST https://www.sciencedaily.com/releases/2026/02/260206012229.htm https://www.sciencedaily.com/releases/2026/01/260128075332.htm Scientists at Mount Sinai have unveiled a bold new way to fight metastatic cancer by turning the tumor’s own defenses against it. Instead of attacking cancer cells head-on, the experimental immunotherapy targets macrophages—immune cells that tumors hijack to shield themselves from attack. By eliminating or reprogramming these “bodyguards,” the treatment cracks open the tumor’s protective barrier and allows the immune system to flood in and destroy the cancer. Fri, 30 Jan 2026 01:05:29 EST https://www.sciencedaily.com/releases/2026/01/260128075332.htm https://www.sciencedaily.com/releases/2026/01/260127112124.htm A common parasite long thought to lie dormant is actually much more active and complex. Researchers found that Toxoplasma gondii cysts contain multiple parasite subtypes, not just one sleeping form. Some are primed to reactivate and cause disease, which helps explain why infections are so hard to treat. The discovery could reshape efforts to develop drugs that finally eliminate the parasite for good. Tue, 27 Jan 2026 23:11:20 EST https://www.sciencedaily.com/releases/2026/01/260127112124.htm https://www.sciencedaily.com/releases/2026/01/260118233553.htm A major new scientific review brings reassuring news for expectant parents: using acetaminophen, commonly known as Tylenol, during pregnancy does not increase a child’s risk of autism, ADHD, or intellectual disability. Researchers analyzed 43 high-quality studies, including powerful sibling comparisons that help separate medication effects from genetics and family environment. Earlier warnings appear to have been driven by underlying maternal health factors such as fever or pain rather than the medication itself. Mon, 19 Jan 2026 09:48:41 EST https://www.sciencedaily.com/releases/2026/01/260118233553.htm https://www.sciencedaily.com/releases/2025/12/251215025315.htm Scientists have discovered that key compounds from cannabis—CBD and THC—show surprisingly strong effects against ovarian cancer cells. Used together, they slow cell growth, reduce colony formation, and may even block the cancer’s ability to spread. Even more promising, the treatment caused minimal harm to healthy cells and appears to work by restoring a disrupted signaling pathway that fuels tumor growth. Mon, 15 Dec 2025 03:22:06 EST https://www.sciencedaily.com/releases/2025/12/251215025315.htm https://www.sciencedaily.com/releases/2025/11/251118220046.htm A specially engineered antibody that can infiltrate kidney cysts has shown the ability to block key growth signals driving polycystic kidney disease. Early mouse studies suggest it may halt or even reverse cyst expansion without harming healthy tissue. Wed, 19 Nov 2025 09:33:48 EST https://www.sciencedaily.com/releases/2025/11/251118220046.htm https://www.sciencedaily.com/releases/2025/09/250916221917.htm Rogue DNA rings known as ecDNA may hold the key to cracking glioblastoma’s deadly resilience. Emerging before tumors even form, they could offer scientists a crucial early-warning system and a chance to intervene before the disease becomes untreatable. Wed, 17 Sep 2025 21:33:46 EDT https://www.sciencedaily.com/releases/2025/09/250916221917.htm https://www.sciencedaily.com/releases/2025/08/250826081915.htm Knee osteoarthritis is a major cause of pain and disability, but routine X-rays often do more harm than good. New research shows that being shown an X-ray can increase anxiety, make people fear exercise, and lead them to believe surgery is the only option, even when less invasive treatments could help. By focusing on clinical diagnosis instead, patients may avoid unnecessary scans, reduce health costs, and make better choices about their care. Tue, 26 Aug 2025 09:27:09 EDT https://www.sciencedaily.com/releases/2025/08/250826081915.htm https://www.sciencedaily.com/releases/2025/08/250826005209.htm Painkillers we often trust — ibuprofen and acetaminophen — may be quietly accelerating one of the world’s greatest health crises: antibiotic resistance. Researchers discovered that these drugs not only fuel bacterial resistance on their own but make it far worse when combined with antibiotics. The findings are especially troubling for aged care settings, where residents commonly take multiple medications, creating perfect conditions for resistant bacteria to thrive. Tue, 26 Aug 2025 03:00:29 EDT https://www.sciencedaily.com/releases/2025/08/250826005209.htm https://www.sciencedaily.com/releases/2025/08/250803011826.htm Scientists have found a way to supercharge lung cancer treatment by transplanting healthy mitochondria into tumors, which both boosts immune response and makes chemotherapy far more effective. By combining this novel method with cisplatin, researchers reversed harmful tumor metabolism and empowered immune cells to fight back, all without added toxicity. Sun, 03 Aug 2025 04:12:15 EDT https://www.sciencedaily.com/releases/2025/08/250803011826.htm https://www.sciencedaily.com/releases/2025/07/250723045702.htm Radiation therapy, once thought of mainly as a local cancer treatment, is now showing power to awaken the immune system in surprising ways. Researchers discovered that combining radiation with immunotherapy can transform stubborn, unresponsive lung tumors into targets for immune attack—especially those considered “cold” and typically resistant. This happens through a rare and poorly understood effect where immune cells are activated systemically, not just at the radiation site. Patients whose tumors underwent this “warm-up” had significantly better outcomes, revealing a promising new strategy for fighting hard-to-treat cancers. Wed, 23 Jul 2025 09:33:19 EDT https://www.sciencedaily.com/releases/2025/07/250723045702.htm https://www.sciencedaily.com/releases/2025/06/250609060137.htm A breakthrough study from Keck Medicine of USC may have found a powerful new triple therapy for glioblastoma, one of the deadliest brain cancers. By combining Tumor Treating Fields (TTFields), which deliver electric waves into tumors, with immunotherapy and chemotherapy, researchers saw a major boost in survival. Mon, 09 Jun 2025 06:01:37 EDT https://www.sciencedaily.com/releases/2025/06/250609060137.htm https://www.sciencedaily.com/releases/2025/05/250527124537.htm A biobank for pediatric kidney tumors plays a key role in identifying hereditary causes of Wilms tumors. New insights gained with its help enable better risk assessment for affected families and could form the basis for targeted screening and improved early detection. Tue, 27 May 2025 12:45:37 EDT https://www.sciencedaily.com/releases/2025/05/250527124537.htm https://www.sciencedaily.com/releases/2025/05/250520224245.htm Scientists and medics have developed an ultra-rapid method of genetically diagnosing brain tumors that will cut the time it takes to classify them from 6-8 weeks, to as little as two hours.The team utilized the new approach during 50 brain tumor surgeries to deliver rapid, intraoperative diagnoses. This approach has achieved a 100% success rate, providing diagnostic results in under two hours from surgery and detailed tumor classifications within minutes of sequencing. Tue, 20 May 2025 22:42:45 EDT https://www.sciencedaily.com/releases/2025/05/250520224245.htm https://www.sciencedaily.com/releases/2025/04/250424165403.htm 'Cold' tumors are resistant to common immunotherapies. Researchers have uncovered a master regulator that can be manipulated to prevent tumor growth in mice. Thu, 24 Apr 2025 16:54:03 EDT https://www.sciencedaily.com/releases/2025/04/250424165403.htm https://www.sciencedaily.com/releases/2025/04/250423185925.htm Researchers have discovered that expansion of mutant blood cells, a phenomenon linked to aging, can be found in cancerous tumors, and this is associated with worse outcomes for patients. Wed, 23 Apr 2025 18:59:25 EDT https://www.sciencedaily.com/releases/2025/04/250423185925.htm https://www.sciencedaily.com/releases/2025/04/250421163229.htm An experimental drug now in clinical trials as a cancer treatment could help boost the power of first-line tuberculosis (TB) treatments by helping infected cells die a gentler death, investigators report. Mon, 21 Apr 2025 16:32:29 EDT https://www.sciencedaily.com/releases/2025/04/250421163229.htm https://www.sciencedaily.com/releases/2025/04/250418112803.htm Pancreatic cysts are fluid-filled sacs that can form in the pancreas. Some remain benign, while others have the potential to develop into pancreatic cancer. A recent study, which followed 257 patients in Japan for an average of five years, showed that the presence or absence of invasive nodules in pancreatic cysts is key to assessing whether these cysts are benign or cancerous. Fri, 18 Apr 2025 11:28:03 EDT https://www.sciencedaily.com/releases/2025/04/250418112803.htm https://www.sciencedaily.com/releases/2025/04/250410130742.htm Research has shed light on how a new type of antibody treatment reactivates patients' immune cells to fight ovarian cancer. Thu, 10 Apr 2025 13:07:42 EDT https://www.sciencedaily.com/releases/2025/04/250410130742.htm https://www.sciencedaily.com/releases/2025/04/250401131309.htm A team has developed a new way to quickly find personalized treatments for young cancer patients, by growing their tumors in chicken eggs and analyzing their proteins. The team has combined these two techniques to identify and test a drug for a young patient's tumor in time to be used for their treatment. Their success in finding a new drug for the patient shows how the study of proteins, known as proteomics, can be a valuable complement to the established study of genes (genomics) in real-time cancer therapies. Tue, 01 Apr 2025 13:13:09 EDT https://www.sciencedaily.com/releases/2025/04/250401131309.htm https://www.sciencedaily.com/releases/2025/03/250328112544.htm Researchers show that the immune system can recognize and control the latent stage of the parasite Toxoplasma gondii, a finding that can inform the study of latency in other infections of the nervous system. Fri, 28 Mar 2025 11:25:44 EDT https://www.sciencedaily.com/releases/2025/03/250328112544.htm https://www.sciencedaily.com/releases/2025/03/250313130948.htm A new type of antibody which stimulates the immune system to target cancer cells slows tumour growth, according to new research. Thu, 13 Mar 2025 13:09:48 EDT https://www.sciencedaily.com/releases/2025/03/250313130948.htm https://www.sciencedaily.com/releases/2025/02/250218113823.htm The immune systems of cancer patients are highly disrupted, with those who have a higher number of immune cells in their blood having a better survival rate, finds a new study that uses a pioneering technique. Tue, 18 Feb 2025 11:38:23 EST https://www.sciencedaily.com/releases/2025/02/250218113823.htm https://www.sciencedaily.com/releases/2025/02/250213144435.htm When a tumour develops, it creates a structure around itself called the tumour stroma, within which blood and lymphatic vessels ensure nutritional and respiratory biological exchanges. Lymphangiogenesis, i.e. the development of lymphatic vessels, is generally associated with a poor prognosis, as it favours the spread of metastases to other organs. By studying the cells that make up the wall of lymphatic vessels, a team has made an unexpected discovery: an enzyme they express appears to play a key role in supporting immune cells, particularly when they are activated by anti-tumor treatments. These results could pave the way for improving the effectiveness of immunotherapies. Thu, 13 Feb 2025 14:44:35 EST https://www.sciencedaily.com/releases/2025/02/250213144435.htm https://www.sciencedaily.com/releases/2025/02/250212134836.htm Gut bacteria are to blame for the failure of immune checkpoint therapy for ovarian cancer, new research reveals. Wed, 12 Feb 2025 13:48:36 EST https://www.sciencedaily.com/releases/2025/02/250212134836.htm https://www.sciencedaily.com/releases/2025/02/250212134500.htm Researchers have found that some particularly aggressive lung cancer cells can develop their own electric network, like that seen in the body's nervous system. Wed, 12 Feb 2025 13:45:00 EST https://www.sciencedaily.com/releases/2025/02/250212134500.htm https://www.sciencedaily.com/releases/2025/02/250211134138.htm Scientists have developed an innovative method for growing brain tumors of individual patients in the laboratory that mimic the original structure and the molecular property of the parental tumor as closely as possible. Drug tests in this model were found to correlate very well with actual patient responses, making it a valuable method for investigating therapies. Tue, 11 Feb 2025 13:41:38 EST https://www.sciencedaily.com/releases/2025/02/250211134138.htm https://www.sciencedaily.com/releases/2025/02/250210133016.htm Breast cancers at all stages are defined by the structure of their genomes, researchers find. Targeting these processes early is likely to offer unexpected therapeutic avenues. Mon, 10 Feb 2025 13:30:16 EST https://www.sciencedaily.com/releases/2025/02/250210133016.htm https://www.sciencedaily.com/releases/2025/02/250207122748.htm Pancreatic cancer patients may benefit from future precision treatments as a new study shows how some tumors may potentially be more susceptible to macrophage-based therapies, and clues behind why these tumors don't respond to existing immunotherapies. Fri, 07 Feb 2025 12:27:48 EST https://www.sciencedaily.com/releases/2025/02/250207122748.htm https://www.sciencedaily.com/releases/2025/02/250204132410.htm A research team has identified a critical event driving tumor growth in a type of medulloblastoma -- and a way to block it. Tue, 04 Feb 2025 13:24:10 EST https://www.sciencedaily.com/releases/2025/02/250204132410.htm https://www.sciencedaily.com/releases/2025/02/250203142732.htm It's a little pill with big responsibilities. But despite its primary role to prevent pregnancy, the contraceptive pill (or 'the Pill') could also help reduce the risk of ovarian cancer, according to new research. Mon, 03 Feb 2025 14:27:32 EST https://www.sciencedaily.com/releases/2025/02/250203142732.htm https://www.sciencedaily.com/releases/2025/01/250130172812.htm The most complex engineering of human cell lines ever has been achieved by scientists, revealing that our genomes are more resilient to significant structural changes than was previously thought. Thu, 30 Jan 2025 17:28:12 EST https://www.sciencedaily.com/releases/2025/01/250130172812.htm https://www.sciencedaily.com/releases/2025/01/250130161634.htm A mathematical modeling study suggests that ovarian cancer incidence could be reduced and healthcare savings boosted if women who have already completed their families were offered fallopian tube removal during any other suitable abdominal surgeries. Thu, 30 Jan 2025 16:16:34 EST https://www.sciencedaily.com/releases/2025/01/250130161634.htm https://www.sciencedaily.com/releases/2025/01/250127123901.htm Basal cell carcinomas, the most common form of skin cancer, occur in chronically sun-exposed areas such as the face. Locally advanced tumors in particular can be difficult to treat surgically. A research team has now investigated the effectiveness of a new type of therapy and achieved promising results: The active substance TVEC led to a reduction in the size of the basal cell carcinoma in all study participants, which not only improved surgical removal, but also led to a complete regression of the tumor in some of the patients. Mon, 27 Jan 2025 12:39:01 EST https://www.sciencedaily.com/releases/2025/01/250127123901.htm https://www.sciencedaily.com/releases/2025/01/250124151243.htm Successful test in breast cancer patients: the active agent digoxin, a cardiac medication, dissolves clusters of circulating breast cancer cells in the blood, thus reducing the risk of metastases formation. Fri, 24 Jan 2025 15:12:43 EST https://www.sciencedaily.com/releases/2025/01/250124151243.htm https://www.sciencedaily.com/releases/2025/01/250124151010.htm Researchers find blocking the KCNB2 gene can slow tumor growth, paving the way for next-gen treatments for childhood brain cancer. Fri, 24 Jan 2025 15:10:10 EST https://www.sciencedaily.com/releases/2025/01/250124151010.htm https://www.sciencedaily.com/releases/2025/01/250123110236.htm New research looked at how cancers arise in children who are predisposed to developing the childhood kidney cancer, Wilms tumor, which could help anticipate the development of tumors before they fully form. Thu, 23 Jan 2025 11:02:36 EST https://www.sciencedaily.com/releases/2025/01/250123110236.htm https://www.sciencedaily.com/releases/2025/01/250120113756.htm Researchers have determined how children's immune systems react to different kinds of cancer depending on their age. The study reveals significant differences between the immune response of children and adults, and has the potential to lead to new tailored treatments for children with cancer. Mon, 20 Jan 2025 11:37:56 EST https://www.sciencedaily.com/releases/2025/01/250120113756.htm https://www.sciencedaily.com/releases/2025/01/250116133431.htm Researchers have shown that the amount of a protein called CD74 can indicate which people with bowel cancer may respond best to immunotherapy. Thu, 16 Jan 2025 13:34:31 EST https://www.sciencedaily.com/releases/2025/01/250116133431.htm https://www.sciencedaily.com/releases/2025/01/250109223300.htm Tongue cancer (TC) cells can enter a chemo-resistant state by activating pathways related to autophagy and cholesterol synthesis, report researchers. Using a large-scale library of TC organoids they developed, the researchers performed comprehensive comparative analyses of chemo-sensitive and chemo-resistant cells. Their efforts shed light on promising avenues toward new treatments for tongue cancer. Thu, 09 Jan 2025 22:33:00 EST https://www.sciencedaily.com/releases/2025/01/250109223300.htm https://www.sciencedaily.com/releases/2025/01/250109125643.htm Researchers have shown that a test called ORACLE can predict lung cancer survival at the point of diagnosis better than currently used clinical risk factors. This could help doctors make more informed treatment decisions for people with stage 1 lung cancer, potentially reducing the risk of the cancer returning or spreading. Thu, 09 Jan 2025 12:56:43 EST https://www.sciencedaily.com/releases/2025/01/250109125643.htm https://www.sciencedaily.com/releases/2025/01/250108144420.htm A study has found targeting a protein called endocan and its related signaling pathway could be a promising new approach for treating glioblastoma, an aggressive and lethal type of brain cancer. Wed, 08 Jan 2025 14:44:20 EST https://www.sciencedaily.com/releases/2025/01/250108144420.htm https://www.sciencedaily.com/releases/2025/01/250103125032.htm Tumor cells circulating in the blood are the 'germ cells' of breast cancer metastases. They are very rare and could not be propagated in the culture dish until now, which made research into therapy resistance difficult. A team has now succeeded for the first time in cultivating stable tumor organoids directly from blood samples of breast cancer patients. Using these mini-tumors, the researchers were able to decipher a molecular signaling pathway that ensures the cancer cells' survival and resistance to therapy. With this knowledge, the team was able to develop an approach to specifically eliminate these tumor cells in lab experiments. Fri, 03 Jan 2025 12:50:32 EST https://www.sciencedaily.com/releases/2025/01/250103125032.htm https://www.sciencedaily.com/releases/2024/12/241220132857.htm Researchers have been able to identify at least three distinct subtypes of a rare type of bone cancer for the first time, which could transform clinical trials and patient care. Fri, 20 Dec 2024 13:28:57 EST https://www.sciencedaily.com/releases/2024/12/241220132857.htm https://www.sciencedaily.com/releases/2024/12/241217131240.htm Researchers have used a chemical compound to light up treatment-resistant cancers on imaging scans, in a breakthrough that could help medical professionals better target and treat cancer. Tue, 17 Dec 2024 13:12:40 EST https://www.sciencedaily.com/releases/2024/12/241217131240.htm https://www.sciencedaily.com/releases/2024/12/241216125729.htm Prostate cancer, especially in advanced stages such as castration-resistant prostate cancer, is challenging to treat. Traditional therapies targeting androgen receptor (AR) signaling have limited efficacy. In a recent study, researchers investigated the potential of azolato-bridged dinuclear platinum(II) complexes, particularly 5-H-Y, as promising alternatives. Their findings highlight the complex's ability to inhibit AR signaling and induce cell death in prostate cancer cells, providing a new avenue for prostate cancer treatment. Mon, 16 Dec 2024 12:57:29 EST https://www.sciencedaily.com/releases/2024/12/241216125729.htm https://www.sciencedaily.com/releases/2024/12/241213211332.htm An analysis of national data found that short-term mortality was not impacted for patients with advanced cancers during the shortage of the generic platinum chemotherapy drugs cisplatin and carboplatin that began in early 2023. Fri, 13 Dec 2024 21:13:32 EST https://www.sciencedaily.com/releases/2024/12/241213211332.htm https://www.sciencedaily.com/releases/2024/12/241209203736.htm A study sheds new light on how Toxoplasma gondii parasites make the proteins they need to enter a dormant stage that allows them to escape drug treatment. Mon, 09 Dec 2024 20:37:36 EST https://www.sciencedaily.com/releases/2024/12/241209203736.htm https://www.sciencedaily.com/releases/2024/12/241206002144.htm An MRI-based imaging technique predicts the response of ovarian cancer tumors to treatment, and rapidly reveals how well treatment is working, in patient-derived cell models. Fri, 06 Dec 2024 00:21:44 EST https://www.sciencedaily.com/releases/2024/12/241206002144.htm https://www.sciencedaily.com/releases/2024/12/241205143002.htm New research has found that women who have had both ovaries surgically removed before the age of 50 and carry a variant of the apolipoprotein gene, the APOE4 allele, are at high risk of late-life Alzheimer disease (AD). Use of hormone therapy mitigates this risk. Thu, 05 Dec 2024 14:30:02 EST https://www.sciencedaily.com/releases/2024/12/241205143002.htm https://www.sciencedaily.com/releases/2024/12/241205142901.htm A research team has developed a Mass Spectrometry technology-based technique to rapidly assess paracetamol levels from saliva. Thu, 05 Dec 2024 14:29:01 EST https://www.sciencedaily.com/releases/2024/12/241205142901.htm https://www.sciencedaily.com/releases/2024/12/241203194354.htm Today, women with estrogen-sensitive breast cancer receive anti-hormonal therapy. Researchers now show that postmenopausal women with low-risk tumors have a long-term benefit for at least 20 years, while the benefit was more short-term for younger women with similar tumor characteristics who had not yet gone through the menopause. Tue, 03 Dec 2024 19:43:54 EST https://www.sciencedaily.com/releases/2024/12/241203194354.htm https://www.sciencedaily.com/releases/2024/11/241127140246.htm Researchers have used a new gold-based drug to slow tumor growth in animals by 82% and target cancers more selectively than standard chemotherapy drugs, according to a new study. Wed, 27 Nov 2024 14:02:46 EST https://www.sciencedaily.com/releases/2024/11/241127140246.htm https://www.sciencedaily.com/releases/2024/11/241126135741.htm Cancer cells on the surface are thought to have natural advantages compared to cells deep within, which is why scientists have hypothesized tumors grow more in their periphery than in the core. A recent study found the opposite is true: tumors grow throughout their mass. The findings challenge the idea that a tumor is a 'two-speed' entity. Tue, 26 Nov 2024 13:57:41 EST https://www.sciencedaily.com/releases/2024/11/241126135741.htm https://www.sciencedaily.com/releases/2024/11/241114125646.htm Researchers have developed a three-dimensional mathematical model of prostate cancer. The model depicts various processes, including tumour growth, genetic evolution and tumour cell competition. Thu, 14 Nov 2024 12:56:46 EST https://www.sciencedaily.com/releases/2024/11/241114125646.htm https://www.sciencedaily.com/releases/2024/11/241108113735.htm Scientists investigated how an inherited genetic variation common among East Asians contributes to drug resistance in cancer cells, driving more aggressive cancer growth. The team trialled a precision therapy for this group by blocking the action of a protein called MCL-1, successfully killing many of the cancer cells in laboratory studies. Fri, 08 Nov 2024 11:37:35 EST https://www.sciencedaily.com/releases/2024/11/241108113735.htm https://www.sciencedaily.com/releases/2024/11/241104142208.htm Researchers have uncovered new targets that could be the key to effectively treating glioblastoma, a lethal type of brain cancer. These targets were identified through a screen for genetic vulnerabilities in patient-derived cancer stem cells that represent the variability found in tumors. Mon, 04 Nov 2024 14:22:08 EST https://www.sciencedaily.com/releases/2024/11/241104142208.htm https://www.sciencedaily.com/releases/2024/10/241030150316.htm Researchers have discovered a way that ovarian cancer tumors manipulate their environment to resist immunotherapy and identified a drug target that could overcome that resistance. The study used a cutting-edge spatial genomics technology and preclinical animal models, with tumor specimens from ovarian cancer patients further validating the findings. They found that ovarian cancer cells produce a molecule called Interleukin-4 (IL-4), which is typically associated with asthma and the skin condition eczema, also known as atopic dermatitis. The study went on to find that the cancer cells used IL-4 to create a protective environment that kept away killer immune cells, making the tumors resistant to immunotherapy. A drug, dupilumab, which blocks IL-4's activity, has been approved by the Food and Drug Administration (FDA) and is already used to treat asthma and eczema. This new study suggests dupilumab or similar drugs could be repurposed to enhance immunotherapy for ovarian cancer. Wed, 30 Oct 2024 15:03:16 EDT https://www.sciencedaily.com/releases/2024/10/241030150316.htm https://www.sciencedaily.com/releases/2024/10/241030145942.htm A new analysis has revealed detailed 3D maps of the internal structures of multiple tumor types. These cancer atlases reveal how different tumor cells -- and the cells of a tumor's surrounding environment -- are organized, in 3D, and how that organization changes when a tumor spreads to other organs. The detailed findings offer scientists valuable blueprints of tumors that could lead to new approaches to therapy and spark a new era in the field of cancer biology, according to the researchers. Wed, 30 Oct 2024 14:59:42 EDT https://www.sciencedaily.com/releases/2024/10/241030145942.htm