https://www.sciencedaily.com/news/health_medicine/crohn's_disease/ Crohn's disease. Read the latest research on Crohn's disease: risk factors, reducing flare ups, and new treatment options. en-us Tue, 10 Mar 2026 06:55:24 EDT Tue, 10 Mar 2026 06:55:24 EDT 60 https://www.sciencedaily.com/images/scidaily-logo-rss.png https://www.sciencedaily.com/news/health_medicine/crohn's_disease/ For more science news, visit ScienceDaily. https://www.sciencedaily.com/releases/2026/03/260303145733.htm Daily aspirin does not reliably prevent bowel cancer in people at average risk, according to a major new review. Any potential protective effect may take more than a decade to appear — if it appears at all — and the evidence for that benefit is weak. In contrast, the risk of serious bleeding begins right away, even with low-dose aspirin. Experts warn that prevention decisions should be individualized, not automatic. Wed, 04 Mar 2026 18:12:30 EST https://www.sciencedaily.com/releases/2026/03/260303145733.htm https://www.sciencedaily.com/releases/2026/02/260219040816.htm A new human study has uncovered how the body naturally turns off inflammation. Researchers found that fat-derived molecules called epoxy-oxylipins rein in immune cells that can otherwise drive chronic disease. Using a drug to boost these molecules reduced pain faster and lowered harmful inflammatory cells. The discovery could pave the way for safer treatments for arthritis, heart disease, and other inflammation-related conditions. Thu, 19 Feb 2026 10:16:55 EST https://www.sciencedaily.com/releases/2026/02/260219040816.htm https://www.sciencedaily.com/releases/2026/02/260211204210.htm A global study has uncovered a mysterious group of gut bacteria that shows up again and again in healthy people. Known as CAG-170, these microbes were found at lower levels in people with a range of chronic diseases. Genetic clues suggest they help digest food and support the broader gut ecosystem. Researchers say the discovery could reshape how we measure and maintain gut health. Sat, 14 Feb 2026 07:58:31 EST https://www.sciencedaily.com/releases/2026/02/260211204210.htm https://www.sciencedaily.com/releases/2026/02/260211204204.htm A new clinical trial suggests that changing when you eat could make a meaningful difference for people living with Crohn’s disease. Researchers found that time-restricted feeding, a form of intermittent fasting that limits meals to an 8-hour daily window, reduced disease activity by 40% and cut abdominal discomfort in half over 12 weeks. Participants also lost weight and showed healthier inflammation and immune markers, even though they did not reduce calories or change what they ate. Wed, 11 Feb 2026 21:25:28 EST https://www.sciencedaily.com/releases/2026/02/260211204204.htm https://www.sciencedaily.com/releases/2026/01/260125083401.htm A newly uncovered immune chain reaction in the gut may explain why people with inflammatory bowel disease face a much higher risk of colorectal cancer. Researchers found that a powerful inflammatory signal flips on specialized gut immune cells, which then call in waves of white blood cells from the bone marrow and rewire them in ways that help tumors grow. This process appears to damage DNA in the gut lining and create a tumor-friendly environment. Sun, 25 Jan 2026 10:15:11 EST https://www.sciencedaily.com/releases/2026/01/260125083401.htm https://www.sciencedaily.com/releases/2026/01/260124003851.htm Chronic inflammation may be quietly reshaping the colon and making it more vulnerable to early-onset colorectal cancer. Scientists found that colon tissue in younger patients was stiffer, even in areas that appeared healthy, suggesting these changes may happen before cancer develops. Lab experiments showed that cancer cells grow faster in rigid environments. Sat, 24 Jan 2026 10:48:02 EST https://www.sciencedaily.com/releases/2026/01/260124003851.htm https://www.sciencedaily.com/releases/2026/01/260122093437.htm A new blood test may reveal Crohn’s disease years before symptoms begin. The test detects an unusual immune response to gut bacteria in people who later develop the condition. By studying healthy relatives of Crohn’s patients, researchers identified early warning signals long in advance. The findings raise hope for earlier diagnosis and future prevention. Thu, 22 Jan 2026 09:34:37 EST https://www.sciencedaily.com/releases/2026/01/260122093437.htm https://www.sciencedaily.com/releases/2026/01/260122074659.htm Scientists studying genetic data from over a quarter million people have uncovered new clues about what controls how fast the gut moves. They identified multiple DNA regions linked to bowel movement frequency, confirming known gut pathways and revealing new ones. The biggest surprise was a strong connection to vitamin B1, a common nutrient not usually linked to digestion. Thu, 22 Jan 2026 07:53:07 EST https://www.sciencedaily.com/releases/2026/01/260122074659.htm https://www.sciencedaily.com/releases/2026/01/260120000323.htm Ibuprofen may be doing more than easing aches and pains—it could also help reduce the risk of some cancers. Studies have linked regular use to lower rates of endometrial and bowel cancer, likely because the drug dampens inflammation that fuels tumor growth. Researchers have even found it can interfere with genes cancer cells rely on to survive. Still, experts warn that long-term use carries risks and shouldn’t replace proven prevention strategies. Tue, 20 Jan 2026 03:47:11 EST https://www.sciencedaily.com/releases/2026/01/260120000323.htm https://www.sciencedaily.com/releases/2026/01/260108231411.htm Although the gut renews itself constantly, its stem cells accumulate age-related molecular changes that quietly alter how genes are switched on and off. Scientists found that this “epigenetic drift” follows a clear pattern and appears in both aging intestines and most colon cancers. Some regions age faster than others, forming a patchwork of weakened tissue more prone to degeneration. Encouragingly, researchers showed this drift can be slowed—and partly reversed—by restoring iron levels or key cellular signals. Sat, 10 Jan 2026 08:17:12 EST https://www.sciencedaily.com/releases/2026/01/260108231411.htm https://www.sciencedaily.com/releases/2026/01/260107225535.htm A brief, intense workout may do more than boost fitness—it could help fight cancer. Researchers found that just 10 minutes of hard exercise releases molecules into the bloodstream that switch on DNA repair and shut down cancer growth signals. When these molecules were applied to bowel cancer cells, hundreds of cancer-related genes changed activity. The discovery helps explain how exercise lowers cancer risk and hints at future therapies inspired by movement. Thu, 08 Jan 2026 04:14:06 EST https://www.sciencedaily.com/releases/2026/01/260107225535.htm https://www.sciencedaily.com/releases/2026/01/260107225532.htm Long COVID affects an estimated 65 million people worldwide and can damage the brain, heart, blood vessels, and immune system long after infection. Researchers now link symptoms to lingering virus, inflammation, micro-clots, and disrupted energy metabolism. While structured rehab and pacing can improve quality of life, a growing list of experimental treatments—from antivirals and metformin to microbiome therapies and biologics—shows early promise. Clear answers, however, are still limited by small studies and the lack of large, definitive trials. Thu, 08 Jan 2026 19:57:41 EST https://www.sciencedaily.com/releases/2026/01/260107225532.htm https://www.sciencedaily.com/releases/2026/01/260103155028.htm Researchers have discovered a way to help aging intestines heal themselves using CAR T-cell therapy. By targeting senescent cells that build up over time, the treatment boosted gut regeneration, reduced inflammation, and improved nutrient absorption in mice. It even helped protect the intestine from radiation damage, with benefits lasting up to a year. Early results in human intestinal cells suggest the approach could one day improve gut health in older adults and cancer patients. Sat, 03 Jan 2026 20:59:17 EST https://www.sciencedaily.com/releases/2026/01/260103155028.htm https://www.sciencedaily.com/releases/2025/12/251227082716.htm Stanford scientists have uncovered how mRNA COVID-19 vaccines can very rarely trigger heart inflammation in young men — and how that risk might be reduced. They found that the vaccines can spark a two-step immune reaction that floods the body with inflammatory signals, drawing aggressive immune cells into the heart and causing temporary injury. Sat, 27 Dec 2025 10:52:27 EST https://www.sciencedaily.com/releases/2025/12/251227082716.htm https://www.sciencedaily.com/releases/2025/12/251225031249.htm Dry eye disease affects millions of people, causing burning, redness, and constant eye fatigue that can worsen over time. Scientists now believe the problem may begin deep inside tear glands, where a vital cellular cleanup process fails to function properly. By growing miniature human tear glands from stem cells, researchers were able to watch what happens when this system breaks down, leading to fewer protective tears and increased cell damage. Fri, 02 Jan 2026 11:17:56 EST https://www.sciencedaily.com/releases/2025/12/251225031249.htm https://www.sciencedaily.com/releases/2025/12/251217082457.htm A rare tick-borne allergy linked to red meat has now been confirmed as deadly for the first time. A healthy New Jersey man collapsed and died hours after eating beef, with later testing revealing a severe allergic reaction tied to alpha-gal, a sugar spread by Lone Star tick bites. Symptoms often appear hours later, making the condition easy to miss. Researchers warn that growing tick populations could put more people at risk. Wed, 17 Dec 2025 08:24:57 EST https://www.sciencedaily.com/releases/2025/12/251217082457.htm https://www.sciencedaily.com/releases/2025/11/251126095023.htm Spermine, a small but powerful molecule in the body, helps neutralize harmful protein accumulations linked to Alzheimer’s and Parkinson’s. It encourages these misfolded proteins to gather into manageable clumps that cells can more efficiently dispose of through autophagy. Experiments in nematodes show that spermine also enhances longevity and cellular energy production. These insights open the door to targeted therapies powered by polyamines and advanced AI-driven molecular design. Thu, 27 Nov 2025 07:35:52 EST https://www.sciencedaily.com/releases/2025/11/251126095023.htm https://www.sciencedaily.com/releases/2025/11/251121090729.htm Researchers discovered that chemotherapy can accidentally trigger a stress alarm in immune cells, causing inflammation that damages nerves. Blocking this alarm protected mice from nerve pain and kept their nerves healthier. A drug already being tested for cancer may help do the same in people. Early blood tests suggest it may even be possible to predict who will develop these symptoms before they happen. Fri, 21 Nov 2025 11:02:54 EST https://www.sciencedaily.com/releases/2025/11/251121090729.htm https://www.sciencedaily.com/releases/2025/11/251121082046.htm Tiny ingestible spheres filled with engineered bacteria can detect intestinal bleeding by glowing when they encounter heme. Early tests in mice suggest they could become a quick, noninvasive way to monitor gut disease. Fri, 21 Nov 2025 08:30:39 EST https://www.sciencedaily.com/releases/2025/11/251121082046.htm https://www.sciencedaily.com/releases/2025/11/251118220049.htm Researchers discovered that chronic inflammation fundamentally remodels the bone marrow, allowing mutated stem cell clones to quietly gain dominance with age. Reprogrammed stromal cells and interferon-responsive T cells create a self-sustaining inflammatory loop that weakens blood production. Surprisingly, the mutant cells themselves may not be the main instigators. Tue, 18 Nov 2025 22:00:49 EST https://www.sciencedaily.com/releases/2025/11/251118220049.htm https://www.sciencedaily.com/releases/2025/11/251118220041.htm Scientists are uncovering how GLP-1 drugs like Ozempic and Wegovy act on brain regions that control hunger, nausea, pleasure-based eating, and thirst. These discoveries may help create treatments that keep the benefits of weight loss while reducing unwanted side effects. Tue, 18 Nov 2025 22:48:02 EST https://www.sciencedaily.com/releases/2025/11/251118220041.htm https://www.sciencedaily.com/releases/2025/11/251117095639.htm Chronic pain might quietly push people toward developing high blood pressure—and the more widespread the pain, the greater the danger. A massive analysis of over 200,000 adults uncovered strong links between long-lasting pain, depression, inflammation, and rising hypertension risk. Mon, 17 Nov 2025 22:42:19 EST https://www.sciencedaily.com/releases/2025/11/251117095639.htm https://www.sciencedaily.com/releases/2025/11/251111010008.htm Texas A&M scientists have unlocked new potential for astatine-211, a rare and short-lived element, as a highly precise cancer-fighting isotope. Its alpha emissions destroy tumor cells while sparing healthy tissue, making it ideal for targeted therapy. Tue, 11 Nov 2025 13:20:37 EST https://www.sciencedaily.com/releases/2025/11/251111010008.htm https://www.sciencedaily.com/releases/2025/11/251107010250.htm Scientists have pinpointed a “Big Bang” moment in bowel cancer—when cells first evade the immune system. This early immune escape locks in how the cancer will behave as it grows. The discovery could help predict which patients respond to immunotherapy and lead to new vaccine strategies Fri, 07 Nov 2025 05:13:22 EST https://www.sciencedaily.com/releases/2025/11/251107010250.htm https://www.sciencedaily.com/releases/2025/11/251103093012.htm UC San Diego researchers combined artificial intelligence with molecular biology to unravel how immune cells in the gut decide between inflammation and healing, a process gone awry in Crohn’s disease. They discovered that the NOD2 gene’s interaction with a protein called girdin is crucial for maintaining balance. When this connection is lost due to a common mutation, inflammation spirals out of control. Mon, 03 Nov 2025 21:44:57 EST https://www.sciencedaily.com/releases/2025/11/251103093012.htm https://www.sciencedaily.com/releases/2025/11/251101000713.htm Researchers discovered that altering the body’s natural rhythm can help protect the brain from Alzheimer’s damage. By turning off a circadian protein in mice, they raised NAD+ levels and reduced harmful tau buildup. The findings suggest that adjusting the body’s clock may one day help prevent neurodegeneration. Sat, 01 Nov 2025 09:20:45 EDT https://www.sciencedaily.com/releases/2025/11/251101000713.htm https://www.sciencedaily.com/releases/2025/10/251025084601.htm Researchers found that combining regular exercise with omega-3 supplements can make a big difference for oral health. The duo helps the immune system fight off chronic tooth root infections and reduces bone loss around the teeth. In animal studies, those that both exercised and took omega-3s had much lower inflammation and healthier bone structure. Sun, 26 Oct 2025 02:16:05 EDT https://www.sciencedaily.com/releases/2025/10/251025084601.htm https://www.sciencedaily.com/releases/2025/10/251023031625.htm MIT scientists have found that an amino acid called cysteine can help the gut heal itself. In mouse studies, a cysteine-rich diet activated immune cells that release a molecule speeding up tissue repair in the small intestine. This process helped regenerate the gut lining after damage from radiation or chemotherapy. Thu, 23 Oct 2025 09:10:35 EDT https://www.sciencedaily.com/releases/2025/10/251023031625.htm https://www.sciencedaily.com/releases/2025/10/251014014421.htm Endurance exercise may train the immune system as much as the muscles. Older adults with decades of running or cycling had immune cells that functioned better and aged more slowly. Their inflammation levels were lower and their cells resisted fatigue even under stress. The findings point to a direct link between lifelong fitness and healthier immune regulation. Tue, 14 Oct 2025 23:27:02 EDT https://www.sciencedaily.com/releases/2025/10/251014014421.htm https://www.sciencedaily.com/releases/2025/10/251008030949.htm Researchers have designed a peptide that prevents the deadly misfolding of alpha-synuclein, the protein behind Parkinson’s and some dementias. In lab and animal tests, it stabilized the protein and improved motor function. The work demonstrates the power of rational drug design in tackling brain diseases that have long lacked effective treatments. Wed, 08 Oct 2025 03:09:49 EDT https://www.sciencedaily.com/releases/2025/10/251008030949.htm https://www.sciencedaily.com/releases/2025/09/250929054923.htm Morning sickness isn’t just random misery—it’s a biological defense system shaped by evolution to protect the fetus. By linking immune responses to nausea and food aversions, UCLA researchers show these symptoms are signs of a healthy pregnancy. Mon, 29 Sep 2025 22:50:17 EDT https://www.sciencedaily.com/releases/2025/09/250929054923.htm https://www.sciencedaily.com/releases/2025/09/250927031221.htm Daily cocoa extract supplements reduced key inflammation markers in older adults, pointing to a role in protecting the heart. The findings reinforce the value of flavanol-rich, plant-based foods for healthier aging. Sat, 27 Sep 2025 12:21:54 EDT https://www.sciencedaily.com/releases/2025/09/250927031221.htm https://www.sciencedaily.com/releases/2025/09/250926035030.htm Scientists have discovered a way to block pain while still allowing the body’s natural healing to take place. Current painkillers like ibuprofen and aspirin often come with harmful side effects because they shut down both pain and inflammation. But this new research identified a single “pain switch” receptor that can be turned off without interfering with inflammation, which actually helps the body recover. Fri, 26 Sep 2025 19:56:30 EDT https://www.sciencedaily.com/releases/2025/09/250926035030.htm https://www.sciencedaily.com/releases/2025/09/250922074954.htm Researchers found that pancreatic pre-cancer cells mimic dementia by forming clumps of proteins due to faulty recycling processes. These insights could shed light on why pancreatic cancer develops so aggressively and why it is difficult to treat. By studying overlaps with neurological diseases, scientists hope to identify new strategies for prevention and treatment. Mon, 22 Sep 2025 23:30:44 EDT https://www.sciencedaily.com/releases/2025/09/250922074954.htm https://www.sciencedaily.com/releases/2025/09/250920214455.htm Duke University scientists have discovered that pancreatic alpha cells, long believed to only produce glucagon, actually generate powerful amounts of GLP-1 — the same hormone mimicked by popular diabetes drugs like semaglutide (Ozempic and Wegovy). Even more surprisingly, when glucagon production is blocked, alpha cells “switch gears” and boost GLP-1 output, enhancing insulin release and blood sugar control. Sun, 21 Sep 2025 08:45:57 EDT https://www.sciencedaily.com/releases/2025/09/250920214455.htm https://www.sciencedaily.com/releases/2025/09/250919085235.htm For decades, scientists have puzzled over why smoking makes Crohn’s disease worse but seems to protect people from ulcerative colitis. Now, researchers at RIKEN have discovered that smoking creates metabolites like hydroquinone that allow mouth bacteria—especially Streptococcus mitis—to settle in the gut. These bacteria spark an immune response that reduces inflammation in colitis but worsens Crohn’s. The findings open the door to new therapies using probiotics or targeted compounds that mimic smoking’s protective effects without its deadly risks. Fri, 19 Sep 2025 20:28:11 EDT https://www.sciencedaily.com/releases/2025/09/250919085235.htm https://www.sciencedaily.com/releases/2025/09/250901104649.htm Japanese scientists have developed ADRIANA, a non-opioid painkiller that could provide powerful relief without the dangers of addiction. With successful trials already completed, large U.S. studies are now underway, raising hopes for a safer future in pain treatment. Tue, 02 Sep 2025 03:32:58 EDT https://www.sciencedaily.com/releases/2025/09/250901104649.htm https://www.sciencedaily.com/releases/2025/07/250730030346.htm A new global study reveals a striking post-pandemic surge in gut-brain disorders like IBS and functional dyspepsia. Researchers compared data from 2017 and 2023 and discovered sharp increases IBS up 28% and dyspepsia nearly 44%. Those suffering from long COVID were especially vulnerable, reporting more anxiety, depression, and worse quality of life. These findings spotlight the urgent need for deeper investigation into the gut-brain axis and revised care models in a post-COVID world. Wed, 30 Jul 2025 03:03:46 EDT https://www.sciencedaily.com/releases/2025/07/250730030346.htm https://www.sciencedaily.com/releases/2025/07/250729001208.htm A mysterious gut hormone may be behind many cases of chronic diarrhea, especially in people with undiagnosed bile acid malabsorption, a condition often mistaken for irritable bowel syndrome. Researchers from the University of Cambridge identified that the hormone INSL5 spikes when bile acid reaches the colon, triggering intense diarrhea. Their discovery not only sheds light on the biological cause of symptoms but opens the door to a diagnostic blood test and new treatment options, including a surprising existing drug that blocks this hormone’s effects. Tue, 29 Jul 2025 01:33:52 EDT https://www.sciencedaily.com/releases/2025/07/250729001208.htm https://www.sciencedaily.com/releases/2025/06/250627021847.htm Misbehaving T cells light up long before Parkinson’s symptoms show, zeroing in on vulnerable brain proteins. Their early surge could double as an alarm bell and a target for stop-it-early treatments. Fri, 27 Jun 2025 05:49:32 EDT https://www.sciencedaily.com/releases/2025/06/250627021847.htm https://www.sciencedaily.com/releases/2025/06/250624044330.htm Major depressive disorder affects hundreds of millions worldwide, but a key to understanding its origins may lie in the brain’s immune system. New findings spotlight astrocytes—previously overshadowed by microglia—as major players in neuroinflammation that drives depression. These star-shaped brain cells, once thought to only support neurons, are now shown to regulate communication between brain cells and even trigger or amplify inflammatory responses. Tue, 24 Jun 2025 11:19:12 EDT https://www.sciencedaily.com/releases/2025/06/250624044330.htm https://www.sciencedaily.com/releases/2025/06/250602155806.htm Chronic inflammatory bowel disease is challenging to treat and carries a risk of complications, including the development of bowel cancer. Young people are particularly affected: when genetic predisposition and certain factors coincide, diseases such as ulcerative colitis or Crohn's disease usually manifest between the ages of 15 and 29 -- a critical period for education and early career development. Prompt diagnosis and treatment are crucial. Researchers have now discovered a therapeutic target that significantly contributes to halting the ongoing inflammatory processes. Mon, 02 Jun 2025 15:58:06 EDT https://www.sciencedaily.com/releases/2025/06/250602155806.htm https://www.sciencedaily.com/releases/2025/06/250602155508.htm Aortic valve narrowing (aortic stenosis) with concomitant cardiac amyloidosis is a severe heart disease of old age that is associated with a high risk of death. Until now, treatment has consisted of valve replacement, while the deposits in the heart muscle, known as amyloidosis, often remain untreated. Researchers have now demonstrated that combined treatment consisting of heart valve replacement and specific drug therapy offers a significant survival advantage for patients. Mon, 02 Jun 2025 15:55:08 EDT https://www.sciencedaily.com/releases/2025/06/250602155508.htm https://www.sciencedaily.com/releases/2025/05/250527180932.htm A new study reveals the biological secret to the Zika virus's infectious success: Zika uses host cells' own 'self-care' system of clearing away useless molecules to suppress the host proteins that the virus has employed to get into those cells in the first place. Tue, 27 May 2025 18:09:32 EDT https://www.sciencedaily.com/releases/2025/05/250527180932.htm https://www.sciencedaily.com/releases/2025/05/250522124611.htm When the workload on the heart increases, the ventricular wall may thicken too, known as cardiac hypertrophy. This is an adaptive response that reduces pressure on the heart and maintains the activity of this vital organ. It is often a reversible process that does not cause serious effects on the structure or function of the heart, but if the factor causing cardiac overload becomes chronic, it can lead to pathological hypertrophy with more serious effects (dilatation of the ventricular cavities, alterations in cardiac function, heart failure, etc.). Thu, 22 May 2025 12:46:11 EDT https://www.sciencedaily.com/releases/2025/05/250522124611.htm https://www.sciencedaily.com/releases/2025/05/250521124752.htm Bats are known as natural hosts for highly pathogenic viruses such as MERS- and SARS-related coronaviruses, as well as the Marburg and Nipah viruses. In contrast to the severe and often fatal disease outcomes these viruses cause in humans, bats generally do not show obvious signs of viral illness following infection. An international research team has developed an innovative organoid research platform that allowed them to closely investigate the cellular antiviral defense mechanisms of mucosal epithelial tissues of bats. The results could pave the way for the development of new therapies against viral diseases. Wed, 21 May 2025 12:47:52 EDT https://www.sciencedaily.com/releases/2025/05/250521124752.htm https://www.sciencedaily.com/releases/2025/05/250520121152.htm By studying Chikungunya virus, scientists shed light on how immune responses to viral infections may lead to persistent symptoms of autoimmune disease. Tue, 20 May 2025 12:11:52 EDT https://www.sciencedaily.com/releases/2025/05/250520121152.htm https://www.sciencedaily.com/releases/2025/05/250519131815.htm A study has become the first in the world to unravel the immediate effects of a high-fat diet on our gut health. Mon, 19 May 2025 13:18:15 EDT https://www.sciencedaily.com/releases/2025/05/250519131815.htm https://www.sciencedaily.com/releases/2025/05/250519131253.htm Researchers have published the first description of the role of the ZFP36 family of RNA binding proteins in regulatory T cells (Tregs). Tregs are key to maintaining balance in the immune system and essential to preventing autoimmune disease. By the targeted deletion of Zfp36l1 and Zfp36l2 in Tregs in mice, the findings demonstrate that loss of these RNA binding proteins results in Tregs no longer being able to control other immune cell types, which results in inflammation. The data point to a key role of ZFP36L1 and ZFP36L2 in governing multiple cytokine responses in Tregs, including regulating the availability of the cytokine interferon-gamma, which activates immune responses, as well as being important in maintaining Treg stability. Mon, 19 May 2025 13:12:53 EDT https://www.sciencedaily.com/releases/2025/05/250519131253.htm https://www.sciencedaily.com/releases/2025/05/250512165549.htm Researchers confirm and explore the role of estrogen-related receptors in regulating energy production in muscle cells during exercise. The findings indicate that developing a drug to boost estrogen-related receptors could be a powerful way to restore energy supplies in people with metabolic disorders, such as muscular dystrophy. Mon, 12 May 2025 16:55:49 EDT https://www.sciencedaily.com/releases/2025/05/250512165549.htm https://www.sciencedaily.com/releases/2025/05/250509122250.htm How does obesity affect insulin production? Researchers are shining light on new stages of the ERK pathway. Fri, 09 May 2025 12:22:50 EDT https://www.sciencedaily.com/releases/2025/05/250509122250.htm https://www.sciencedaily.com/releases/2025/05/250508113129.htm Researchers have developed cutting-edge MRI technology to diagnose a common heart problem more quickly and accurately than ever before. Aortic stenosis is a progressive and potentially fatal condition, affecting about five per cent of 65-year-olds in the US -- with increasing prevalence in advancing age. Symptoms include chest pains, a rapid fluttering heartbeat and feeling dizzy, short of breath and fatigued -- particularly with activity. The new study reveals how a four-dimensional flow (4D flow) MRI scan can diagnose aortic stenosis more reliably than current ultrasound techniques. The superior accuracy of the new test means doctors can better predict when patients will require surgery. Thu, 08 May 2025 11:31:29 EDT https://www.sciencedaily.com/releases/2025/05/250508113129.htm https://www.sciencedaily.com/releases/2025/05/250501164002.htm A new approach to drug design can deliver medicine directly to the gut in mice at significantly lower doses than current inflammatory bowel disease treatments. The proof-of-concept study introduced a mechanism called 'GlycoCaging' that releases medicine exclusively to the lower gut at doses up to 10 times lower than current therapies. Thu, 01 May 2025 16:40:02 EDT https://www.sciencedaily.com/releases/2025/05/250501164002.htm https://www.sciencedaily.com/releases/2025/04/250430142954.htm Australia's recent move to lower the starting age for bowel (colorectal) cancer screening from 50 down to 45 years old will mean better outcomes -- but it will also increase the burden on an already struggling healthcare system, warn researchers. They predict that the expanded screening program will likely lead to an influx of younger adults who will require ongoing surveillance with regular colonoscopies, prompting the team to review current clinical guidelines for at risk individuals. Wed, 30 Apr 2025 14:29:54 EDT https://www.sciencedaily.com/releases/2025/04/250430142954.htm https://www.sciencedaily.com/releases/2025/04/250421162945.htm A new study found that the oral and extended-release injectable forms of naltrexone are equally effective in helping patients consume less alcohol, suggesting that clinicians should integrate this medication into routine hospital care. Mon, 21 Apr 2025 16:29:45 EDT https://www.sciencedaily.com/releases/2025/04/250421162945.htm https://www.sciencedaily.com/releases/2025/04/250418112635.htm When the immune system does not function properly, individuals become more susceptible to infections caused by viruses, bacteria, or fungi. Researchers have demonstrated that an existing drug can revive immune cells that are not functioning correctly. These findings provide leads for further research in patients admitted to the intensive care unit (ICU) with sepsis. Fri, 18 Apr 2025 11:26:35 EDT https://www.sciencedaily.com/releases/2025/04/250418112635.htm https://www.sciencedaily.com/releases/2025/04/250416135743.htm Researchers have made significant advancements in understanding the earliest stages of stomach cancer, a leading cause of cancer-related deaths worldwide, through two recent innovative studies. With a prevalence rates particularly high in East Asia, including China, this cancer often stems from chronic inflammation caused by Helicobacter pylori infection, which affects approximately 15% of the Hong Kong population. This inflammation can lead to a pre-cancerous stage known as intestinal metaplasia. The innovative studies have uncovered crucial insights into the earliest changes in the stomach that contribute to the development of stomach cancer, laying the foundation for improved prevention and early detection, ultimately saving lives. Wed, 16 Apr 2025 13:57:43 EDT https://www.sciencedaily.com/releases/2025/04/250416135743.htm https://www.sciencedaily.com/releases/2025/04/250410160714.htm Researchers identified a direct connection between cancer-related inflammation and the loss of motivation characteristic of advanced cancer. In a mouse study, they describe a brain pathway that starts with neurons (labeled in green, above) that sense inflammation signals, and the researchers were able to treat the loss of motivation by blocking this pathway. Thu, 10 Apr 2025 16:07:14 EDT https://www.sciencedaily.com/releases/2025/04/250410160714.htm https://www.sciencedaily.com/releases/2025/04/250409154604.htm A small protein involved in neurodegeneration leading to Parkinson's disease also drives a type of skin cancer known as melanoma, according to new research. Wed, 09 Apr 2025 15:46:04 EDT https://www.sciencedaily.com/releases/2025/04/250409154604.htm https://www.sciencedaily.com/releases/2025/04/250403143837.htm In the fight against bacterial pathogens, researchers are combining vaccination with targeted colonization of the intestine by harmless microorganisms. This approach could potentially mark a turning point in the antibiotics crisis. Thu, 03 Apr 2025 14:38:37 EDT https://www.sciencedaily.com/releases/2025/04/250403143837.htm