https://www.sciencedaily.com/news/health_medicine/joint_pain/ Information on causes of joint pains and how to find relief. Read latest research on early lupus symptoms and Lyme disease symptoms, and unravel the mystery behind the common aches and pains of fibromyalgia. en-us Fri, 16 Oct 2026 08:50:18 EDT Fri, 16 Oct 2026 08:50:18 EDT 60 https://www.sciencedaily.com/images/scidaily-logo-rss.png https://www.sciencedaily.com/news/health_medicine/joint_pain/ For more science news, visit ScienceDaily. https://www.sciencedaily.com/releases/2026/10/261015003550.htm Scientists have uncovered a hidden biological mechanism that helps explain how exercise can reverse some of the damage caused by muscle aging. The key is a gene called DEAF1, which becomes overactive with age and interferes with the muscles’ ability to clear damaged proteins and repair themselves. Exercise can help restore this balance, allowing older muscles to rebuild and regain strength, although the benefits may diminish when the system becomes too disrupted. Thu, 15 Oct 2026 20:41:45 EDT https://www.sciencedaily.com/releases/2026/10/261015003550.htm https://www.sciencedaily.com/releases/2026/10/261013234801.htm A promising new treatment for knee arthritis uses tiny, dissolvable particles to block abnormal blood vessels, easing inflammation and pain without joint replacement surgery. In a study of 194 patients, 80% experienced clinically meaningful pain relief lasting at least 12 months. Wed, 14 Oct 2026 00:39:11 EDT https://www.sciencedaily.com/releases/2026/10/261013234801.htm https://www.sciencedaily.com/releases/2026/10/261013015805.htm Ice baths, massages, compression garments, and recovery supplements promise faster muscle recovery, but research suggests their benefits are often overstated, and some techniques may even undermine long-term gains. Scientists say the most effective recovery methods are far simpler and cheaper: getting enough sleep, eating well, and giving muscles time to rebuild. Wed, 14 Oct 2026 08:04:20 EDT https://www.sciencedaily.com/releases/2026/10/261013015805.htm https://www.sciencedaily.com/releases/2026/10/261009025434.htm A surprisingly simple change in how you walk could help relieve knee arthritis pain and even slow joint damage. In a year-long clinical trial, researchers found that adjusting the angle of a person's foot while walking reduced osteoarthritis pain by an amount comparable to medication, without requiring drugs or surgery. Even more promising, MRI scans revealed that participants who adopted the personalized walking technique experienced slower deterioration in a marker of knee cartilage health. Sat, 10 Oct 2026 20:00:24 EDT https://www.sciencedaily.com/releases/2026/10/261009025434.htm https://www.sciencedaily.com/releases/2026/10/261007233348.htm A six-month study suggests that high-intensity interval training (HIIT) may offer older adults a powerful advantage: losing body fat while keeping their muscle. Unlike moderate-intensity workouts, which led to a small loss of lean muscle, HIIT preserved it while also improving body composition around the waist. Fri, 09 Oct 2026 06:57:40 EDT https://www.sciencedaily.com/releases/2026/10/261007233348.htm https://www.sciencedaily.com/releases/2026/10/261006234528.htm Researchers at Yale have identified a promising new approach to osteoarthritis that could do more than simply ease pain. The epilepsy drug lacosamide appears to block a protein involved in both pain signaling and cartilage destruction, helping damaged joints shift back toward repair in preclinical studies. Thu, 08 Oct 2026 09:52:56 EDT https://www.sciencedaily.com/releases/2026/10/261006234528.htm https://www.sciencedaily.com/releases/2026/10/261005011249.htm Scientists have found a surprising way to regrow damaged knee cartilage by blocking a protein that becomes more abundant with age. In old mice, the treatment restored naturally lost cartilage and also helped prevent osteoarthritis after ACL-like knee injuries, while human cartilage taken from knee replacement patients began producing new, functional joint cartilage after exposure to the same inhibitor. Tue, 06 Oct 2026 09:03:47 EDT https://www.sciencedaily.com/releases/2026/10/261005011249.htm https://www.sciencedaily.com/releases/2026/09/260930020317.htm Strength training may be one of the most powerful tools for staying independent as you age. Age related muscle loss, known as sarcopenia, can make everyday tasks harder while increasing the risk of falls, fractures, and loss of mobility. Research shows that resistance exercises such as squats, weights, resistance bands, and even body weight movements can preserve or rebuild strength, and surprisingly, even one session a week can produce meaningful benefits. Fri, 02 Oct 2026 05:36:45 EDT https://www.sciencedaily.com/releases/2026/09/260930020317.htm https://www.sciencedaily.com/releases/2026/09/260929053543.htm Scientists found that five seemingly unrelated conditions, including long Covid, ME/CFS, and PTSD, may disrupt many of the same biological networks involved in immunity, metabolism, and cellular energy. The findings could help explain their shared symptoms and may open the door to new blood tests and treatments. Thu, 01 Oct 2026 21:59:44 EDT https://www.sciencedaily.com/releases/2026/09/260929053543.htm https://www.sciencedaily.com/releases/2026/09/260925093208.htm Pain and fatigue in rheumatoid arthritis can persist even after inflammation improves, with depression, poor sleep, obesity, smoking, and chronic pain potentially helping sustain symptoms. Researchers say identifying these hidden drivers could prevent unnecessary medication changes and lead to more personalized treatment. Sun, 27 Sep 2026 06:49:13 EDT https://www.sciencedaily.com/releases/2026/09/260925093208.htm https://www.sciencedaily.com/releases/2026/09/260925093157.htm A compound the body can make after eating pomegranates, walnuts, and some berries improved measures of heart function by up to 80% in animal models of a difficult-to-treat form of heart failure. Urolithin A helped stiff heart tissue relax and reduced scarring and abnormal enlargement. It also improved relaxation in engineered human heart tissue. Mon, 28 Sep 2026 06:49:22 EDT https://www.sciencedaily.com/releases/2026/09/260925093157.htm https://www.sciencedaily.com/releases/2026/09/260923035924.htm A newly identified breakdown in communication between nerves and muscles could help explain why people lose strength as they age. Researchers were able to improve muscle strength in an animal model by targeting a key protein, raising hopes that some age-related weakness could eventually be treated. Thu, 24 Sep 2026 08:25:18 EDT https://www.sciencedaily.com/releases/2026/09/260923035924.htm https://www.sciencedaily.com/releases/2026/09/260914102452.htm Eating more ultra-processed foods was linked to greater fat buildup inside thigh muscles, according to MRI scans of 615 adults at risk for knee osteoarthritis. Surprisingly, the association remained even after researchers accounted for calorie intake, physical activity, and other factors. Fatty changes in these muscles may weaken support around the knee and potentially increase osteoarthritis risk. Tue, 15 Sep 2026 23:00:57 EDT https://www.sciencedaily.com/releases/2026/09/260914102452.htm https://www.sciencedaily.com/releases/2026/09/260911214306.htm Scientists have uncovered a natural braking system that helps the immune system switch off inflammation and prevent harmful immune cells from building up. Boosting this pathway in people reduced inflammation-related immune changes and sped up pain relief, pointing toward potential new treatments for chronic inflammatory diseases. Sat, 12 Sep 2026 21:44:05 EDT https://www.sciencedaily.com/releases/2026/09/260911214306.htm https://www.sciencedaily.com/releases/2026/09/260901070538.htm Scientists have found evidence that vulnerability to rheumatoid arthritis may begin before birth. Finger joints commonly affected by the disease develop with different tissue structures and larger populations of specialized fibroblasts than joints that are usually spared. Those cells also respond differently to inflammation, suggesting that the architecture of each joint may help determine where arthritis eventually takes hold. Sat, 05 Sep 2026 18:19:53 EDT https://www.sciencedaily.com/releases/2026/09/260901070538.htm https://www.sciencedaily.com/releases/2026/08/260828082330.htm CAR T-cell therapy dramatically reduced disease activity in six people with severe rheumatoid arthritis that had resisted other treatments, with three achieving medication-free remission. The treatment may work by clearing out harmful immune cells and effectively rebooting part of the immune system, although much larger studies are still needed. Sat, 29 Aug 2026 21:28:13 EDT https://www.sciencedaily.com/releases/2026/08/260828082330.htm https://www.sciencedaily.com/releases/2026/08/260820202904.htm Scientists have linked a specific gut bacterium, Roseburia inulinivorans, to stronger muscles in both humans and mice. Older adults who carried it had 29% greater handgrip strength, while treated mice gained about 30% more grip strength and developed larger, more fast-twitch muscle fibers. The bacterium was also less common in older people. Researchers say it could eventually become a probiotic candidate for helping combat age-related muscle loss. Fri, 21 Aug 2026 22:27:20 EDT https://www.sciencedaily.com/releases/2026/08/260820202904.htm https://www.sciencedaily.com/releases/2026/08/260814235852.htm Aging gradually wears down the cartilage and fluid that protect our joints, but avoiding movement may actually make matters worse. Exercise helps nourish cartilage, strengthens the muscles that protect joints, and can reduce osteoarthritis pain. Low-impact activities such as swimming, cycling, tai chi, yoga, and walking on varied terrain may also improve balance and mobility. Even a few minutes of the right kind of movement can make a difference. Sun, 16 Aug 2026 07:23:47 EDT https://www.sciencedaily.com/releases/2026/08/260814235852.htm https://www.sciencedaily.com/releases/2026/08/260808234959.htm Just a couple of hours of strength training each week could have surprisingly powerful effects on longevity. People who lifted weights for around 90 to 120 minutes weekly had a 13% lower risk of dying early, with especially large reductions in deaths from cardiovascular and neurological diseases. Pairing strength training with regular aerobic exercise was even more impressive, lowering overall death risk by about 45%. Sun, 09 Aug 2026 20:52:37 EDT https://www.sciencedaily.com/releases/2026/08/260808234959.htm https://www.sciencedaily.com/releases/2026/08/260801042814.htm A protein once thought to mainly protect chromosome ends may also be essential for keeping muscle stem cells ready to repair injuries. Researchers found that TRF2 helps these cells maintain their identity and coordinate the cycle of rest, repair, and renewal. Sun, 02 Aug 2026 09:23:34 EDT https://www.sciencedaily.com/releases/2026/08/260801042814.htm https://www.sciencedaily.com/releases/2026/07/260721000845.htm A plant-derived compound reduced swelling, inflammation, and joint damage in rats with rheumatoid arthritis. It also helped rebalance immune activity and improve the way certain fats were processed in the body. Researchers say the findings could lead to a new approach for treating the disease. Wed, 22 Jul 2026 21:57:05 EDT https://www.sciencedaily.com/releases/2026/07/260721000845.htm https://www.sciencedaily.com/releases/2026/06/260623014026.htm Researchers have uncovered a molecular “switch” that helps explain why exercise keeps aging muscles healthy. By reducing levels of a gene called DEAF1, physical activity allows older muscles to clear out damage, repair themselves, and maintain strength. Tue, 23 Jun 2026 01:40:26 EDT https://www.sciencedaily.com/releases/2026/06/260623014026.htm https://www.sciencedaily.com/releases/2026/06/260619101356.htm A Colorado research team has created experimental osteoarthritis treatments that appear to regenerate damaged joints rather than just relieve pain. In animal studies, a single injection restored arthritic joints to a healthy state within weeks, while a second therapy repaired cartilage and bone defects by harnessing the body’s own healing cells. Tue, 30 Jun 2026 15:40:21 EDT https://www.sciencedaily.com/releases/2026/06/260619101356.htm https://www.sciencedaily.com/releases/2026/06/260619033343.htm Compounds responsible for the aroma of cannabis and many other plants may offer a surprising new way to relieve chronic pain. Researchers found that several cannabis-derived terpenes significantly reduced pain in mouse models of fibromyalgia and post-surgical pain, with one terpene, geraniol, showing especially strong effects. Unlike THC, these compounds are not associated with psychoactive effects, making them a potentially attractive alternative for pain treatment. Sat, 20 Jun 2026 11:33:51 EDT https://www.sciencedaily.com/releases/2026/06/260619033343.htm https://www.sciencedaily.com/releases/2026/06/260612021604.htm A new treatment that blocks an aging-related protein restored lost cartilage in old mice and helped prevent arthritis after knee injuries. Human cartilage samples showed similar signs of regeneration, raising hopes for a future drug that could repair joints instead of replacing them. Fri, 12 Jun 2026 08:35:15 EDT https://www.sciencedaily.com/releases/2026/06/260612021604.htm https://www.sciencedaily.com/releases/2026/05/260530053426.htm A promising new study suggests rheumatoid arthritis may not be as inevitable as once thought for people at high risk. Researchers found that just one year of treatment with the immune-targeting drug abatacept delayed the onset of rheumatoid arthritis by up to four years, with benefits lasting long after treatment ended. Mon, 01 Jun 2026 09:25:47 EDT https://www.sciencedaily.com/releases/2026/05/260530053426.htm https://www.sciencedaily.com/releases/2026/05/260521072408.htm Researchers have discovered that the GLP-1 hormone targeted by drugs like Wegovy is present in very low amounts inside the joints of arthritis patients. That finding suggests high-dose GLP-1 medications could potentially reach the joints and influence inflammation directly, not just help through weight loss. Scientists say this could open the door to a completely new approach to arthritis treatment. Fri, 22 May 2026 02:12:43 EDT https://www.sciencedaily.com/releases/2026/05/260521072408.htm https://www.sciencedaily.com/releases/2026/03/260331001107.htm A surprising breakthrough suggests that a drug best known as Viagra could help treat a devastating childhood disease. Researchers found that sildenafil significantly improved symptoms in patients with Leigh syndrome—a rare and often fatal disorder that affects the brain and muscles. In a small study, patients showed stronger muscles, fewer seizures, and better recovery from dangerous metabolic crises, with some experiencing dramatic improvements in mobility and daily life. Tue, 31 Mar 2026 08:33:45 EDT https://www.sciencedaily.com/releases/2026/03/260331001107.htm https://www.sciencedaily.com/releases/2026/03/260308201620.htm Exercise normally boosts the body’s ability to use oxygen, a key marker of health and longevity — but high blood sugar can block that benefit. Researchers found that a ketogenic diet helped mice normalize blood sugar and dramatically improved how their muscles responded to exercise. Their muscles became better at using oxygen and built more endurance fibers. The results suggest diet and exercise may work together in surprising ways to improve metabolic health. Mon, 09 Mar 2026 18:24:51 EDT https://www.sciencedaily.com/releases/2026/03/260308201620.htm https://www.sciencedaily.com/releases/2026/03/260303145725.htm Stiff knees and aching hips may seem like an inevitable part of aging, but experts say we’re getting osteoarthritis all wrong. Despite affecting nearly 600 million people worldwide — and potentially a billion by 2050 — the most powerful treatment isn’t surgery or medication. It’s exercise. Movement nourishes cartilage, strengthens muscles, reduces inflammation, and even reshapes the biological processes driving joint damage. Wed, 04 Mar 2026 16:35:02 EST https://www.sciencedaily.com/releases/2026/03/260303145725.htm https://www.sciencedaily.com/releases/2026/02/260219040816.htm A new human study has uncovered how the body naturally turns off inflammation. Researchers found that fat-derived molecules called epoxy-oxylipins rein in immune cells that can otherwise drive chronic disease. Using a drug to boost these molecules reduced pain faster and lowered harmful inflammatory cells. The discovery could pave the way for safer treatments for arthritis, heart disease, and other inflammation-related conditions. Thu, 19 Feb 2026 10:16:55 EST https://www.sciencedaily.com/releases/2026/02/260219040816.htm https://www.sciencedaily.com/releases/2026/02/260204121549.htm Researchers have figured out how psoriasis can quietly turn into joint disease for some patients. Immune cells formed in inflamed skin can travel through the blood and reach the joints, where they sometimes trigger inflammation. The key difference lies in the joint’s ability to keep those cells in check. This insight could help doctors identify warning signs early and prevent lasting joint damage. Thu, 05 Feb 2026 10:44:32 EST https://www.sciencedaily.com/releases/2026/02/260204121549.htm https://www.sciencedaily.com/releases/2026/01/260127010144.htm A long-term study found that while a ketogenic diet prevented weight gain, it also triggered major metabolic problems. Mice developed fatty liver disease, abnormal blood fats, and an impaired ability to control blood sugar—especially after reintroducing carbohydrates. Male mice were hit hardest, showing severe liver damage. The results suggest keto’s benefits may come with hidden risks over time. Tue, 27 Jan 2026 08:24:34 EST https://www.sciencedaily.com/releases/2026/01/260127010144.htm https://www.sciencedaily.com/releases/2026/01/260120000333.htm Scientists at Stanford Medicine have discovered a treatment that can reverse cartilage loss in aging joints and even prevent arthritis after knee injuries. By blocking a protein linked to aging, the therapy restored healthy, shock-absorbing cartilage in old mice and injured joints, dramatically improving movement and joint function. Human cartilage samples from knee replacement surgeries also began regenerating when exposed to the treatment. Tue, 20 Jan 2026 23:55:09 EST https://www.sciencedaily.com/releases/2026/01/260120000333.htm https://www.sciencedaily.com/releases/2025/12/251214100940.htm Back pain is wrapped in persistent myths, but many are far from the truth. From misconceptions about heavy lifting and bed rest to confusion over posture, exercise, and surgery, Dr. Meghan Murphy breaks down what really causes pain and what actually helps. Her insights reveal that everyday habits, movement, and smart prevention often make a bigger difference than people realize. Mon, 15 Dec 2025 01:55:23 EST https://www.sciencedaily.com/releases/2025/12/251214100940.htm https://www.sciencedaily.com/releases/2025/11/251126095037.htm Rheumatoid arthritis begins years before pain ever appears, and scientists have now mapped the hidden immune battle that unfolds long before symptoms. By studying people with RA-linked antibodies over seven years, researchers discovered sweeping inflammation, malfunctioning immune cells, and even epigenetic reprogramming in cells that had never encountered a threat. These changes show that the body is preparing for autoimmune attack long before joints become damaged. Wed, 26 Nov 2025 13:01:04 EST https://www.sciencedaily.com/releases/2025/11/251126095037.htm https://www.sciencedaily.com/releases/2025/10/251021083638.htm New research reveals that exercise counteracts the mood-damaging effects of a Western-style diet through specific gut and hormonal mechanisms. Running restored metabolites tied to mental well-being and balanced key hormones like insulin and leptin. However, poor diet limited the brain’s ability to generate new neurons, showing diet still matters for full brain benefits. Tue, 21 Oct 2025 23:31:31 EDT https://www.sciencedaily.com/releases/2025/10/251021083638.htm https://www.sciencedaily.com/releases/2025/08/250826081915.htm Knee osteoarthritis is a major cause of pain and disability, but routine X-rays often do more harm than good. New research shows that being shown an X-ray can increase anxiety, make people fear exercise, and lead them to believe surgery is the only option, even when less invasive treatments could help. By focusing on clinical diagnosis instead, patients may avoid unnecessary scans, reduce health costs, and make better choices about their care. Tue, 26 Aug 2025 09:27:09 EDT https://www.sciencedaily.com/releases/2025/08/250826081915.htm https://www.sciencedaily.com/releases/2025/08/250809101024.htm Sunniva Kwapeng struggled with lipoedema, a painful condition causing disproportionate fat accumulation, until finally being diagnosed in her 40s. An NTNU study found that a low-carb diet helped alleviate pain and resulted in more weight loss than a low-fat diet. Though compression garments provided relief, the overall treatment options for this poorly understood condition remain scarce. Sun, 10 Aug 2025 01:57:45 EDT https://www.sciencedaily.com/releases/2025/08/250809101024.htm https://www.sciencedaily.com/releases/2025/08/250809100959.htm Ozempic’s weight loss benefits might come at the cost of muscle strength, even if muscle size remains relatively stable. This raises significant concerns for older adults, who are already at risk for muscle loss and reduced mobility. Researchers stress the urgent need for human clinical trials to understand these effects fully. Sun, 10 Aug 2025 02:15:51 EDT https://www.sciencedaily.com/releases/2025/08/250809100959.htm https://www.sciencedaily.com/releases/2025/08/250805041616.htm People eating minimally processed foods lost twice as much weight as those on ultra-processed diets, even though both diets were nutritionally balanced and participants could eat freely. This real-world, long-term study revealed that food processing itself—not just nutrients—plays a significant role in shaping body weight and health outcomes. Tue, 05 Aug 2025 10:14:49 EDT https://www.sciencedaily.com/releases/2025/08/250805041616.htm https://www.sciencedaily.com/releases/2025/07/250704032922.htm Scientists have discovered that the bacteria behind Lyme disease and anaplasmosis have a sneaky way of surviving inside ticks—they hijack the tick’s own cell functions to steal cholesterol they need to grow. By tapping into a built-in protein pathway, the bacteria keep themselves alive until they can infect a new host. The research opens the door to new methods of stopping these diseases before ticks ever get the chance to bite. A new web tool also reveals that this trick might be used by other blood-feeding bugs too. Fri, 04 Jul 2025 07:57:33 EDT https://www.sciencedaily.com/releases/2025/07/250704032922.htm https://www.sciencedaily.com/releases/2025/05/250514180735.htm Some patients with lupus who possess specific antibodies are at a higher risk of thrombotic events such as a blood clot, stroke or heart attack, a new study shows. The finding might help clinicians determine which patients may need early treatment and clinical monitoring for thrombotic events. Wed, 14 May 2025 18:07:35 EDT https://www.sciencedaily.com/releases/2025/05/250514180735.htm https://www.sciencedaily.com/releases/2025/05/250512165549.htm Researchers confirm and explore the role of estrogen-related receptors in regulating energy production in muscle cells during exercise. The findings indicate that developing a drug to boost estrogen-related receptors could be a powerful way to restore energy supplies in people with metabolic disorders, such as muscular dystrophy. Mon, 12 May 2025 16:55:49 EDT https://www.sciencedaily.com/releases/2025/05/250512165549.htm https://www.sciencedaily.com/releases/2025/04/250430142956.htm Just in time for tick season, new research is shining a light on how animals develop resistance to tick bites, which points toward the possibility of developing more effective vaccines against the tiny, disease-carrying bloodsuckers. Wed, 30 Apr 2025 14:29:56 EDT https://www.sciencedaily.com/releases/2025/04/250430142956.htm https://www.sciencedaily.com/releases/2025/04/250423164033.htm Piperacillin, an antibiotic in the same class as penicillin, effectively cured mice of Lyme disease at 100-times less than the effective dose of doxycycline, the current gold standard treatment. At such a low dose, piperacillin also had the added benefit of 'having virtually no impact on resident gut microbes.' Wed, 23 Apr 2025 16:40:33 EDT https://www.sciencedaily.com/releases/2025/04/250423164033.htm https://www.sciencedaily.com/releases/2025/04/250423164030.htm Scientists believe they know what causes the treated infection to mimic chronic illness: the body may be responding to remnants of the bacteria that causes Lyme that tend to pool in the liver and joint fluid. Wed, 23 Apr 2025 16:40:30 EDT https://www.sciencedaily.com/releases/2025/04/250423164030.htm https://www.sciencedaily.com/releases/2025/04/250421163231.htm A new study asked three questions about muscle protein synthesis in response to a nine-day diet and weight training regimen: First, does the source of protein -- plant or animal-based -- make any difference to muscle gain? Second, does it matter if total daily protein intake is evenly distributed throughout the day? And third, does a moderate but sufficient daily protein intake influence any of these variables? The answer to all three questions is 'no,' the researchers found. Mon, 21 Apr 2025 16:32:31 EDT https://www.sciencedaily.com/releases/2025/04/250421163231.htm https://www.sciencedaily.com/releases/2025/03/250326122932.htm A team has discovered a possible therapeutic approach to repair injured muscles either from aging or degenerative muscle disorders. Wed, 26 Mar 2025 12:29:32 EDT https://www.sciencedaily.com/releases/2025/03/250326122932.htm https://www.sciencedaily.com/releases/2025/03/250312165829.htm A recently completed study found that certain terpenes in Cannabis sativa are effective at relieving post-surgical and fibromyalgia pain in preclinical models. Wed, 12 Mar 2025 16:58:29 EDT https://www.sciencedaily.com/releases/2025/03/250312165829.htm https://www.sciencedaily.com/releases/2025/03/250312125003.htm Lupus is an autoimmune disease where the body's immune system attacks its own tissues and organs, causing inflammation and damaging organs. A new study has now shown that the natural active ingredient gluconolactone restores immune regulation, reduces inflammation and could enable targeted therapy with fewer side effects. Wed, 12 Mar 2025 12:50:03 EDT https://www.sciencedaily.com/releases/2025/03/250312125003.htm https://www.sciencedaily.com/releases/2025/03/250305134928.htm People with Crohn's disease and related joint inflammation linked to immune system dysfunction have distinct gut bacteria or microbiota, with the bacterium Mediterraneibacter gnavus being a potential biomarker, according to new study. Wed, 05 Mar 2025 13:49:28 EST https://www.sciencedaily.com/releases/2025/03/250305134928.htm https://www.sciencedaily.com/releases/2025/02/250227125107.htm Research reveals how a specific mutation in a protein called TRAF1 can shut down an overactive immune response, dramatically reducing inflammation in mice. This discovery could pave the way for a new class of drugs to treat rheumatoid arthritis, according to one of the authors. Using gene-editing technology, the researchers identified a critical mutation of a protein called TRAF1 and discovered that this mutation dramatically reduces inflammation by disrupting a critical molecular interaction that fuels the immune system into kicking into overdrive. Thu, 27 Feb 2025 12:51:07 EST https://www.sciencedaily.com/releases/2025/02/250227125107.htm https://www.sciencedaily.com/releases/2025/02/250226163244.htm A new study of more than 2,900 patients provides evidence that it's likely best to use as little corticosteroid medicine as possible when treating people who have lupus pericarditis, a common heart complication of the autoimmune disease Systemic Lupus Erythematosus (SLE). Wed, 26 Feb 2025 16:32:44 EST https://www.sciencedaily.com/releases/2025/02/250226163244.htm https://www.sciencedaily.com/releases/2025/02/250225201252.htm The efficient architecture of our joints, which allows our skeletons to be flexible and sturdy, originated among our most ancient jawed fish ancestors, according to a new study. Tue, 25 Feb 2025 20:12:52 EST https://www.sciencedaily.com/releases/2025/02/250225201252.htm https://www.sciencedaily.com/releases/2025/01/250129194603.htm Systemic lupus erythematosus commonly presents as a rash. The rashes are caused by inflammation from the immune system fighting the body. Wed, 29 Jan 2025 19:46:03 EST https://www.sciencedaily.com/releases/2025/01/250129194603.htm https://www.sciencedaily.com/releases/2025/01/250123163521.htm Drugs like Ozempic, Wegovy, and Mounjaro are changing how millions lose weight, but they come with a hidden drawback: they can strip away muscle along with fat, sometimes making up nearly half of the weight lost. Scientists at the Salk Institute may have found a solution in a little-known protein called BCL6, which helps muscles stay strong. In mouse studies, boosting BCL6 reversed muscle weakness and shrinkage, hinting at a future where weight-loss shots could be paired with a muscle-preserving therapy. Thu, 23 Jan 2025 16:35:21 EST https://www.sciencedaily.com/releases/2025/01/250123163521.htm https://www.sciencedaily.com/releases/2025/01/250119230805.htm People with pockets of fat hidden inside their muscles are at a higher risk of dying or being hospitalized from a heart attack or heart failure, regardless of their body mass index, according to new research. This 'intermuscular' fat is highly prized in beef steaks for cooking. However, little is known about this type of body fat in humans, and its impact on health. This is the first study to comprehensively investigate the effects of fatty muscles on heart disease. The new finding adds evidence that existing measures, such as body mass index or waist circumference, are not adequate to evaluate the risk of heart disease accurately for all people. Sun, 19 Jan 2025 23:08:05 EST https://www.sciencedaily.com/releases/2025/01/250119230805.htm https://www.sciencedaily.com/releases/2025/01/250117161232.htm Across most of the Northeast, getting bitten by a blacklegged tick-- also called a deer tick -- is a risk during spring, summer, and fall. A new Dartmouth study, published in Parasites and Vectors, finds that 50% of adult blacklegged ticks carry the bacteria that causes Lyme disease while 20% to 25% of the younger (nymph) blacklegged ticks carry the bacteria. Fri, 17 Jan 2025 16:12:32 EST https://www.sciencedaily.com/releases/2025/01/250117161232.htm https://www.sciencedaily.com/releases/2024/12/241209163205.htm Studying the cells of people and genetically engineered mice, scientists say they have uncovered a potential reason why patients with Loeys-Dietz syndrome, an inherited connective tissue disorder, are especially prone to developing aneurysms at the root of the aorta. Mon, 09 Dec 2024 16:32:05 EST https://www.sciencedaily.com/releases/2024/12/241209163205.htm