https://www.sciencedaily.com/news/mind_brain/alzheimer's/ Learn about Alzheimer's Disease symptoms such as memory loss and senile dementia. Find out about the treatments and causes, as well as the stages of Alzheimer's Disease and dementia. en-us Fri, 06 Mar 2026 02:06:42 EST Fri, 06 Mar 2026 02:06:42 EST 60 https://www.sciencedaily.com/images/scidaily-logo-rss.png https://www.sciencedaily.com/news/mind_brain/alzheimer's/ For more science news, visit ScienceDaily. https://www.sciencedaily.com/releases/2026/02/260224023159.htm Subtle changes in brain blood flow and oxygen use are closely linked to hallmark signs of Alzheimer’s, including amyloid plaques and memory-related brain shrinkage. Simple, noninvasive scans may one day help spot risk earlier—by looking at the brain’s vascular health, not just its plaques. Tue, 24 Feb 2026 10:21:58 EST https://www.sciencedaily.com/releases/2026/02/260224023159.htm https://www.sciencedaily.com/releases/2026/02/260222085203.htm Scientists have created a blood test that can estimate when Alzheimer’s symptoms are likely to begin. By measuring a protein called p-tau217, the model predicts symptom onset within roughly three to four years. The protein mirrors the silent buildup of amyloid and tau in the brain long before memory loss appears. This advance could speed up preventive drug trials and eventually guide personalized care. Mon, 23 Feb 2026 06:46:07 EST https://www.sciencedaily.com/releases/2026/02/260222085203.htm https://www.sciencedaily.com/releases/2026/02/260215225555.htm Researchers have identified two brain receptors that help the brain clear away amyloid beta, a hallmark of Alzheimer’s disease. By stimulating these receptors in mice, scientists increased levels of a natural amyloid-breaking enzyme, reduced buildup in the brain, and improved memory-related behavior. Because these receptors are common drug targets, the findings could open the door to affordable pill-based treatments with fewer side effects. Tue, 17 Feb 2026 05:30:08 EST https://www.sciencedaily.com/releases/2026/02/260215225555.htm https://www.sciencedaily.com/releases/2026/02/260211073023.htm A simple brain-training program that sharpens how quickly older adults process visual information may have a surprisingly powerful long-term payoff. In a major 20-year study of adults 65 and older, those who completed five to six weeks of adaptive “speed of processing” training — along with a few booster sessions — were significantly less likely to develop dementia, including Alzheimer’s disease, even two decades later. Participants who received the boosted speed training had a 25% lower dementia risk compared to those who received no training, making it the only intervention in the trial to show such a lasting protective effect. Wed, 11 Feb 2026 22:15:24 EST https://www.sciencedaily.com/releases/2026/02/260211073023.htm https://www.sciencedaily.com/releases/2026/02/260206012213.htm Scientists have uncovered promising clues that compounds found in Aloe vera could play a role in fighting Alzheimer’s disease. Using advanced computer modeling, researchers discovered that beta-sitosterol—a natural plant compound—strongly interacts with two key enzymes involved in memory loss and cognitive decline. The compound showed stability, strong binding, and favorable safety indicators, making it a standout candidate for future drug development. Sun, 08 Feb 2026 07:57:41 EST https://www.sciencedaily.com/releases/2026/02/260206012213.htm https://www.sciencedaily.com/releases/2026/02/260203030540.htm A massive Swedish study tracking nearly 28,000 people for 25 years found an unexpected link between full-fat dairy and brain health. Among adults without a genetic risk for Alzheimer’s, eating more full-fat cheese was associated with a noticeably lower risk of developing the disease, while higher cream intake was tied to reduced dementia risk overall. The findings challenge decades of low-fat dietary advice but come with important caveats. Wed, 04 Feb 2026 09:44:17 EST https://www.sciencedaily.com/releases/2026/02/260203030540.htm https://www.sciencedaily.com/releases/2026/02/260203020203.htm A new brain imaging study reveals that remembering facts and recalling life events activate nearly identical brain networks. Researchers expected clear differences but instead found strong overlap across memory types. The finding challenges decades of memory research. It may also help scientists better understand conditions like Alzheimer’s and dementia. Tue, 03 Feb 2026 02:17:32 EST https://www.sciencedaily.com/releases/2026/02/260203020203.htm https://www.sciencedaily.com/releases/2026/02/260201062459.htm When the brain rests, it usually replays recent experiences to strengthen memory. Scientists found that in Alzheimer’s-like mice, this replay still occurs — but the signals are jumbled and poorly coordinated. As a result, memory-supporting brain cells lose their stability, and the animals struggle to remember where they’ve been. Sun, 01 Feb 2026 10:41:29 EST https://www.sciencedaily.com/releases/2026/02/260201062459.htm https://www.sciencedaily.com/releases/2026/01/260126231847.htm A new genetic study suggests that obesity and high blood pressure may play a direct role in causing dementia, not just increasing the risk. By analyzing data from large populations in Denmark and the U.K., researchers found strong evidence that higher body weight can damage brain health over time, especially when it leads to elevated blood pressure. Much of the dementia risk appeared to be tied to vascular damage in the brain, which affects blood flow and cognitive function. Mon, 26 Jan 2026 23:18:47 EST https://www.sciencedaily.com/releases/2026/01/260126231847.htm https://www.sciencedaily.com/releases/2026/01/260125083413.htm Alzheimer’s may destroy memory by flipping a single molecular switch that tells neurons to prune their own connections. Researchers found that both amyloid beta and inflammation converge on the same receptor, triggering synapse loss. Surprisingly, neurons aren’t passive victims—they actively respond to these signals. Targeting this receptor could offer a new way to protect memory beyond current amyloid-focused drugs. Mon, 26 Jan 2026 03:08:27 EST https://www.sciencedaily.com/releases/2026/01/260125083413.htm https://www.sciencedaily.com/releases/2026/01/260122073623.htm Alzheimer’s may be driven far more by genetics than previously thought, with one gene playing an outsized role. Researchers found that up to nine in ten cases could be linked to the APOE gene — even including a common version once considered neutral. The discovery reshapes how scientists think about risk and prevention. It also highlights a major opportunity for new treatments aimed at a single biological pathway. Fri, 23 Jan 2026 10:16:38 EST https://www.sciencedaily.com/releases/2026/01/260122073623.htm https://www.sciencedaily.com/releases/2026/01/260118233547.htm Cannabis-based medicines have been widely promoted as a potential answer for people living with chronic nerve pain—but a major new review finds the evidence just isn’t there yet. After analyzing more than 20 clinical trials involving over 2,100 adults, researchers found no strong proof that cannabis products outperform placebos in relieving neuropathic pain. Even when small improvements were reported, especially with THC-CBD combinations, they weren’t large enough to make a real difference in daily life. Mon, 19 Jan 2026 00:11:47 EST https://www.sciencedaily.com/releases/2026/01/260118233547.htm https://www.sciencedaily.com/releases/2026/01/260116035348.htm Researchers have identified OTULIN, an immune-regulating enzyme, as a key trigger of tau buildup in the brain. When OTULIN was disabled, tau vanished from neurons and brain cells remained healthy. The findings challenge long-held assumptions about tau’s necessity and highlight a promising new path for fighting Alzheimer’s and brain aging. Scientists now believe OTULIN may act as a master switch for inflammation and age-related brain decline. Fri, 16 Jan 2026 03:53:48 EST https://www.sciencedaily.com/releases/2026/01/260116035348.htm https://www.sciencedaily.com/releases/2026/01/260114084107.htm A massive international brain study has revealed that memory decline with age isn’t driven by a single brain region or gene, but by widespread structural changes across the brain that build up over time. Analyzing thousands of MRI scans and memory tests from healthy adults, researchers found that memory loss accelerates as brain tissue shrinkage increases, especially later in life. While the hippocampus plays a key role, many other brain regions also contribute, forming a broad vulnerability rather than isolated damage. Wed, 14 Jan 2026 09:56:10 EST https://www.sciencedaily.com/releases/2026/01/260114084107.htm https://www.sciencedaily.com/releases/2026/01/260112001041.htm Researchers have discovered a brain activity pattern that can predict which people with mild cognitive impairment are likely to develop Alzheimer’s disease. Using a noninvasive brain scanning technique and a custom analysis tool, they detected subtle changes in electrical signals tied to memory processing years before diagnosis. The findings point to a new way of spotting Alzheimer’s early—by listening directly to how neurons behave. Mon, 12 Jan 2026 09:24:19 EST https://www.sciencedaily.com/releases/2026/01/260112001041.htm https://www.sciencedaily.com/releases/2026/01/260103155026.htm Your daily rhythm may matter more for brain health than previously thought. Older adults with weaker, more disrupted activity patterns were far more likely to develop dementia than those with steady routines. A later daily energy peak was also linked to higher risk. The study points to the body clock as a possible early warning sign for cognitive decline. Sat, 03 Jan 2026 19:52:00 EST https://www.sciencedaily.com/releases/2026/01/260103155026.htm https://www.sciencedaily.com/releases/2025/12/251228020016.htm Researchers discovered that clogged brain “drains” show up early in people at risk of Alzheimer’s disease. These blockages, easily seen on standard MRI scans, are tied to toxic protein buildup linked to memory loss and cognitive decline. In some cases, they may signal Alzheimer’s earlier than other commonly used brain markers. This could help physicians detect the disease earlier, before irreversible damage sets in. Sat, 03 Jan 2026 00:45:11 EST https://www.sciencedaily.com/releases/2025/12/251228020016.htm https://www.sciencedaily.com/releases/2025/12/251224015651.htm Cannabis products with higher THC levels may slightly reduce chronic pain, particularly nerve pain, according to a review of multiple clinical trials. The improvement was small and short-lived, while side effects were more common. Products with little or no THC, including CBD-only formulations, showed no clear benefit. Researchers say more long-term studies are needed. Tue, 30 Dec 2025 20:44:59 EST https://www.sciencedaily.com/releases/2025/12/251224015651.htm https://www.sciencedaily.com/releases/2025/12/251222080119.htm New research suggests Alzheimer’s may start far earlier than previously thought, driven by a hidden toxic protein in the brain. Scientists found that an experimental drug, NU-9, blocks this early damage in mice and reduces inflammation linked to disease progression. The treatment was given before symptoms appeared, targeting the disease at its earliest stage. Researchers say this approach could reshape how Alzheimer’s is prevented and treated. Mon, 22 Dec 2025 08:11:02 EST https://www.sciencedaily.com/releases/2025/12/251222080119.htm https://www.sciencedaily.com/releases/2025/12/251221091246.htm Eating full-fat cheese and cream may be associated with a lower risk of dementia, according to a large study that tracked people for more than 25 years. Those who consumed higher amounts of these foods developed dementia less often than those who ate little or none. Interestingly, low-fat dairy products did not show the same pattern. Researchers caution that the findings show an association, not cause and effect. Sun, 21 Dec 2025 23:52:31 EST https://www.sciencedaily.com/releases/2025/12/251221091246.htm https://www.sciencedaily.com/releases/2025/12/251210092019.htm Obesity accelerates the rise of Alzheimer’s-related blood biomarkers far more rapidly than previously recognized. Long-term imaging and plasma data show that obese individuals experience much faster increases in proteins linked to neurodegeneration and amyloid buildup. Surprisingly, blood tests detected these changes earlier than PET scans. The results point to obesity as a major, modifiable contributor to Alzheimer’s progression. Wed, 10 Dec 2025 12:23:51 EST https://www.sciencedaily.com/releases/2025/12/251210092019.htm https://www.sciencedaily.com/releases/2025/12/251208052804.htm Researchers discovered that a tiny structural feature of the enzyme GPX4 helps keep neurons safe. A rare mutation removes this protection, allowing harmful molecules to damage cell membranes and trigger early dementia. Mouse and cell studies showed changes resembling Alzheimer’s. Early tests to slow this damage give scientists new directions to explore. Tue, 09 Dec 2025 04:12:54 EST https://www.sciencedaily.com/releases/2025/12/251208052804.htm https://www.sciencedaily.com/releases/2025/12/251203004721.htm A unique vaccine rollout in Wales gave researchers an accidental natural experiment that revealed a striking reduction in dementia among seniors who received the shingles vaccine. The protective effect held steady across multiple analyses and was even stronger in women. Evidence also suggests benefits for people who already have dementia, hinting at a therapeutic effect. Wed, 03 Dec 2025 10:22:27 EST https://www.sciencedaily.com/releases/2025/12/251203004721.htm https://www.sciencedaily.com/releases/2025/11/251130050712.htm Scientists have uncovered a stepwise system that guides how the brain sorts and stabilizes lasting memories. By tracking brain activity during virtual reality learning tasks, researchers identified molecules that influence how long memories persist. Each molecule operates on a different timescale, forming a coordinated pattern of memory maintenance. The discoveries reshape how scientists understand memory formation. Sun, 30 Nov 2025 06:13:16 EST https://www.sciencedaily.com/releases/2025/11/251130050712.htm https://www.sciencedaily.com/releases/2025/11/251127010319.htm Scientists studying young adults with obesity discovered early indicators of brain stress that resemble patterns seen in cognitive impairment. The group showed higher inflammation, signs of liver strain and elevated neurofilament light chain, a marker of neuron injury. Low choline levels appeared closely tied to these changes. The results hint that early metabolic disruptions may quietly influence the brain long before symptoms emerge. Thu, 27 Nov 2025 02:45:12 EST https://www.sciencedaily.com/releases/2025/11/251127010319.htm https://www.sciencedaily.com/releases/2025/11/251126095023.htm Spermine, a small but powerful molecule in the body, helps neutralize harmful protein accumulations linked to Alzheimer’s and Parkinson’s. It encourages these misfolded proteins to gather into manageable clumps that cells can more efficiently dispose of through autophagy. Experiments in nematodes show that spermine also enhances longevity and cellular energy production. These insights open the door to targeted therapies powered by polyamines and advanced AI-driven molecular design. Thu, 27 Nov 2025 07:35:52 EST https://www.sciencedaily.com/releases/2025/11/251126095023.htm https://www.sciencedaily.com/releases/2025/11/251123085550.htm Researchers discovered that raising the protein Sox9 can help the brain’s astrocytes clear out toxic plaque buildup linked to Alzheimer’s. In mouse models that already showed memory problems, activating these cells improved cognitive performance. The treatment also reduced plaque levels over time. The work points toward a natural, cell-based way to slow Alzheimer’s decline. Sun, 23 Nov 2025 09:23:57 EST https://www.sciencedaily.com/releases/2025/11/251123085550.htm https://www.sciencedaily.com/releases/2025/11/251121090731.htm Researchers discovered that the common amino acid arginine can block harmful Aβ aggregation and reduce its toxic effects in Alzheimer’s disease models. In flies and mice, oral arginine lowered plaque levels, reduced inflammation, and improved behavior. Its strong safety record and low cost make it a promising repurposing candidate. The findings hint at a surprisingly simple path toward more accessible AD therapies. Fri, 21 Nov 2025 11:33:04 EST https://www.sciencedaily.com/releases/2025/11/251121090731.htm https://www.sciencedaily.com/releases/2025/11/251118220052.htm Scientists have developed a new molecule that breaks down beta-amyloid plaques by binding to excess copper in the brain. The treatment restored memory and reduced inflammation in rats, while also proving non-toxic and able to cross the blood–brain barrier. Because it’s far simpler and potentially cheaper than existing drugs, researchers are now pursuing partnerships to begin human trials. Wed, 19 Nov 2025 10:46:50 EST https://www.sciencedaily.com/releases/2025/11/251118220052.htm https://www.sciencedaily.com/releases/2025/11/251111005944.htm Japanese researchers found that lecanemab, an amyloid-clearing drug for Alzheimer’s, does not improve the brain’s waste clearance system in the short term. This implies that nerve damage and impaired clearance occur early and are difficult to reverse. Their findings underscore that tackling amyloid alone may not be enough to restore brain function, urging a broader approach to treatment. Tue, 11 Nov 2025 01:47:33 EST https://www.sciencedaily.com/releases/2025/11/251111005944.htm https://www.sciencedaily.com/releases/2025/11/251106003155.htm Weill Cornell researchers uncovered how free radicals from astrocyte mitochondria can fuel dementia. Using new compounds that target these radicals at their source, they slowed brain inflammation and neuronal damage in mice. The findings reveal a potential breakthrough for treating diseases like Alzheimer’s and frontotemporal dementia by focusing on the precise mechanisms driving degeneration. Thu, 06 Nov 2025 00:31:55 EST https://www.sciencedaily.com/releases/2025/11/251106003155.htm https://www.sciencedaily.com/releases/2025/11/251105050720.htm Virginia Tech researchers have shown that memory loss in aging may be reversible. Using CRISPR tools, they corrected molecular disruptions in the hippocampus and amygdala, restoring memory in older rats. Another experiment revived a silenced memory gene, IGF2, through targeted DNA methylation editing. These findings highlight that aging brains can regain function through precise molecular intervention. Wed, 05 Nov 2025 22:55:58 EST https://www.sciencedaily.com/releases/2025/11/251105050720.htm https://www.sciencedaily.com/releases/2025/11/251104013008.htm Walking a few thousand steps daily may help hold off Alzheimer’s for years, a Mass General Brigham study found. Even moderate physical activity slowed both cognitive decline and the buildup of harmful tau proteins in the brain. The researchers say these results show lifestyle changes can meaningfully delay Alzheimer’s symptoms, especially in early stages. Tue, 04 Nov 2025 09:16:57 EST https://www.sciencedaily.com/releases/2025/11/251104013008.htm https://www.sciencedaily.com/releases/2025/11/251102205012.htm Disrupted sleep patterns in Alzheimer’s disease may be more than a symptom—they could be a driving force. Researchers at Washington University found that the brain’s circadian rhythms are thrown off in key cell types, changing when hundreds of genes turn on and off. This disruption, triggered by amyloid buildup, scrambles normal gene timing in microglia and astrocytes—cells vital for brain maintenance and immune defense. Mon, 03 Nov 2025 01:25:26 EST https://www.sciencedaily.com/releases/2025/11/251102205012.htm https://www.sciencedaily.com/releases/2025/10/251029100154.htm Researchers used supramolecular nanoparticles to repair the brain’s vascular system and reverse Alzheimer’s in mice. Instead of carrying drugs, the nanoparticles themselves triggered natural clearance of amyloid-β proteins. This restored blood-brain barrier function and reversed memory loss. The results point to a revolutionary new path for treating neurodegenerative diseases. Wed, 29 Oct 2025 10:01:54 EDT https://www.sciencedaily.com/releases/2025/10/251029100154.htm https://www.sciencedaily.com/releases/2025/10/251022023113.htm Scientists have uncovered a toxic alliance between Aβ and fibrinogen that may explain how Alzheimer’s disease begins. The two proteins together create stubborn clots that damage blood vessels and spark inflammation in the brain. These effects appear even at very low concentrations and disrupt the blood-brain barrier, paving the way for neurodegeneration. The findings highlight a potential new therapeutic target for early intervention. Wed, 22 Oct 2025 09:19:26 EDT https://www.sciencedaily.com/releases/2025/10/251022023113.htm https://www.sciencedaily.com/releases/2025/10/251018102118.htm SuperAgers defy normal aging by keeping sharp memories and healthy brains well into their 80s. Northwestern scientists discovered that these individuals either resist the buildup of harmful brain proteins or remain unaffected by them. Their brains stay structurally youthful, and their strong social lives may help protect cognition. The findings could inspire new ways to delay or prevent dementia. Sun, 19 Oct 2025 09:45:18 EDT https://www.sciencedaily.com/releases/2025/10/251018102118.htm https://www.sciencedaily.com/releases/2025/10/251014014312.htm Researchers have synthesized enhanced vitamin K analogues that outperform natural vitamin K in promoting neuron growth. The new compounds, which combine vitamin K with retinoic acid, activate the mGluR1 receptor to drive neurogenesis. They also efficiently cross the blood-brain barrier and show stability in vivo. This discovery could pave the way for regenerative treatments for Alzheimer’s and related diseases. Tue, 14 Oct 2025 11:08:36 EDT https://www.sciencedaily.com/releases/2025/10/251014014312.htm https://www.sciencedaily.com/releases/2025/10/251004092919.htm A massive new study combining observational and genetic data overturns the long-held belief that light drinking protects the brain. Researchers found that dementia risk rises in direct proportion to alcohol consumption, with no safe level identified. Sat, 04 Oct 2025 23:42:39 EDT https://www.sciencedaily.com/releases/2025/10/251004092919.htm https://www.sciencedaily.com/releases/2025/10/251003033915.htm New research from Houston Methodist reveals how obesity may directly drive Alzheimer’s disease. Scientists discovered that tiny messengers released by fat tissue, called extracellular vesicles, can carry harmful signals that accelerate the buildup of amyloid-β plaques in the brain. These vesicles even cross the blood–brain barrier, making them powerful but dangerous connectors between body fat and brain health. Fri, 03 Oct 2025 03:39:15 EDT https://www.sciencedaily.com/releases/2025/10/251003033915.htm https://www.sciencedaily.com/releases/2025/09/250927031217.htm Researchers in Japan discovered that Parkinson’s patients diagnosed in their 80s are far more likely to show signs of amyloid buildup, a hallmark of Alzheimer’s, even without dementia symptoms. The study compared younger and older patients, finding that older individuals had three times the rate of amyloid positivity. Surprisingly, Parkinson’s patients overall showed lower amyloid buildup than healthy people their age, suggesting that Parkinson’s might change the way Alzheimer’s-related processes unfold in the brain. Sun, 28 Sep 2025 00:23:03 EDT https://www.sciencedaily.com/releases/2025/09/250927031217.htm https://www.sciencedaily.com/releases/2025/09/250924012257.htm For decades, scientists believed Alzheimer’s was driven mainly by sticky protein plaques and tangles in the brain. Now Purdue researchers have revealed a hidden culprit: fat. They found that brain immune cells can become clogged with fat, leaving them too weak to fight off disease. By clearing out this fat and restoring the cells’ defenses, researchers may have uncovered an entirely new way to combat Alzheimer’s — shifting the focus from plaques alone to how the brain handles fat. Wed, 24 Sep 2025 23:56:50 EDT https://www.sciencedaily.com/releases/2025/09/250924012257.htm https://www.sciencedaily.com/releases/2025/09/250913232924.htm Chronic insomnia may do more than leave you groggy, it could speed up brain aging. A large Mayo Clinic study found that people with long-term sleep troubles were 40% more likely to develop dementia or cognitive impairment, with brain scans showing changes linked to Alzheimer’s. Those reporting reduced sleep showed declines comparable to being four years older, while certain genetic risk carriers saw even steeper drops. Sun, 14 Sep 2025 02:02:57 EDT https://www.sciencedaily.com/releases/2025/09/250913232924.htm https://www.sciencedaily.com/releases/2025/09/250909031511.htm Scientists discovered that certain blood proteins linked to brain injury and inflammation strongly correlate with early signs of memory and cognitive decline, especially in Hispanic and Latino adults. This breakthrough points to a future where Alzheimer’s could be detected early with a simple blood test. Tue, 09 Sep 2025 22:05:55 EDT https://www.sciencedaily.com/releases/2025/09/250909031511.htm https://www.sciencedaily.com/releases/2025/09/250904014153.htm Scientists at the University of Bath have developed a simple three-minute brainwave test called Fastball EEG that can detect memory problems years before Alzheimer’s is typically diagnosed. Unlike traditional memory tests, it passively records brain responses to images and has now been proven effective in people’s homes. With breakthrough Alzheimer’s drugs working best in early stages, this low-cost, accessible tool could transform early detection and treatment. Thu, 04 Sep 2025 03:12:51 EDT https://www.sciencedaily.com/releases/2025/09/250904014153.htm https://www.sciencedaily.com/releases/2025/09/250901104647.htm A sweeping review of nearly 100 studies has raised concerns about the mental health impacts of high-potency cannabis products. Researchers found strong links to psychosis, schizophrenia, and cannabis use disorder, while results for anxiety and depression were mixed and sometimes contradictory. Although the findings confirm that higher THC concentrations pose risks, the evidence still isn’t clear enough to offer firm clinical guidance, leaving scientists calling for better-designed studies to fill the gaps. Tue, 02 Sep 2025 03:11:31 EDT https://www.sciencedaily.com/releases/2025/09/250901104647.htm https://www.sciencedaily.com/releases/2025/08/250829022829.htm Harvard scientists have uncovered that lithium, a naturally occurring element in the brain, may be the missing piece in understanding Alzheimer’s. Their decade-long research shows that lithium depletion—caused by amyloid plaques binding to it—triggers early brain changes that lead to memory loss. By testing new lithium compounds that evade plaque capture, they reversed Alzheimer’s-like damage and restored memory in mice at doses far lower than those used in psychiatric treatments. Fri, 29 Aug 2025 02:57:32 EDT https://www.sciencedaily.com/releases/2025/08/250829022829.htm https://www.sciencedaily.com/releases/2025/08/250828002404.htm Using cannabis to self-medicate comes with hidden dangers—new research shows these users face higher paranoia and consume more THC. Childhood trauma further amplifies the risks, especially emotional abuse, which strongly predicts paranoia. Thu, 28 Aug 2025 00:24:04 EDT https://www.sciencedaily.com/releases/2025/08/250828002404.htm https://www.sciencedaily.com/releases/2025/08/250822073817.htm St. Jude researchers revealed that midkine blocks amyloid beta from forming harmful clumps linked to Alzheimer’s. Without it, the damaging assemblies accelerate, but with it, growth halts. The finding could inspire new drugs that harness midkine’s protective power. Sat, 23 Aug 2025 10:21:32 EDT https://www.sciencedaily.com/releases/2025/08/250822073817.htm https://www.sciencedaily.com/releases/2025/08/250811104237.htm THC levels in cannabis have soared in recent years, raising the risk of psychosis—especially in young, frequent users. Studies reveal a strong connection between cannabis-induced psychosis and schizophrenia, making early cessation and treatment essential. Tue, 12 Aug 2025 12:07:56 EDT https://www.sciencedaily.com/releases/2025/08/250811104237.htm https://www.sciencedaily.com/releases/2025/08/250811104227.htm Scientists have discovered a direct cause-and-effect link between faulty mitochondria and the memory loss seen in neurodegenerative diseases. By creating a novel tool to boost mitochondrial activity in mouse models, researchers restored memory performance, suggesting mitochondria could be a powerful new target for treatments. The findings not only shed light on the early drivers of brain cell degeneration but also open possibilities for slowing or even preventing diseases like Alzheimer’s. Tue, 12 Aug 2025 04:02:29 EDT https://www.sciencedaily.com/releases/2025/08/250811104227.htm https://www.sciencedaily.com/releases/2025/07/250727235823.htm Many people with dementia endure long delays often over 3 years before receiving a diagnosis, with even longer waits for younger patients. A global review of over 30,000 cases reveals that age, dementia type, and systemic healthcare issues like specialist access and cultural barriers contribute to these delays. Researchers call for coordinated strategies to raise public awareness, reduce stigma, and train clinicians to recognize early symptoms and streamline referrals. Sun, 27 Jul 2025 23:58:23 EDT https://www.sciencedaily.com/releases/2025/07/250727235823.htm https://www.sciencedaily.com/releases/2025/07/250726234423.htm Scientists at UCSF have uncovered how certain immune cells in the brain, called microglia, can effectively digest toxic amyloid beta plaques that cause Alzheimer’s. They identified a key receptor, ADGRG1, that enables this protective action. When microglia lack this receptor, plaque builds up quickly, causing memory loss and brain damage. But when the receptor is present, it seems to help keep Alzheimer's symptoms mild. Since ADGRG1 belongs to a drug-friendly family of receptors, this opens the door to future therapies that could enhance brain immunity and protect against Alzheimer’s in more people. Sun, 27 Jul 2025 08:35:56 EDT https://www.sciencedaily.com/releases/2025/07/250726234423.htm https://www.sciencedaily.com/releases/2025/06/250620231852.htm USC researchers have uncovered a hidden driver behind the early and severe onset of Alzheimer's in people with Down syndrome: iron overload in the brain. Their study revealed that individuals with both conditions had twice the iron levels and far more oxidative damage than others. The culprit appears to be ferroptosis, an iron-triggered cell death mechanism, which is especially damaging in sensitive brain regions. Fri, 20 Jun 2025 23:18:52 EDT https://www.sciencedaily.com/releases/2025/06/250620231852.htm https://www.sciencedaily.com/releases/2025/06/250602154905.htm A new way of thinking about Alzheimer's disease has yielded a discovery that could be the key to stopping the cognitive decline seen in Alzheimer's and other neurodegenerative diseases, including ALS and Parkinson's. Mon, 02 Jun 2025 15:49:05 EDT https://www.sciencedaily.com/releases/2025/06/250602154905.htm https://www.sciencedaily.com/releases/2025/05/250530124112.htm New research has found that men who carry a common genetic variant are twice as likely to develop dementia in their lifetime compared to women. Fri, 30 May 2025 12:41:12 EDT https://www.sciencedaily.com/releases/2025/05/250530124112.htm https://www.sciencedaily.com/releases/2025/05/250528131549.htm Scientists found that stabilizing stress granules suppresses the effects of ALS-causing mutations, correcting previous models that imply stress granules promote amyloid formation. Wed, 28 May 2025 13:15:49 EDT https://www.sciencedaily.com/releases/2025/05/250528131549.htm https://www.sciencedaily.com/releases/2025/05/250528131547.htm A new study finds that chronic cannabis use -- whether it's smoked or consumed in edible form -- is associated with significant cardiovascular risks. Wed, 28 May 2025 13:15:47 EDT https://www.sciencedaily.com/releases/2025/05/250528131547.htm https://www.sciencedaily.com/releases/2025/05/250516133225.htm While Alzheimer's disease is mostly considered a disorder of the brain, emerging evidence suggests that the condition also affects other organs of the body. Working with the laboratory fruit fly, researchers provide a new understanding of how Alzheimer's disease affects different tissues across the entire body. The findings reveal new insights into brain-body communication in neurodegeneration and pave the way for identifying novel biomarkers and therapeutic targets for Alzheimer's disease. Fri, 16 May 2025 13:32:25 EDT https://www.sciencedaily.com/releases/2025/05/250516133225.htm https://www.sciencedaily.com/releases/2025/05/250514164320.htm Listen to the first notes of an old, beloved song. Can you name that tune? If you can, congratulations -- it's a triumph of your associative memory, in which one piece of information (the first few notes) triggers the memory of the entire pattern (the song), without you actually having to hear the rest of the song again. We use this handy neural mechanism to learn, remember, solve problems and generally navigate our reality. Wed, 14 May 2025 16:43:20 EDT https://www.sciencedaily.com/releases/2025/05/250514164320.htm